Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.18 extracted from

  • Hinek, A.; Bodnaruk, T.D.; Bunda, S.; Wang, Y.; Liu, K.
    Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2 (2008), Am. J. Pathol., 173, 1042-1056.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.18

Application

Application Comment Organism
medicine treatment with Clostridium perfringens neuraminidase which is highly homologous to human Neu1 decreases human smooth muscle cell proliferation, even in cultures that do not deposit elastin. Pretreatment of aortic smooth muscle cells with exogenous neuraminidase abolishes their mitogenic responses to recombinant platelet-derived growth factor PDGF-BB and insulin-like growth factor IGF-2 Clostridium perfringens

Inhibitors

Inhibitors Comment Organism Structure
2,3-dehydro-2-deoxy-N-acetylneuraminic acid treatment of cultured human aortic smooth muscle cells induces significant up-regulation in smooth muscle cell proliferation in response to fetal bovine serum Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens neuraminidase causes the desialylation of both PDGF and IGF-1 receptors and diminishes the intracellular signals induced by the mitogenic ligands PDGF-BB and IGF-2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium perfringens
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta aortic smooth muscle Homo sapiens
-
smooth muscle aortic smooth muscle Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neuraminidase causes the desialylation of both PDGF and IGF-1 receptors and diminishes the intracellular signals induced by the mitogenic ligands PDGF-BB and IGF-2 Homo sapiens ?
-
 ?