Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.80 extracted from

  • Mazzone, M.; Baldassarre, M.; Beznoussenko, G.; Giacchetti, G.; Cao, J.; Zucker, S.; Luini, A.; Buccione, R.
    Intracellular processing and activation of membrane type 1 matrix metalloprotease depends on its partitioning into lipid domains (2004), J. Cell Sci., 117, 6275-6287.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
furin activates proMT1-MMP, occurs intracellularly after exit from the Golgi apparatus and prior to its arrival at the plasma membrane Homo sapiens

Application

Application Comment Organism
additional information association of MT1-MMP with different membrane subdomains may be crucial in the control of its different activities like cell migration, invasion or MT1-MMP-dependent signaling pathways Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloned into a pcDNA3.0 expression vector Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-PDX completely abats MT1-MMP-induced gelatin degradation by A375 cells Homo sapiens
BB94 maturation of MT1-MMP normally occurs Homo sapiens
furin inhibits MT1-MMP partitioning at the plasma membrane Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane 80% of MT1-MMP is sorted to detergent-resistant membrane fractions, only 20% of MT1-MMP from detergent-soluble fraction undergoes intracellular processing to the mature form, which is the sole form responsible for extracellular matrix degredation Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
immunoprecipitation, presumably fully processed mature form Homo sapiens
63000
-
immunoprecipitation, proMT1-MMP Homo sapiens
65000
-
immunoprecipitation, post-translationally modified unprocessed form, glycopeptidase F-resistant and also present if treated with inhibitors of N- and O-glycosylation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information A375 cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
membrane type-1 matrix metalloprotease
-
Homo sapiens
MT1-MMP
-
Homo sapiens