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Literature summary for 3.2.1.18 extracted from
- Bacterial neuraminidase increases IL-8 production in lung epithelial cells via NF-kappaB-dependent pathway (2009), Biochem. Biophys. Res. Commun., 379, 754-759.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium perfringens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Clostridium perfringens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | presence of Clostridium perfringens neuraminidase up-regulates expression of interleukin-8 mRNA and protein in lung epithelial A459 and NCI-H292 cells. Enzyme significantly up-regulates IL-8 promoter activity as well as nuclear factor-kappaB reporter activity. Inhibition of nuclear factor-kappaB signaling suppresses interleukin-8 mRNA expression induced by the neuraminidase | Clostridium perfringens | ? | - |
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Release 2023.1 (January 2023)
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