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Literature summary for 4.1.3.27 extracted from
- Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues (2010), Org. Biomol. Chem., 8, 3534-3542.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| His-tagged veresion expressed in Escherichia coli C41(DE3) | Serratia marcescens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(1-carboxy-ethyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate | - |
Serratia marcescens |  |
| 1-(1-carboxy-ethyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate | - |
Serratia marcescens | |
| 1-(2-carboxy-allyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate | - |
Serratia marcescens | |
| 1-(2-carboxy-allyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate | - |
Serratia marcescens | |
| 1-carboxymethyl -6-oxo-1,6-dihydro-pyridine-3-carboxylate | - |
Serratia marcescens | |
| 2-(1-carboxy-ethylamino)-isonicotinate | - |
Serratia marcescens | |
| 2-(carboxymethyl-amino)-isonicotinate | - |
Serratia marcescens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0037 | - |
chorismate | pH 7.0, 25°C | Serratia marcescens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Serratia marcescens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| immobilized metal ion affinity chromatography (Ni2+) | Serratia marcescens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate + L-glutamine | - |
Serratia marcescens | anthranilate + pyruvate + L-glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| anthranilate synthase | - |
Serratia marcescens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.6 | - |
chorismate | pH 7.0, 25°C | Serratia marcescens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0053 | - |
1-(1-carboxy-ethyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate | pH 7.0, 25°C | Serratia marcescens | |
| 0.041 | - |
1-(1-carboxy-ethyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate | pH 7.0, 25°C | Serratia marcescens | |
| 0.05 | - |
2-(1-carboxy-ethylamino)-isonicotinate | pH 7.0, 25°C | Serratia marcescens | |
| 0.059 | - |
1-(2-carboxy-allyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate | pH 7.0, 25°C | Serratia marcescens | |
| 0.094 | - |
2-(carboxymethyl-amino)-isonicotinate | pH 7.0, 25°C | Serratia marcescens | |
| 0.1 | - |
1-carboxymethyl -6-oxo-1,6-dihydro-pyridine-3-carboxylate | pH 7.0, 25°C | Serratia marcescens | |
| 0.12 | - |
1-(2-carboxy-allyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate | pH 7.0, 25°C | Serratia marcescens | |
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