Cloned (Comment) | Organism |
---|---|
isozyme NEU2, DNA and amino acid sequence determination and analysis, overexpression as soluble active enzyme in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-anhydro-3,5-dideoxy-5-glycolylamido-D-glycero-D-galactonon-2-enonic acid | - |
Homo sapiens | |
2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2-enonic acid | - |
Homo sapiens | |
2,6-anhydro-5-(2-azidoacetamido)-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid | - |
Homo sapiens | |
5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galactonon-2-enonic acid | - |
Homo sapiens | |
Ca2+ | - |
Homo sapiens | |
Co2+ | - |
Homo sapiens | |
Cu2+ | 95% inhibition at 10 mM | Homo sapiens | |
EDTA | 20% inhibition at 1 mM, 54% at 10 mM | Homo sapiens | |
Li+ | 9% inhibition at 10 mM | Homo sapiens | |
Mg2+ | - |
Homo sapiens | |
Mn2+ | 28% inhibition at 10 mM | Homo sapiens | |
additional information | design of a sialidase inhibitor selective against human NEU2, inhibitor docking using also the crystal structure of the enzyme, overview | Homo sapiens | |
zanamivir | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme NEU2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | one potential N-linked glycosylation site | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(N-glycolylneuraminic acid)(alpha2,3)Galbeta-p-nitrophenol + H2O | - |
Homo sapiens | N-glycolylneuraminic acid + 4-nitrophenol + ? | - |
? | |
(N-glycolylneuraminic acid)(alpha2,6)Galbeta-p-nitrophenol + H2O | - |
Homo sapiens | N-glycolylneuraminic acid + 4-nitrophenol + ? | - |
? | |
2'-(4-methyl-umbelliferyl) alpha-D-N-acetylneuraminic acid + H2O | - |
Homo sapiens | 4-methyl-umbelliferol + alpha-D-N-acetylneuraminic acid | - |
? | |
5-acetylneuraminic acid-(alpha2,3)Galbeta-4-nitrophenol + H2O | - |
Homo sapiens | N-acetylneuraminic acid + 4-nitrophenol + ? | - |
? | |
5-acetylneuraminic acid-(alpha2,6)Galbeta-4-nitrophenol + H2O | - |
Homo sapiens | N-acetylneuraminic acid + 4-nitrophenol + ? | - |
? | |
5-azidoacetylneuraminic acid-(alpha2,3)Galbeta-4-nitrophenol + H2O | - |
Homo sapiens | N-azidoacetylneuraminic acid + 4-nitrophenol + ? | - |
? | |
5-azidoacetylneuraminic acid-(alpha2,6)Galbeta-4-nitrophenol + H2O | - |
Homo sapiens | N-azidoacetylneuraminic acid + 4-nitrophenol + ? | - |
? | |
5-fluoroacetylneuraminic acid-(alpha2,3)Galbeta-4-nitrophenol + H2O | - |
Homo sapiens | N-fluoroacetylneuraminic acid + 4-nitrophenol + ? | - |
? | |
5-fluoroacetylneuraminic acid-(alpha2,6)Galbeta-4-nitrophenol + H2O | - |
Homo sapiens | N-fluoroacetylneuraminic acid + 4-nitrophenol + ? | - |
? | |
additional information | both alpha2-3- and alpha2-6-linked sialosides are suitable substrates for NEU2 although it cleaves alpha2-3-linked sialosides more efficiently. Twenty 4-nitrophenyl-tagged alpha(2,3)- or alpha(2,6)-linked sialyl galactosides containing different terminal sialic acid forms including common N-acetylneuraminic acid, non-human N-glycolylneuraminic acid, 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid, or their C5-derivatives are used as substrates, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NEU2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 6.5 | activity range, almost inactive at pH 4.0 and pH 7.0 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0053 | - |
pH 5.5, 37°C | Homo sapiens | zanamivir | |
0.0083 | - |
pH 5.5, 37°C | Homo sapiens | 2,6-anhydro-5-(2-azidoacetamido)-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid | |
0.018 | - |
pH 5.5, 37°C | Homo sapiens | 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galactonon-2-enonic acid | |
0.034 | - |
pH 5.5, 37°C | Homo sapiens | 2,6-anhydro-3,5-dideoxy-5-glycolylamido-D-glycero-D-galactonon-2-enonic acid | |
2.1 | - |
pH 5.5, 37°C | Homo sapiens | 2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2-enonic acid |