Literature summary for 3.2.1.18 extracted from

Ryu, Y.B.; Kim, J.H.; Park, S.J.; Chang, J.S.; Rho, M.C.; Bae, K.H.; Park, K.H.; Lee, W.S.
Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis (2010), Bioorg. Med. Chem. Lett., 20, 971-974.

Search for more literature for 3.2.1.18

Inhibitors

Inhibitors	Comment	Organism	Structure
2'-methoxy-isoliquiritigenin	-	unidentified influenza virus
2'-methoxyisoliquiritigenin	noncompetitive inhibition	unidentified influenza virus
glyasperin C	20% inhibition at 0.2 mM	unidentified influenza virus
glyasperin D	20% inhibition at 0.2 mM	unidentified influenza virus
glycyrin	10% inhibition at 0.2 mM	unidentified influenza virus
glycyrol	strong inhibitory activity, noncompetitive inhibition	unidentified influenza virus
isoglycyrol	noncompetitive inhibition	unidentified influenza virus
isoliquiritigenin	strong inhibitory activity, noncompetitive inhibition	unidentified influenza virus
isoliquiritin	noncompetitive inhibition	unidentified influenza virus
isoliquiritin apioside	noncompetitive inhibition	unidentified influenza virus
kumatakenin	noncompetitive inhibition	unidentified influenza virus
licocoumarone	noncompetitive inhibition	unidentified influenza virus
licoflavonol	noncompetitive inhibition	unidentified influenza virus
licopyranocoumarin	10% inhibition at 0.2 mM	unidentified influenza virus
licorisoflavan A	30% inhibition at 0.2 mM	unidentified influenza virus
liquiritigenin	noncompetitive inhibition	unidentified influenza virus
liquiritin	noncompetitive inhibition	unidentified influenza virus
liquiritin apioside	noncompetitive inhibition	unidentified influenza virus
ononin	30% inhibition at 0.2 mM	unidentified influenza virus

Organism

Organism	UniProt	Comment	Textmining
unidentified influenza virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O	-	unidentified influenza virus	4-methylumbelliferone + N-acetylneuraminic acid	-	?

Synonyms

Synonyms	Comment	Organism
neuraminidase	-	unidentified influenza virus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0031	-	-	unidentified influenza virus	glycyrol
0.009	-	-	unidentified influenza virus	isoliquiritigenin
0.0129	-	-	unidentified influenza virus	isoliquiritin apioside
0.0182	-	-	unidentified influenza virus	liquiritin apioside
0.0206	-	-	unidentified influenza virus	licoflavonol
0.0243	-	-	unidentified influenza virus	2'-methoxy-isoliquiritigenin
0.0278	-	-	unidentified influenza virus	licocoumarone
0.0364	-	-	unidentified influenza virus	kumatakenin
0.0468	-	-	unidentified influenza virus	liquiritigenin
0.0823	-	-	unidentified influenza virus	liquiritin
0.0924	-	-	unidentified influenza virus	isoglycyrol
0.124	-	-	unidentified influenza virus	isoliquiritin

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Release 2023.1 (January 2023)