Information on EC 3.2.1.18 - exo-alpha-sialidase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.2.1.18
-
RECOMMENDED NAME
GeneOntology No.
exo-alpha-sialidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Other glycan degradation
-
-
Sphingolipid metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
acetylneuraminyl hydrolase
The enzyme does not act on 4-O-acetylated sialic acids. endo-alpha-Sialidase activity is listed as EC 3.2.1.129, endo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-67-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
DSM 43798
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Arthrobacter nicotianae
Arthrobacter sialophilus
-
-
-
Manually annotated by BRENDA team
Arthrobacter ureafaciens
-
UniProt
Manually annotated by BRENDA team
starfish
-
-
Manually annotated by BRENDA team
SBT3182
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Jakari strain
-
-
Manually annotated by BRENDA team
NC08596
-
-
Manually annotated by BRENDA team
type D
-
-
Manually annotated by BRENDA team
Clostridium perfringens type A
type A
-
-
Manually annotated by BRENDA team
strain G12
-
-
Manually annotated by BRENDA team
strain G12
-
-
Manually annotated by BRENDA team
strain KCTC3075
UniProt
Manually annotated by BRENDA team
oyster
-
-
Manually annotated by BRENDA team
i.e. Erysipelothrix insidosa
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
H7N9 influenza virus
-
UniProt
Manually annotated by BRENDA team
H7N9 influenza virus A/Anhui/1/2013
-
UniProt
Manually annotated by BRENDA team
H7N9 influenza virus A/Shanghai/1/2013
-
UniProt
Manually annotated by BRENDA team
human parainfluenza virus
types 1 to 3
-
-
Manually annotated by BRENDA team
i.e. hPIV-1
-
-
Manually annotated by BRENDA team
H1N1, strain A/Brisbane/59/2007-like
-
-
Manually annotated by BRENDA team
influenza A virus A/California/05/2009/H1N1
-
-
-
Manually annotated by BRENDA team
influenza A virus A/Hong Kong/156/97/H5N1
-
-
-
Manually annotated by BRENDA team
influenza A virus A/Jinan/15/90
strain A/Jinan/15/90, type H3N2
-
-
Manually annotated by BRENDA team
influenza A virus A/N1/PR/8/34
strain A/N1/PR/8/34
-
-
Manually annotated by BRENDA team
strain A/PR/8/34, type H1N1
-
-
Manually annotated by BRENDA team
influenza A virus A/South Carolina/1/1918 H1N1
strain A/South Carolina/1/1918 H1N1
UniProt
Manually annotated by BRENDA team
influenza A virus A/tokyo/3/67
strain A/tokyo/3/67, type H2N2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
N1
-
-
Manually annotated by BRENDA team
influenza A virus newCaledonia/20/99(H1N1)
-
UniProt
Manually annotated by BRENDA team
influenza B virus B/Jiangsu/10/2003
strain B/Jiangsu/10/2003
-
-
Manually annotated by BRENDA team
influenza B virus B/Kochi/41/2011
-
-
-
Manually annotated by BRENDA team
influenza B virus B/Kochi/59/2011
-
-
-
Manually annotated by BRENDA team
influenza B virus B/Kochi/60/2011
-
-
-
Manually annotated by BRENDA team
influenza B virus B/Memphis/3/89
strain B/Memphis/3/89
-
-
Manually annotated by BRENDA team
Macrobdella sp.
-
-
-
Manually annotated by BRENDA team
strain Urabe AM9
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-
Manually annotated by BRENDA team
Mumps virus Urabe AM9
strain Urabe AM9
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-
Manually annotated by BRENDA team
Newcastle disease virus Anhinga/US(FL)/44083/93
NDV
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-
Manually annotated by BRENDA team
Newcastle disease virus Clone 30
Clone 30 strain
Uniprot
Manually annotated by BRENDA team
strain GX-04/05
UniProt
Manually annotated by BRENDA team
strain Herts/33
UniProt
Manually annotated by BRENDA team
strain JS-01/05
UniProt
Manually annotated by BRENDA team
strain JS-02/05
UniProt
Manually annotated by BRENDA team
strain JS-03/05
UniProt
Manually annotated by BRENDA team
strain JS-06/05
UniProt
Manually annotated by BRENDA team
strain JS-07/05
UniProt
Manually annotated by BRENDA team
strain JS-08/05
UniProt
Manually annotated by BRENDA team
strain JS-09/05
UniProt
Manually annotated by BRENDA team
strain JS-10/05
UniProt
Manually annotated by BRENDA team
Newcastle disease virus La Sota
strain La Sota
UniProt
Manually annotated by BRENDA team
strain Mukteswar
UniProt
Manually annotated by BRENDA team
strain V4
UniProt
Manually annotated by BRENDA team
strain ZhJ-3/97
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-
Manually annotated by BRENDA team
strain ZJ-01/00
UniProt
Manually annotated by BRENDA team
no activity in Escherichia phage K1-ind(1)
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-
-
Manually annotated by BRENDA team
medaka
UniProt
Manually annotated by BRENDA team
PIV5
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-
Manually annotated by BRENDA team
starfish
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Manually annotated by BRENDA team
Pseudomonas aeruginosa Mu 15
Mu 15
-
-
Manually annotated by BRENDA team
toad
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
K1-dep phage virion: K1-dep phages require the K1 capsule for infection
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
K6646
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Manually annotated by BRENDA team
strain 2009 H1N1
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Manually annotated by BRENDA team
strain 2009 H1N1
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
11 isozymes of trans-sialidase 1, gene TS1
UniProt
Manually annotated by BRENDA team
strain Y
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Manually annotated by BRENDA team
isolated from blood of infected camels, STIB 731-AA, IL 1392
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Manually annotated by BRENDA team
Agai strain; Agari strain
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Manually annotated by BRENDA team
Agai strain
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Manually annotated by BRENDA team
Agari strain
-
-
Manually annotated by BRENDA team
A (H3N2)
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(N-glycolylneuraminic acid)(alpha2,3)Galbeta-p-nitrophenol + H2O
(N-glycolylneuraminic acid)(alpha2,3)Gal + p-nitrophenol
show the reaction diagram
(N-glycolylneuraminic acid)(alpha2,3)Galbeta-p-nitrophenol + H2O
N-glycolylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
(N-glycolylneuraminic acid)(alpha2,6)Galbeta-p-nitrophenol + H2O
(N-glycolylneuraminic acid)(alpha2,6)Gal + p-nitrophenol
show the reaction diagram
(N-glycolylneuraminic acid)(alpha2,6)Galbeta-p-nitrophenol + H2O
N-glycolylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
(N-glycolylneuraminic acid)(alpha2,6)GalNAcbeta-p-nitrophenol + H2O
(N-glycolylneuraminic acid)(alpha2,6)GalNAc + p-nitrophenol
show the reaction diagram
(trifluoromethyl)umbelliferyl alpha-sialoside + H2O
(trifluoromethyl)umbelliferone + sialic acid
show the reaction diagram
-
-
-
-
?
(trifluoromethyl)umbelliferyl alpha-sialoside + lactose
(trifluoromethyl)umbelliferone + sialyllactose
show the reaction diagram
-
-
-
-
?
2'-(4-methyl-umbelliferyl) alpha-D-N-acetylneuraminic acid + H2O
4-methyl-umbelliferol + alpha-D-N-acetylneuraminic acid
show the reaction diagram
-
-
-
-
?
2'-(4-methylumbelliferyl) alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
show the reaction diagram
2'-(4-methylumbelliferyl) alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetylneuraminic acid
show the reaction diagram
2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetylneuraminic acid
show the reaction diagram
2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
?
show the reaction diagram
-
-
-
-
?
2-(3-methoxyphenyl)-N-acetylneuraminic acid + H2O
3-methoxyphenol + N-acetylneuraminic acid
show the reaction diagram
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
show the reaction diagram
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + alpha-D-N-acetylneuraminic acid
show the reaction diagram
-
-
-
-
?
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetyl-alpha-D-neuraminic acid
show the reaction diagram
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetylneuraminic acid
show the reaction diagram
2-(4-nitrophenyl)-alpha-D-N-acetylneuraminic acid + H2O
4-nitrophenol + alpha-D-N-acetylneuraminic acid
show the reaction diagram
2-chloro-5-(4-methoxyspiro(1,2-dioxetane-3,29-(5-chloro)tricyclo[3.3.1.13,7]decan)-4-yl-phenyl-5-acetamido-3,5-dideoxy-alpha-D-glycero-D-galacto-2-nonulopyranoside)onate + H2O
?
show the reaction diagram
2-deoxy-2,3-dehydro-N-acetylneuraminic acid + H2O
N-acetylneuraminic acid
show the reaction diagram
-
reaction deduced from crystal structures and confirmed by NMR study
-
?
2-O-(3-methoxyphenyl)neuraminic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAc
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAcol
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Gal
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]GalOBn
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galol
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,6)GlcNAc
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,6)GlcNAcOBn
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,6)GlcNAcol
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNA
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNAc
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
?
show the reaction diagram
-
-
-
-
?
3'-sialyllactose + H2O
sialic acid + ?
show the reaction diagram
-
-
-
?
3'-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
3'-sialyllactose + mucin oligosaccharide
?
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl alpha-2-oxo-3-deoxynononic acid + H2O
?
show the reaction diagram
4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
show the reaction diagram
4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetylneuraminic acid
show the reaction diagram
4-methylumbelliferyl alpha-D-N-acetylneuraminic acid + H2O
?
show the reaction diagram
4-methylumbelliferyl alpha-NeuAc + H2O
4-methylumbelliferone + alpha-neuAc
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl alpha-sialoside + H2O
?
show the reaction diagram
4-methylumbelliferyl D-N-acetylneuraminyl-alpha-(2->3)-D-galactopyranoside + H2O
4-methylumbelliferol + N-acetylneuraminate + 4-methylumbelliferyl alpha-D-galactopyranoside
show the reaction diagram
4-methylumbelliferyl-3-deoxy-D-glycero-D-galacto-2-nonulosonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
show the reaction diagram
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + alpha-D-N-acetylneuraminic acid
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
4-methylumbelliferone + N-acetylneuraminic acid
show the reaction diagram
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
sialic acid + lactose
show the reaction diagram
-
-
-
?
4-nitrophenyl alpha-D-N-acetylneuraminic acid + H2O
4-nitrophenol + N-acetylneuraminic acid
show the reaction diagram
-
-
-
?
4-nitrophenyl alpha-D-N-acetylneuraminic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-nitrophenyl alpha-sialoside + H2O
4-nitrophenol + sialic acid
show the reaction diagram
-
-
-
-
?
4-nitrophenyl alpha-sialoside + H2O
?
show the reaction diagram
4-nitrophenyl alpha-sialoside + lactose
4-nitrophenol + sialyllactose
show the reaction diagram
-
-
-
-
?
4-nitrophenyl O-(3,5-dideoxy-5-fluoro-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-(3,5-dideoxy-5-fluoro-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-(3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-(3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-(3-deoxy-5-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-(3-deoxy-5-O-methyl-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-(5-azido-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-3)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-(5-azido-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2-6)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-[5-(2-azidoacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-3)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-[5-(2-azidoacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-6)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-[5-(2-fluoroacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-3)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-[5-(2-fluoroacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-6)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-[5-(2-methoxyacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-3)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
4-nitrophenyl O-[5-(2-methoxyacetamido)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid]-(2-6)-O-beta-D-galactopyranoside + H2O
?
show the reaction diagram
5-acetylneuraminic acid-(alpha2,3)Galbeta-4-nitrophenol + H2O
N-acetylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
5-acetylneuraminic acid-(alpha2,6)Galbeta-4-nitrophenol + H2O
N-acetylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
5-azidoacetylneuraminic acid-(alpha2,3)Galbeta-4-nitrophenol + H2O
N-azidoacetylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
5-azidoacetylneuraminic acid-(alpha2,6)Galbeta-4-nitrophenol + H2O
N-azidoacetylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid + H2O
5-bromo-4-chloro-3-indole + N-acetylneuraminic acid
show the reaction diagram
5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid + H2O
?
show the reaction diagram
5-fluoroacetylneuraminic acid-(alpha2,3)Galbeta-4-nitrophenol + H2O
N-fluoroacetylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
5-fluoroacetylneuraminic acid-(alpha2,6)Galbeta-4-nitrophenol + H2O
N-fluoroacetylneuraminic acid + 4-nitrophenol + ?
show the reaction diagram
-
-
-
-
?
6'-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
alpha(2-3')-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
alpha(2-3)-linked sialic acid + H2O
?
show the reaction diagram
-
the enzyme is selective for alpha(2-3)-linked sialic acid
-
-
?
alpha(2-3)-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
alpha(2-3)sialyl-lactose + H2O
?
show the reaction diagram
-
-
-
-
?
alpha(2-3)sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
-
-
-
-
?
alpha(2-3)sialylparagloboside + H2O
?
show the reaction diagram
-
-
-
-
?
alpha(2-6')-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
the nanB encoded enzyme hydrolyzes both (2-3')- and (2-6')-sialyllactose, the latter substrate is preferred
-
-
?
alpha(2-6)-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
alpha-2-oxo-3-deoxy-D-glycero-D-galacto-nononylgalactopyranoside + H2O
?
show the reaction diagram
alpha-acid glycoprotein + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-acid glycoprotein + H2O
sialic acid + ?
show the reaction diagram
-
-
-
?
alpha-phenyl-N-acetylneuraminoside + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
alpha1-acid glycoprotein + H2O
?
show the reaction diagram
alpha2,3-sialyllactose + H2O
sialic acid + lactose
show the reaction diagram
-
-
-
-
?
apotransferrin + H2O
sialic acid + ?
show the reaction diagram
-
-
-
?
bovine brain gangliosides + H2O
sialic acid + ?
show the reaction diagram
-
-
-
-
?
bovine gland submaxillary gland mucin + H2O
?
show the reaction diagram
-
-
-
-
?
bovine submaxillary gland mucin + H2O
sialic acid + ?
show the reaction diagram
bovine submaxillary mucin + H2O
sialic acid + ?
show the reaction diagram
-
-
-
-
?
Candida albicans cells + H2O
desialylated Candida albicans cells + sialic acid
show the reaction diagram
-
-
-
-
?
casein glycomacropeptide + H2O
sialic acid + ?
show the reaction diagram
-
-
-
-
?
casein glycomacropeptide + lactose
3'-sialyllactose + ?
show the reaction diagram
-
-
-
-
?
Collocalia mucoid + H2O
sialic acid + ?
show the reaction diagram
-
substrate contains a large number of terminal sialic acids
-
-
?
colomic acid + H2O
sialic acid + lactose
show the reaction diagram
-
low activity
-
-
?
colominic acid + H2O
?
show the reaction diagram
colominic acid + H2O
sialic acid + ?
show the reaction diagram
-
-
-
-
?
colominic acid + H2O
sialic acid + lactose
show the reaction diagram
envelope glycoprotein + H2O
sialic acid + ?
show the reaction diagram
Arthrobacter ureafaciens
-
-
-
-
?
fetuin + H2O
?
show the reaction diagram
fetuin + H2O
Neu5Ac + ?
show the reaction diagram
fetuin + H2O
sialic acid + ?
show the reaction diagram
ganglioside GD1a + H2O
?
show the reaction diagram
ganglioside GD1a + H2O
ganglioside GM1 + sialic acid
show the reaction diagram
ganglioside GD1a + H2O
sialic acid + ?
show the reaction diagram
ganglioside GD1a + H2O
sialic acid + ganglioside GM1
show the reaction diagram
-
-
-
-
?
ganglioside GD1b + H2O
?
show the reaction diagram
ganglioside GD1b + H2O
sialic acid + ?
show the reaction diagram
-
-
-
-
?
ganglioside GD3 + H2O
?
show the reaction diagram
ganglioside GM1 + H2O
?
show the reaction diagram
ganglioside GM2 + H2O
?
show the reaction diagram
-
-
-
-
?
ganglioside GM2 + H2O
sialic acid + ?
show the reaction diagram
-
-
-
-
?
ganglioside GM3 + H2O
?
show the reaction diagram
ganglioside GM3 + H2O
sialic acid + ?
show the reaction diagram
ganglioside GM3(Neu5Ac) + H2O
desialylated ganglioside GM3 + sialic acid
show the reaction diagram
-
i.e. Neu5Acalpha(2-3)-Galbeta(1-4)-Glcbeta(1-1)-Cer
-
-
?
ganglioside GM3(Neu5Gc) + H2O
desialylated ganglioside GM3 + sialic acid
show the reaction diagram
-
i.e. Neu5Gcalpha(2-3)-Galbeta(1-4)-Glcbeta(1-1)-Cer
-
-
?
ganglioside GQ1 + H2O
?
show the reaction diagram
-
-
-
-
?
ganglioside GT1 + H2O
?
show the reaction diagram
-
-
-
-
?
ganglioside GT1b + H2O
?
show the reaction diagram
ganglioside GT1b + H2O
sialic acid + ?
show the reaction diagram
-
-
-
?
ganglioside IV3-alpha-Neu5Ac-nLc4Cer + H2O
desialylated ganglioside nLc4Cer + sialic acid
show the reaction diagram
-
i.e. Neu5Acalpha(2-3)-Galbeta(1-4)GcNAcbeta(1-3)-Galbeta(1-4)-Glcbeta(1-1)-Cer
-
-
?
ganglioside VI3-alpha-Neu5Ac-nLc6Cer + H2O
desialylated ganglioside nLc6Cer + sialic acid
show the reaction diagram
-
i.e. Neu5Acalpha(2-3)-Galbeta(1-4)GcNAcbeta(1-3)-Galbeta(1-4)-GlcNAcbeta(1-3)-Galbeta(1-4)-Glcbeta(1-1)-Cer
-
-
?
glucomacropeptide + H2O
?
show the reaction diagram
lactosyl-ceramide + H2O
?
show the reaction diagram
-
-
-
-
?
methyl beta-lactoside + p-nitrophenyl-5,9-diacetyl neuraminic acid
?
show the reaction diagram
-
-
-
-
?
methyl beta-lactoside + p-nitrophenyl-N-acetyl heptulosonic acid
?
show the reaction diagram
-
-
-
-
?
methyl beta-lactoside + p-nitrophenyl-N-acetyl neuraminic acid
?
show the reaction diagram
-
-
-
-
?
methyl beta-lactoside + p-nitrophenyl-N-acetyl octulosonic acid
?
show the reaction diagram
-
-
-
-
?
monosialoganglioside GM3 + H2O
?
show the reaction diagram
-
-
-
-
?
mucin + H2O
sialic acid + ?
show the reaction diagram
N-(2,4,7,8,9-penta-O-acetyl-N-acetyl-beta-D-neuraminoyl)phenylalanine methylester + H2O
?
show the reaction diagram
-
-
-
-
?
N-(4,7,8,9-tetra-O-acetyl-N-acetyl-2-O-benzyl-alpha-D-neuraminoyl)phenylalanine methylester + H2O
?
show the reaction diagram
-
-
-
-
?
N-acetylneuraminic acid-alpha-2,3-lactose + H2O
?
show the reaction diagram
-
-
-
-
-
N-acetylneuraminic acid-alpha-2,3-lactose + H2O
N-acetylneuraminic acid + lactose
show the reaction diagram
N-acetylneuraminic acid-alpha-2,6-D-galactose + H2O
N-acetylneuraminic acid + D-galactose
show the reaction diagram
-
-
-
-
?
N-acetylneuraminic acid-alpha-2,6-lactose + H2O
?
show the reaction diagram
-
-
-
-
-
N-acetylneuraminic acid-alpha-2,6-lactose + H2O
N-acetylneuraminic acid + lactose
show the reaction diagram
N-glycoloylneuraminic acid-alpha-2,3-lactose + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5(4-[(2,4-dinitrophenoxy)methyl]-1H-1,2,3-triazol-1-yl)Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-n-octyl + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5(azido)Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-n-octyl + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5,9-diAc(2-3)-alpha-lactose + H2O
?
show the reaction diagram
-
low activity
-
-
?
Neu5,9Ac2(alpha2,3)Galbeta-p-nitrophenol + H2O
Neu5,9Ac2(alpha2,3)Gal + p-nitrophenol
show the reaction diagram
Neu5,9Ac2(alpha2,6)Galbeta-p-nitrophenol + H2O
Neu5,9Ac2(alpha2,6)Gal + p-nitrophenol
show the reaction diagram
Neu5,9Ac2(alpha2,6)GalNAcbeta-p-nitrophenol + H2O
Neu5,9Ac2(alpha2,6)GalNAc + p-nitrophenol
show the reaction diagram
Neu5,9Ac2alpha2,6Galbeta-p-nitrophenol + H2O
Neu5,9Ac2alpha2,6Gal + p-nitrophenol
show the reaction diagram
-
low activity
-
-
?
Neu5Ac(2-3)-alpha-lactose + H2O
Neu5Ac + lactose
show the reaction diagram
Neu5Ac(2-6)-alpha-lactose + H2O
Neu5Ac + lactose
show the reaction diagram
Neu5Ac(alpha2,3)Galbeta-p-nitrophenol + H2O
Neu5Ac(alpha2,3)Gal + 4-nitrophenol
show the reaction diagram
Neu5Ac(alpha2,3)Galbeta-p-nitrophenol + H2O
Neu5Ac(alpha2,3)Gal + p-nitrophenol
show the reaction diagram
Neu5Ac(alpha2,3)Galbeta-p-nitrophenol + H2O
Neu5Acalpha2,3Gal + p-nitrophenol
show the reaction diagram
-
-
-
-
?
Neu5Ac(alpha2,3)lactose + H2O
Neu5Ac + lactose
show the reaction diagram
-
-
-
-
?
Neu5Ac(alpha2,6)-lactose + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac(alpha2,6)Galbeta-p-nitrophenol + H2O
Neu5Ac(alpha2,6)Gal + p-nitrophenol
show the reaction diagram
Neu5Ac(alpha2,6)GalNAcbeta-p-nitrophenol + H2O
Neu5Ac(alpha2,6)GalNAc + p-nitrophenol
show the reaction diagram
Neu5Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-(CH2)8COOCH3 + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-CH2(CH3)CH2CH2CH3 + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-CH2Ph + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-n-butyl + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-n-octyl + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-N3 + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac-alpha-(2->3)-Gal-beta-4-nitrophenol + H2O
Neu5Ac + 4-nitrophenyl beta-D-galactopyranoside
show the reaction diagram
-
-
-
-
?
Neu5Ac-alpha-(2->6)-Gal-beta-4-nitrophenol + H2O
Neu5Ac + 4-nitrophenyl beta-D-galactopyranoside
show the reaction diagram
-
-
-
-
?
Neu5Ac9(2,4-dinitrobenzoyl)N-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-n-octyl + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac9N-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-n-octyl + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Ac9N3-alpha-(2->3)-Gal-beta--(1->4)-Glc-beta-n-octyl + H2O
?
show the reaction diagram
-
-
-
-
?
Neu5Acalpha(2->)3Galbeta(1->)4GlcNAc + H2O
?
show the reaction diagram
Neu5Acalpha(2->3)9Galbeta(1->4)GlcNAc + H2O
?
show the reaction diagram
Neu5Acalpha(2->3)Galbeta-4-nitrophenyl + H2O
?
show the reaction diagram
Neu5Acalpha(2->3)LacNAcbeta-4-aminophenyl + H2O
?
show the reaction diagram
Neu5Acalpha(2->6)Galbeta4-nitrophenyl + H2O
?
show the reaction diagram
Neu5Acalpha(2->6)LacNAcbETA-4-aminophenyl + H2O
?
show the reaction diagram
Neu5Acalpha2,6Galbeta-p-nitrophenol + H2O
Neu5Acalpha2,6Galbeta + p-nitrophenol
show the reaction diagram
-
-
-
-
?
Neu5AcF-alpha-(2->3)-Gal-beta-4-nitrophenol + H2O
Neu5AcF + 4-nitrophenyl beta-D-galactopyranoside
show the reaction diagram
-
-
-
-
?
Neu5Gcalpha-(2-5)-O-glycolylNeu5Gc + H2O
2 Neu5Gcalpha
show the reaction diagram
Neu5Gcalpha-(2-8)-Neu5Ac + H2O
Neu5Gc + Neu5Ac
show the reaction diagram
Neu5Gcalpha-(2-8)-Neu5Gc + H2O
Neu5Gc + Neu5Gc
show the reaction diagram
Neu5glycolyl-alpha-(2->3)-Gal-beta-4-nitrophenol + H2O
N-glycolylneuraminic acid + 4-nitrophenyl beta-D-galactopyranoside
show the reaction diagram
-
-
-
-
?
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]-3,4-dimethylpyridinium + H2O
sialic acid + 3,4-dimethylpyridine
show the reaction diagram
-
-
-
-
?
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]-3-methylpyridinium + H2O
sialic acid + 3-methylpyridine
show the reaction diagram
-
-
-
-
?
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]-4-methylpyridinium + H2O
sialic acid + 4-methylpyridine
show the reaction diagram
-
-
-
-
?
N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]pyridinium + H2O
sialic acid + pyridine
show the reaction diagram
-
-
-
-
?
octyl-ganglioside GM3 + H2O
?
show the reaction diagram
-
-
-
-
?
octyl-lactoside + H2O
?
show the reaction diagram
-
-
-
-
?
orosomucoid + H2O
?
show the reaction diagram
orosomucoid + H2O
sialic acid + ?
show the reaction diagram
-
-
-
-
?
ovomucin + H2O
?
show the reaction diagram
-
-
-
-
?
p-nitrophenyl-5,9-diacetyl neuraminic acid + H2O
?
show the reaction diagram
-
-
-
-
?
p-nitrophenyl-N-acetyl heptulosonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
p-nitrophenyl-N-acetyl neuraminic acid + H2O
?
show the reaction diagram
-
-
-
-
?
p-nitrophenyl-N-acetyl octulosonic acid + H2O
?
show the reaction diagram
-
-
-
-
?
phenyl alpha-sialoside + H2O
?
show the reaction diagram
-
-
-
?
phenyl beta-sialoside + H2O
phenol + alpha-sialic acid
show the reaction diagram
mutant enzymes Y370G, Y370A, Y370N and Y370T catalyze the hydrolysis of phenyl beta-sialoside with an inversion of the anomeric configuration. Mutant enzyme Y370A shows 4% of the activity of Y370G, mutant enzymes Y370N and Y370T show 9% of the activity of Y370G
-
-
?
phenyl beta-sialoside + lactose
phenol + sialyllactose
show the reaction diagram
poly-alpha-2,8-lactose + H2O
?
show the reaction diagram
-
-
-
-
?
polysialic acid + H2O
?
show the reaction diagram
-
-
-
-
?
polysialic acid + H2O
sialic acid
show the reaction diagram
red blood ghost cells + H2O
?
show the reaction diagram
-
desialylation, preference for different species: in descending order mouse, rat, camel, goat, and dog
-
-
?
sialic acid tetramer with alpha-linked trifluoromethylumbelliferyl + H2O
?
show the reaction diagram
-
hydrolysis with formation of two alpha-linked trifluoromethylumbelliferyl glycoside-containing species, trifluoromethylumbelliferone and the TFMU sialoside monomer
-
-
?
sialic acid trimer with alpha-linked trifluoromethylumbelliferyl + H2O
?
show the reaction diagram
-
degraded with exclusive cleavage at the coumarin-sialoside bond
-
-
?
sialyl-alpha-(2-8)-sialic acid + H2O
sialic acid
show the reaction diagram
-
-
-
-
?
sialyl-alpha-2,3-lactose + H2O
?
show the reaction diagram
sialyl-alpha-2,6-lactose + H2O
?
show the reaction diagram
sialyloligosaccharides + H2O
?
show the reaction diagram
-
-
-
-
?
submaximally mucin + H2O
?
show the reaction diagram
transferrin + H2O
?
show the reaction diagram
transferrin + H2O
sialic acid + ?
show the reaction diagram
vesicular GM3 + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-