4.1.3.27: anthranilate synthase
This is an abbreviated version!
For detailed information about anthranilate synthase, go to the full flat file.
Word Map on EC 4.1.3.27
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4.1.3.27
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amidotransferase
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feedback-insensitive
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trpeg
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l-tryptophan
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p-aminobenzoate
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isochorismate
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catharanthus
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roseus
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glutamine-dependent
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5-methyltryptophan
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feedback-resistant
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chorismate-utilizing
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tryptamine
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paba
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buchnera
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prephenate
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indole-3-glycerol
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4-amino-4-deoxychorismate
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indoleglycerol
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5-phosphoribosylpyrophosphate
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aminodeoxychorismate
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biotechnology
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synthesis
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molecular biology
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medicine
- 4.1.3.27
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amidotransferase
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feedback-insensitive
-
trpeg
- l-tryptophan
- p-aminobenzoate
- isochorismate
- catharanthus
- roseus
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glutamine-dependent
- 5-methyltryptophan
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feedback-resistant
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chorismate-utilizing
- tryptamine
- paba
- buchnera
- prephenate
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indole-3-glycerol
- 4-amino-4-deoxychorismate
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indoleglycerol
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5-phosphoribosylpyrophosphate
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aminodeoxychorismate
- biotechnology
- synthesis
- molecular biology
- medicine
Reaction
Synonyms
ANTA synthase, anthranilate synthase, anthranilate synthase a1, anthranilate synthase alpha 1, anthranilate synthase alpha 2, anthranilate synthase alpha2, anthranilate synthase component I, anthranilate synthase-phosphoribosyltransferase, anthranilate synthetase, AS-I, ASA, ASA1, ASA2, ASalpha, ASalphabeta, ASalphabeta-1, ASB, ASB1, CaASA1, CaASA2, chorismate lyase, Glutamine amido-transferase, Glutamine amidotransferase, HvASa2, OASA, OASA1, OASA1D, OASA2, PhnAB, PhnAB anthranilate synthase, synthase, anthranilate, synthetase, anthranilate, TrpDE, TrpE, TrpED
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 4.1.3.27 - anthranilate synthase
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REACTION DIAGRAM
chorismate + NH4+
anthranilate + pyruvate + H2O
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feedback-insensitive enzyme
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?
chorismate + ammonia
anthranilate + pyruvate + H2O
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-
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?
anthranilate + pyruvate + L-glutamate
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feedback-insensitive enzyme
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-
?
chorismate + L-Gln
anthranilate + pyruvate + L-glutamate
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anthranilate synthase activity of mutant plants resistant to growth inhition by 5-methyltryptophan is 2.2fold to 3fold higher than that of the control. OASE2 is one of the key-regulating enzyme subunits in the tryptophan biosynthetic pathway
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?
anthranilate + pyruvate + L-glutamate
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
-
?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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-
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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one subunit of the enzyme contains a chorismate binding site and catalyzes the formation of anthranilate via 2-amino-2-deoxyisochorismate. After the first step, the intermediate remains bound to the enzyme, where it is subsequently converted to anthranilate through the elimination of pyruvate
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?
chorismate + L-glutamine
anthranilate + pyruvate + L-glutamate
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?
additional information
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rate-limiting enzyme in the biosynthesis of avenanthramides
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?
additional information
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first enzyme in the branch pathway in Trp biosynthesis
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?
additional information
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regulation of the gene by attenuation
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additional information
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synthesis of the enzyme is repressed by His, anthranilate, Trp and p-aminobenzoate
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additional information
?
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synthesis of the enzyme is repressed by His, anthranilate, Trp and p-aminobenzoate
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?