4.1.3.27: anthranilate synthase

This is an abbreviated version!
For detailed information about anthranilate synthase, go to the full flat file.

Reaction

Synonyms

ANTA synthase, anthranilate synthase, anthranilate synthase a1, anthranilate synthase alpha 1, anthranilate synthase alpha 2, anthranilate synthase alpha2, anthranilate synthase component I, anthranilate synthase-phosphoribosyltransferase, anthranilate synthetase, AS-I, ASA, ASA1, ASA2, ASalpha, ASalphabeta, ASalphabeta-1, ASB, ASB1, CaASA1, CaASA2, chorismate lyase, Glutamine amido-transferase, Glutamine amidotransferase, HvASa2, OASA, OASA1, OASA1D, OASA2, PhnAB, PhnAB anthranilate synthase, synthase, anthranilate, synthetase, anthranilate, TrpDE, TrpE, TrpED

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.27 anthranilate synthase

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Results	in table
8	Activating Compound
42078	AA Sequence
10	Application
1	CAS Registry Number
38	Cloned(Commentary)
6	Crystallization (Commentary)
3	Expression
17	General Information
2	General Stability
2	IC50 Value
174	Inhibitors
55	Ki Value [mM]
87	KM Value [mM]
8	Localization
33	Metals/Ions
74	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
204	Organism
9	Pathway
23	PDB ID
27	pH Optimum
3	pH Range
2	pI Value
50	Protein Variants
31	Purification (Commentary)
8	Reaction
6	Reaction Type
131	Reference
27	Source Tissue
23	Specific Activity [micromol/min/mg]
7	Storage Stability
150	Substrates and Products (Substrate)
57	Subunits
78	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
26	Turnover Number [1/s]

Organism

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Organism on EC 4.1.3.27 - anthranilate synthase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Acinetobacter calcoaceticus

wild-type and 2 classes of mutants: one is defective in the chorismate-binding subunit E and is incapable of catalyzing the anthranilate synthetase reaction. The second class is defective in the G subunit but produces an active E subunit, this mutation results in a requirement for p-aminobenzoate in addition to anthranilate

33282

-

-

brenda

Ailanthus altissimus

two isoenzymes: AS-a and AS-b

33301

-

-

brenda

Arabidopsis thaliana

2 entries

Archaeoglobus fulgidus

-

664871

-

-

brenda

Aspergillus nidulans

-

33283

-

-

brenda

Avena sativa

L. cv. Shokan 1, induction with oligo-N-acetylchitooligosaccharide elicitors

654024

-

-

brenda

Azospirillum brasilense

-

677912

-

-

brenda

Azospirillum brasilense Yu62

-

677912

-

-

brenda

Bacillus subtilis

-

33283, 665348

-

-

brenda

Buchnera aphidicola

-

694016

-

-

brenda

Camptotheca acuminata

-

666679

Q5XLF2, Q5XLF3

SwissProt

brenda

Catharanthus roseus

4 entries

Chromobacterium violaceum

2 entries

Claviceps purpurea

strain Pepty 695 and strain M5/95F

33288

-

-

brenda

Claviceps sp.

2 entries

Claviceps sp. SD58

-

33288, 33290

-

-

brenda

Comamonas testosteroni

-

33283

-

-

brenda

Corynebacterium glutamicum

-

33310

-

-

brenda

Cupriavidus necator

H 16

33287

-

-

brenda

Cupriavidus necator H 16

H 16

33287

-

-

brenda

Daucus carota

-

33280, 33299

-

-

brenda

Delftia acidovorans

-

33283

-

-

brenda

Escherichia coli

4 entries

Escherichia coli W3110 / ATCC 27325

gene trpED

728069

-

-

brenda

Escherichia coli W3110 trpD9923

W3110 trpD9923

705533

-

-

brenda

Euglena gracilis

-

33289

-

-

brenda

Euglena gracilis Z

-

33289

-

-

brenda

Hordeum vulgare subsp. vulgare

-

705812

B5AAU2

UniProt

brenda

Justicia adhatoda

-

749037

-

-

brenda

Klebsiella aerogenes

-

33283

-

-

brenda

Mycobacterium tuberculosis

2 entries

Mycobacterium tuberculosis CDC 1551

-

746626

P9WFX2

UniProt

brenda

Mycobacterium tuberculosis H37Rv

-

694976

P9WFX3

UniProt

brenda

Neurospora crassa

2 entries

Nicotiana sylvestris

ASA2 expressed in Astralagus sinicus

653510

-

-

brenda

Nicotiana tabacum

4 entries

Ogataea henricii

2 entries

Oryza sativa

3 entries

Oryza sativa Nipponbare

-

728450

-

-

brenda

Populus tremula x Populus alba

hybrid, clone INRA 7171-B4

728052

-

-

brenda

Pseudomonas aeruginosa

4 entries

Pseudomonas putida

-

33281, 33283, 33286, 33294, 33300

-

-

brenda

Ruta graveolens

2 entries

Saccharolobus solfataricus

2 entries

Saccharolobus solfataricus MT4

-

677906

-

-

brenda

Saccharolobus solfataricus P2

Q06128: subunit TrpE, Q06129: subunit TrpG

653636

Q06128; Q06129

UniProt

brenda

Saccharomyces cerevisiae

-

33283

-

-

brenda

Salmonella enterica

2 entries

Salmonella enterica subsp. enterica serovar Typhimurium

4 entries

Serratia marcescens

3 entries

Serratia marcescens HY150

-

33298

-

-

brenda

Sinorhizobium meliloti

-

33311

-

-

brenda

Streptomyces sp.

-

33293

-

-

brenda

Streptomyces sp. 3022a

-

33293

-

-

brenda

Streptomyces venezuelae

-

748650

-

-

brenda

Thermococcus kodakarensis

independent expression of subunits in Escherichia coli

649565

Q9YGB3

UniProt

brenda

Thermotoga maritima

genes trpE, trpGD, and trpG

718925

-

-

brenda

Zea mays

-

33299

-

-

brenda

[Bacillus] caldotenax

-

33309

-

-

brenda

Arabidopsis thaliana

-

33302, 681616, 716102, 716359, 747400, 747427

-

-

brenda

Arabidopsis thaliana

ecotype Col-0

747430

-

-

brenda

Catharanthus roseus

-

691420

Q9AW95

UniProt

brenda

Catharanthus roseus

line ASA-1

678840

-

-

brenda

Catharanthus roseus

line ASAB-1

678840

-

-

brenda

Catharanthus roseus

monofunctional enzyme

33305

-

-

brenda

Chromobacterium violaceum

-

33283

-

-

brenda

Chromobacterium violaceum

probable anthranilate synthase ORF CV0568

692505

Q7P0J9

UniProt

brenda

Claviceps sp.

-

33288, 33290

-

-

brenda

Claviceps sp.

three-enzyme complex containing anthranilate synthetase, phosphoribosyl anthranilate isomerase and indole-3-glycerol phosphate synthetase

33290

-

-

brenda

Escherichia coli

-

33276, 33283, 33306, 653835, 747843

-

-

brenda

Escherichia coli

gene trpED

728069

-

-

brenda

Escherichia coli

strain with a mutant anthranilate synthase Pro21Gln that is insensitive to feedback inhibition by Trp

33310

-

-

brenda

Escherichia coli

W3110 trpD9923

705533

-

-

brenda

Mycobacterium tuberculosis

-

694976

P9WFX3

UniProt

brenda

Mycobacterium tuberculosis

-

746626

P9WFX2

UniProt

brenda

Neurospora crassa

-

4604, 33283

-

-

brenda

Neurospora crassa

multifunctional enzyme complex of anthranilate synthetase with phosphoribosyl anthranilate isomerase and indole-3-glycerol phosphate synthetase

33296, 33297

-

-

brenda

Nicotiana tabacum

-

682358, 704881, 728052

-

-

brenda

Nicotiana tabacum

cultivar Xanthi

682362, 747926

-

-

brenda

Nicotiana tabacum

cv. Xanthi

666592

-

-

brenda

Nicotiana tabacum

two enzyme forms, one form is resistant to feedback inhibition by 0.01 mM Trp, the other form is completely inhibited by Trp at the same concentration

33299

-

-

brenda

Ogataea henricii

-

33292

-

-

brenda

Ogataea henricii

CCY 38-10-2, the organism contains an NH4-dependent enzyme (component I) and a Gln-dependent enzyme that is composed of 2 NH4+-dependent subunits and of 2 amidotransferase subunits (I2II2)

33291

-

-

brenda

Oryza sativa

-

666305, 666639, 666682, 681139, 682292, 682452, 728450

-

-

brenda

Oryza sativa

cv. Nipponbare

666602

-

-

brenda

Oryza sativa

var. Donganbyeo, and mutant lines resistant to growth inhition by 5-methyltryptophan

666593

-

-

brenda

Pseudomonas aeruginosa

-

33283, 665348, 680487

-

-

brenda

Pseudomonas aeruginosa

anthranilate synthase phnAB, composed of glutamine amidotransferase component phnB (P09786) and anthranilate synthase component pyocyanine-specific phnA (P09785)

728263

P09785; P09786

SwissProt

brenda

Pseudomonas aeruginosa

anthranilate synthase TrpEG, composed of glutamine amidotransferase component trpG (P20576) and anthanilate synthase component trpE (P20580); PA14, genes trpG, trpE

728263

P20576; P20580

SwissProt

brenda

Pseudomonas aeruginosa

one anthranilate synthase participates in Trp synthesis and is encoded by the genes trpE and trpG, the other anthranilate synthase is encoded by the genes phnA and phnB and participates in the synthesis of pyocyanin

33312

-

-

brenda

Ruta graveolens

-

33307

-

-

brenda

Ruta graveolens

a high rutacridone producing cell line R-20 and low rutacrinone producing cell line R-15

33313

-

-

brenda

Saccharolobus solfataricus

-

677906

-

-

brenda

Saccharolobus solfataricus

Q06128: subunit TrpE, Q06129: subunit TrpG

653636

Q06128; Q06129

UniProt

brenda

Salmonella enterica

-

651722

-

-

brenda

Salmonella enterica

serovar Typhimurium strain LT2

680467

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

-

33277, 33283, 33284, 33301, 33303, 33308, 653318, 702371, 715843, 746743

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

expression in Escherichia coli

650576

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

multifunctional anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase

33279

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

multifunctional enzyme anthranilate synthase/N(5'-phosphoribosyl)anthranilate synthase (ec 4.1.3.27/ec 2.4.2.18, or ASI/ASII)

33304

-

-

brenda

Serratia marcescens

-

33278, 33279, 33283, 33295, 33298

-

-

brenda

Serratia marcescens

-

653670

P00897; P00500

SwissProt

brenda

Serratia marcescens

-

666525, 716407, 747617, 748637

-

-

brenda