4.3.1.1: aspartate ammonia-lyase
This is an abbreviated version!
For detailed information about aspartate ammonia-lyase, go to the full flat file.
Reaction
Synonyms
ammonia-lyase, aspartate, ASPA, aspartase, aspartate ammonia lyase, aspartate ammonia-lyase, aspartate:ammonia lyase, aspB, Cj0087, fumaric aminase, L-aspartase, L-aspartate ammonia lyase, L-aspartate ammonia-lyase, maspase 1, maspase 2, maspase 3
ECTree
4.3.1.1 aspartate ammonia-lyaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 4.3.1.1 - aspartate ammonia-lyase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
diethylpyrocarbonate
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inactivation, reactivation with NH2OH, aspartate, fumarate and chloride protect
guanidine hydrochloride
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at concentrations lower than 1 M, activity is gradually decreased suggesting the existence of the native tetrameric form with denaturation intermediates such as dimeric and monomeric forms of the enzyme. At higher concentrations above 1 M, the enzyme completely lost the activity, suggesting that the enzyme structure is completely denatured
MgCl2
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inhibitor at high concentrations (above 10 mM)
aspartate beta-semialdehyde
-
i.e. aspartic beta-semialdehyde.Inactivates as an active-site directed agent
fumarate
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50% inhibition at a concentration of 0.2 to 0.6 mM, pH 6.2, 50% inhibition at a concentration of 1.1 to 2.5 mM, pH 7.5
KCl
aspartase activity is severely inhibited by potassium chloride
additional information
enzyme is upregulated by oxygen limitation
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