4.3.1.1: aspartate ammonia-lyase
This is an abbreviated version!
For detailed information about aspartate ammonia-lyase, go to the full flat file.
Reaction
Synonyms
ammonia-lyase, aspartate, ASPA, aspartase, aspartate ammonia lyase, aspartate ammonia-lyase, aspartate:ammonia lyase, aspB, Cj0087, fumaric aminase, L-aspartase, L-aspartate ammonia lyase, L-aspartate ammonia-lyase, maspase 1, maspase 2, maspase 3
ECTree
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Metals Ions
Metals Ions on EC 4.3.1.1 - aspartate ammonia-lyase
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Ca2+
Cd2+
Mg2+
Mn2+
Zn2+
additional information
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enzyme is allosterically activated by its substrate and Mg2+ ions, which are required for activity at alkaline pH
Mg2+
aspartase activity is stimulated about 2fold by inclusion of 6 mM magnesium chloride in the assay
Mg2+
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maximal activity: 1.0 mM for native enzyme, 2.2 mM for monomeric mutant enzyme maspase 1, 1.8 mM for dimeric mutant enzyme maspase 2, 1.6 mM for tetrameric mutant enzyme maspase 3
Mg2+
the enzyme does not require metal ion for its activity. It is activated in the presence of metal ions. Mg2+ is the most effective
additional information
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absolute requirement for divalent metal ion at high pH value
additional information
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absolute requirement for divalent metal ion at higher pH
additional information
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no activation by Ca2+, minimal activation by Co2+, pH-dependent activation by divalent cations at high pH values