Literature summary for 3.2.1.18 extracted from

Bonten, E.J.; Campos, Y.; Zaitsev, V.; Nourse, A.; Waddell, B.; Lewis, W.; Taylor, G.; dAzzo, A.
Heterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization (2009), J. Biol. Chem., 284, 28430-28441.

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Activating Compound

Activating Compound	Comment	Organism	Structure
protective protein/cathepsin A	because of its association with protective protein/cathepsin A, which acts as a molecular chaperone, NEU1 is transported to the lysosomal compartment, catalytically activated, and stabilized	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 insect cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O	-	Homo sapiens	4-methylumbelliferone + N-acetylneuraminic acid	-	?

Synonyms

Synonyms	Comment	Organism
NEU1	-	Homo sapiens
neuraminidase-1	-	Homo sapiens
sialidase	-	Homo sapiens

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Release 2023.1 (January 2023)