4.1.3.27: anthranilate synthase

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For detailed information about anthranilate synthase, go to the full flat file.

Reaction

Synonyms

ANTA synthase, anthranilate synthase, anthranilate synthase a1, anthranilate synthase alpha 1, anthranilate synthase alpha 2, anthranilate synthase alpha2, anthranilate synthase component I, anthranilate synthase-phosphoribosyltransferase, anthranilate synthetase, AS-I, ASA, ASA1, ASA2, ASalpha, ASalphabeta, ASalphabeta-1, ASB, ASB1, CaASA1, CaASA2, chorismate lyase, Glutamine amido-transferase, Glutamine amidotransferase, HvASa2, OASA, OASA1, OASA1D, OASA2, PhnAB, PhnAB anthranilate synthase, synthase, anthranilate, synthetase, anthranilate, TrpDE, TrpE, TrpED

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.27 anthranilate synthase

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Results	in table
8	Activating Compound
42078	AA Sequence
10	Application
1	CAS Registry Number
38	Cloned(Commentary)
6	Crystallization (Commentary)
3	Expression
17	General Information
2	General Stability
2	IC50 Value
174	Inhibitors
55	Ki Value [mM]
87	KM Value [mM]
8	Localization
33	Metals/Ions
74	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
204	Organism
9	Pathway
23	PDB ID
27	pH Optimum
3	pH Range
2	pI Value
50	Protein Variants
31	Purification (Commentary)
8	Reaction
6	Reaction Type
131	Reference
27	Source Tissue
23	Specific Activity [micromol/min/mg]
7	Storage Stability
150	Substrates and Products (Substrate)
57	Subunits
78	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
26	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 4.1.3.27 - anthranilate synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0063

L-Trp

Oryza sativa

-

feedback-inhibition, IC50: 0.0063 mM for wild-type enzyme, 0.0933 mM for mutant S126F, 0.0316 mM for mutant Y367A, 0.0749 mM for mutant A369L, 0.101 mM for mutant Y367A/L530D and 0.0583 mM for mutant A369L/L530D

666639

0.0063

tryptophan

Mycobacterium tuberculosis

P9WFX2

at pH 8.0 and 25°C

746626