4.3.1.1: aspartate ammonia-lyase

This is an abbreviated version!
For detailed information about aspartate ammonia-lyase, go to the full flat file.

Reaction

Synonyms

ammonia-lyase, aspartate, ASPA, aspartase, aspartate ammonia lyase, aspartate ammonia-lyase, aspartate:ammonia lyase, aspB, Cj0087, fumaric aminase, L-aspartase, L-aspartate ammonia lyase, L-aspartate ammonia-lyase, maspase 1, maspase 2, maspase 3

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.1 Ammonia-lyases

                4.3.1.1 aspartate ammonia-lyase

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Results	in table
23	Activating Compound
11980	AA Sequence
15	Application
1	CAS Registry Number
18	Cloned(Commentary)
7	Crystallization (Commentary)
1	Expression
3	General Information
7	General Stability
88	Inhibitors
20	kcat/KM [mM/s]
17	Ki Value [mM]
83	KM Value [mM]
49	Metals/Ions
40	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
135	Organism
1	Oxidation Stability
8	Pathway
42	PDB ID
58	pH Optimum
9	pH Range
5	pH Stability
59	Protein Variants
22	Purification (Commentary)
17	Reaction
13	Reaction Type
110	Reference
10	Renatured (Commentary)
11	Source Tissue
84	Specific Activity [micromol/min/mg]
13	Storage Stability
189	Substrates and Products (Substrate)
45	Subunits
56	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
8	Temperature Range [°C]
22	Temperature Stability [°C]
50	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 4.3.1.1 - aspartate ammonia-lyase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Acetic anhydride

Hafnia alvei

-

activation up to 7.5fold, allosteric

650751

acid anhydride

Escherichia coli

-

activates

6009

adenosine

Hafnia alvei

-

activation to 120-130%, allosteric

651820

alpha-methyl-DL-aspartate

2 entries

AMP

Hafnia alvei

-

allosteric activation, restores original activity of trypsin-treated enzyme

651820

D-Aspartate

Escherichia coli

-

-

649266

Dimethylsulfoxide

Escherichia coli

-

activates

6001

glycerol

Escherichia coli

-

activates

6001

GTP

Hafnia alvei

-

allosteric activation, restores original activity of trypsin-treated enzyme

651820

guanosine

Hafnia alvei

-

activation to 120-130%, allosteric

651820

L-aspartate

Escherichia coli

-

activates the fumarate-amination reaction

6021

N-hydroxysuccinimide acetate

Escherichia coli

-

activates

6009

o-phospho-D-serine

Escherichia coli

-

-

649266

Propylene glycol

Escherichia coli

-

activates

6001

subtilisin BPN'

Escherichia coli

-

activates

6009

-

Trypsin

3 entries

-

additional information

2 entries

-

alpha-methyl-DL-aspartate

Escherichia coli

-

activates

6009

alpha-methyl-DL-aspartate

Escherichia coli

-

activates wild-type enzyme, mutant C-terminal-truncated and acetylated enzyme

6021

Trypsin

Escherichia coli

-

enzyme is activated several-fold by limited treatment

6002, 6005, 6009

-

Trypsin

Escherichia coli

-

mechanism of activation

6005

-

Trypsin

Hafnia alvei

-

limited digestion at pH 7.4, 30°C, first 1.5 min

651819

-

additional information

Bacillus sp. (in: Bacteria)

-

no allosteric effects

652914

-

additional information

Propionibacterium freudenreichii subsp. shermanii

-

-

6015

-