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Literature summary for 3.4.24.80 extracted from

  • Koshikawa, N.; Mizushima, H.; Minegishi, T.; Eguchi, F.; Yotsumoto, F.; Nabeshima, K.; Miyamoto, S.; Mekada, E.; Seiki, M.
    Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells (2011), Cancer Sci., 102, 111-116.
    View publication on PubMed
Search for more literature for 3.4.24.80

Inhibitors

Inhibitors Comment Organism Structure
CRM197
-
 Homo sapiens
TIMP-2 natural inhibitor of MT1-MMP Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovarian carcinoma cell
-
 Homo sapiens
-
OVCAR-8 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparin-binding epidermal growth factor + H2O
-
 Homo sapiens heparin-binding epidermal growth factor mN3-fragment + ?
-
 ?

Synonyms

Synonyms Comment Organism
membrane-type matrix metalloproteinase-1
-
 Homo sapiens
MT1-MMP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function MT1-MMP coexpressed with heparin-binding epidermal growth factor in ovarian carcinoma cells potentiates the activity of heparin-binding epidermal growth factor to promote invasive tumor growth and spreading in vivo. MT1-MMP promotes heparin-binding epidermal growth factor-dependent proliferation of ovarian carcinoma cells Homo sapiens