4.1.3.27: anthranilate synthase

This is an abbreviated version!
For detailed information about anthranilate synthase, go to the full flat file.

Reaction

Synonyms

ANTA synthase, anthranilate synthase, anthranilate synthase a1, anthranilate synthase alpha 1, anthranilate synthase alpha 2, anthranilate synthase alpha2, anthranilate synthase component I, anthranilate synthase-phosphoribosyltransferase, anthranilate synthetase, AS-I, ASA, ASA1, ASA2, ASalpha, ASalphabeta, ASalphabeta-1, ASB, ASB1, CaASA1, CaASA2, chorismate lyase, Glutamine amido-transferase, Glutamine amidotransferase, HvASa2, OASA, OASA1, OASA1D, OASA2, PhnAB, PhnAB anthranilate synthase, synthase, anthranilate, synthetase, anthranilate, TrpDE, TrpE, TrpED

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.27 anthranilate synthase

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Results	in table
8	Activating Compound
42078	AA Sequence
10	Application
1	CAS Registry Number
38	Cloned(Commentary)
6	Crystallization (Commentary)
3	Expression
17	General Information
2	General Stability
2	IC50 Value
174	Inhibitors
55	Ki Value [mM]
87	KM Value [mM]
8	Localization
33	Metals/Ions
74	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
204	Organism
9	Pathway
23	PDB ID
27	pH Optimum
3	pH Range
2	pI Value
50	Protein Variants
31	Purification (Commentary)
8	Reaction
6	Reaction Type
131	Reference
27	Source Tissue
23	Specific Activity [micromol/min/mg]
7	Storage Stability
150	Substrates and Products (Substrate)
57	Subunits
78	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
26	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.1.3.27 - anthranilate synthase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

in complex with its product 4-hydroxybenzoate

Escherichia coli

-

653835

sitting drop vapor diffusion method, using 150 mM trisodium citrate pH 5.5, 0.75-1.5 M ammonium sulfate, 0.25-0.5 M lithium sulfate

Mycobacterium tuberculosis

P9WFX2

746626

in the absence of physiological ligands

Saccharolobus solfataricus

Q06128; Q06129

653636

in complex with allosteric inhibitor L-tryptophan

Salmonella enterica subsp. enterica serovar Typhimurium

-

653318

partial complex (TrpE)2(TrpG)2

Salmonella enterica subsp. enterica serovar Typhimurium

-

33304

in complex with chorismate, glutamine and glutamate and in complex with L-tryptophan

Serratia marcescens

P00897; P00500

653670