Information on EC 4.1.3.27 - anthranilate synthase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
4.1.3.27
-
RECOMMENDED NAME
GeneOntology No.
anthranilate synthase
PATHWAY
KEGG Link
MetaCyc Link
2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis
-
4-hydroxy-2(1H)-quinolone biosynthesis
-
acridone alkaloid biosynthesis
-
Biosynthesis of secondary metabolites
-
Metabolic pathways
-
Phenylalanine, tyrosine and tryptophan biosynthesis
-
tryptophan biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
chorismate pyruvate-lyase (amino-accepting; anthranilate-forming)
In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase ), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)]. The native enzyme in the complex uses either glutamine or, less efficiently, NH3. The enzyme separated from the complex uses NH3 only.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
anthranilate synthase
-
-
-
-
anthranilate synthase
-
-
anthranilate synthase
B5AAU2
-
anthranilate synthase
-
-
anthranilate synthase
Q9AW95
-
anthranilate synthase
Q7P0J9
-
anthranilate synthase
-
-
anthranilate synthase
Escherichia coli W3110 trpD9923
-
-
-
anthranilate synthase
-
-
anthranilate synthase
-
-
anthranilate synthase a1
-
-
anthranilate synthase alpha 1
Q5XLF3
-
anthranilate synthase alpha 2
Q5XLF2
-
anthranilate synthase alpha2
-
-
anthranilate synthase component I
P67001
-
anthranilate synthase-phosphoribosyltransferase
-
tryptophan biosynthetic enzyme complex
anthranilate synthetase
-
-
-
-
ASA1
-
major isoform of anthranilate synthase
ASA2
-
anthranilate synthase alpha-subunit
ASA2
-
feedback-insensitive enzyme
ASalpha
-
subunit
ASalpha
-
-
ASalphabeta
-
subunit
ASalphabeta-1
Q9AW95
-
CaASA1
Q5XLF3
anthranilate synthase alpha-subunit
CaASA2
Q5XLF2
anthranilate alpha-subunit
chorismate lyase
-
-
-
-
Glutamine amido-transferase
-
-
-
-
Glutamine amidotransferase
-
-
-
-
OASA1
-
alpha-subunit of anthranilate synthase
OASA1D
-
anthranilate synthase alpha subunit
OASA1D
-
feedback-insensitive alpha-subunit OASA1D (OASA1 with point mutation N323D)
OASA1D
-
gene for anthranilate synthase alpha-subunit
OASA2
-
-
OASA2
-
alpha-subunit of anthranilate synthase
OASA2
-
anthranilate synthase alpha-subunit
PhnAB anthranilate synthase
-
-
synthase, anthranilate
-
-
-
-
synthetase, anthranilate
-
-
-
-
TrpED
Escherichia coli W3110 trpD9923
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9031-59-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
wild-type and 2 classes of mutants: one is defective in the chorismate-binding subunit E and is incapable of catalyzing the anthranilate synthetase reaction. The second class is defective in the G subunit but produces an active E subunit, this mutation results in a requirement for p-aminobenzoate in addition to anthranilate
-
-
Manually annotated by BRENDA team
two isoenzymes: AS-a and AS-b
-
-
Manually annotated by BRENDA team
L. cv. Shokan 1, induction with oligo-N-acetylchitooligosaccharide elicitors
-
-
Manually annotated by BRENDA team
Azospirillum brasilense Yu62
strain Yu62
-
-
Manually annotated by BRENDA team
line ASA-1; line ASAB-1
-
-
Manually annotated by BRENDA team
monofunctional enzyme
-
-
Manually annotated by BRENDA team
probable anthranilate synthase ORF CV0568
UniProt
Manually annotated by BRENDA team
strain Pepty 695 and strain M5/95F
-
-
Manually annotated by BRENDA team
Claviceps sp.
strain SD58
-
-
Manually annotated by BRENDA team
Claviceps sp.
strain SD58; three-enzyme complex containing anthranilate synthetase, phosphoribosyl anthranilate isomerase and indole-3-glycerol phosphate synthetase
-
-
Manually annotated by BRENDA team
Claviceps sp. SD58
strain SD58
-
-
Manually annotated by BRENDA team
Cupriavidus necator H 16
H 16
-
-
Manually annotated by BRENDA team
strain with a mutant anthranilate synthase Pro21Gln that is insensitive to feedback inhibition by Trp
-
-
Manually annotated by BRENDA team
W3110 trpD9923
-
-
Manually annotated by BRENDA team
Escherichia coli W3110 trpD9923
W3110 trpD9923
-
-
Manually annotated by BRENDA team
strain Z
-
-
Manually annotated by BRENDA team
Euglena gracilis Z
strain Z
-
-
Manually annotated by BRENDA team
Hansenula henricii
-
-
-
Manually annotated by BRENDA team
Hansenula henricii
CCY 38-10-2, the organism contains an NH4-dependent enzyme (component I) and a Gln-dependent enzyme that is composed of 2 NH4+-dependent subunits and of 2 amidotransferase subunits (I2II2)
-
-
Manually annotated by BRENDA team
multifunctional enzyme complex of anthranilate synthetase with phosphoribosyl anthranilate isomerase and indole-3-glycerol phosphate synthetase
-
-
Manually annotated by BRENDA team
ASA2 expressed in Astralagus sinicus
-
-
Manually annotated by BRENDA team
cultivar Xanthi
-
-
Manually annotated by BRENDA team
cv. Xanthi
-
-
Manually annotated by BRENDA team
two enzyme forms, one form is resistant to feedback inhibition by 0.01 mM Trp, the other form is completely inhibited by Trp at the same concentration
-
-
Manually annotated by BRENDA team
cv. Nipponbare
-
-
Manually annotated by BRENDA team
var. Donganbyeo, and mutant lines resistant to growth inhition by 5-methyltryptophan
-
-
Manually annotated by BRENDA team
one anthranilate synthase participates in Trp synthesis and is encoded by the genes trpE and trpG, the other anthranilate synthase is encoded by the genes phnA and phnB and participates in the synthesis of pyocyanin
-
-
Manually annotated by BRENDA team
a high rutacridone producing cell line R-20 and low rutacrinone producing cell line R-15
-
-
Manually annotated by BRENDA team
serovar Typhimurium strain LT2
-
-
Manually annotated by BRENDA team
multifunctional anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase
-
-
Manually annotated by BRENDA team
multifunctional enzyme anthranilate synthase/N(5'-phosphoribosyl)anthranilate synthase (ec 4.1.3.27/ec 2.4.2.18, or ASI/ASII)
-
-
Manually annotated by BRENDA team
-
P00897 and P00500
SwissProt
Manually annotated by BRENDA team
strain HY150
-
-
Manually annotated by BRENDA team
Serratia marcescens HY150
strain HY150
-
-
Manually annotated by BRENDA team
strain 3022a
-
-
Manually annotated by BRENDA team
Streptomyces sp. 3022a
strain 3022a
-
-
Manually annotated by BRENDA team
Sulfolobus solfataricus MT4
strain MT4
-
-
Manually annotated by BRENDA team
independent expression of subunits in Escherichia coli
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
chanoclavine
Claviceps sp.
-
slight activation in presence of His
elymoclavine
Claviceps sp.
-
slight activation in presence of His
indoleacrylic acid
Claviceps sp.
-
slight activation in presence of His
prephenic acid
Claviceps sp.
-
slight activation in presence of His
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.72
-
-, Q5XLF2, Q5XLF3
calculation from nucleotide sequence
8.38
-
-, Q5XLF2, Q5XLF3
calculation from nucleotide sequence
PDB
SCOP
CATH
ORGANISM
Burkholderia sp. (strain 383)
Burkholderia sp. (strain 383)
Burkholderia sp. (strain 383)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)