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Literature summary for 3.2.1.18 extracted from

  • Cheng, J.; Huang, S.; Yu, H.; Li, Y.; Lau, K.; Chen, X.
    Trans-sialidase activity of Photobacterium damsela alpha2,6-sialyltransferase and its application in the synthesis of sialosides (2010), Glycobiology, 20, 260-268.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.18

Activating Compound

Activating Compound Comment Organism Structure
CMP cytidine 5'-monophosphate is not required by the trans-sialidase activity of the enzyme but enhances the trans-sialidase activity modestly as a non-essential activator Photobacterium damselae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
53
-
 4-nitrophenyl alpha-D-N-acetylneuraminic acid
-
 Photobacterium damselae

Organism

Organism UniProt Comment Textmining
Photobacterium damselae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-N-acetylneuraminic acid + H2O
-
 Photobacterium damselae ?
-
 ?
alpha(2-6)-sialyllactose + H2O DELTA15Pd2,6ST-catalyzed trans-sialidase reactions follow a ping-pong bi-bi reaction mechanism, DELTA15Pd2,6ST preferentially cleaves alpha2,6-linked sialic acid Photobacterium damselae sialic acid + lactose
-
 ?

Synonyms

Synonyms Comment Organism
alpha2,6-sialidase
-
 Photobacterium damselae
alpha2,6-sialyltransferase
-
 Photobacterium damselae
alpha2,6-trans-sialidase
-
 Photobacterium damselae
DELTA15Pd2,6ST the enzyme has additional alpha2,6-trans-sialidase and alpha2,6-sialidase activities Photobacterium damselae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.88
-
 4-nitrophenyl alpha-D-N-acetylneuraminic acid
-
 Photobacterium damselae