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4.1.1.22: histidine decarboxylase

This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.22

Reaction

L-histidine
=
histamine
+
CO2

Synonyms

DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.22 histidine decarboxylase

Molecular Weight

Molecular Weight on EC 4.1.1.22 - histidine decarboxylase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
gel filtration
110000
113400
-
gel filtration
115000
-
native PAGE
12000
-
1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE
121000
gel filtration
13400
-
alpha6beta6, 6 * 28800 + 6 * 13400, SDS-PAGE
145000
-
1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE
170000
-
gel filtration
190000
-
-
208000
-
equilibrium sedimentation
210000
-
gel filtration
24000
-
1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE
24892
-
6 * 24892, alpha, + 6 * 8856, beta, calculation from amino acid sequence
25380
-
6 * 25380, alpha, + 6 * 8840, beta, synthesized as a precursor proHDC pi6 of MW 205000. A cleavage between Ser81 and Ser82 generates the alpha and beta chains, calculation from nucleotide sequence
258000
-
gel filtration
27000
-
6 * 27000, alpha, + 6 * 9000, beta, SDS-PAGE
28000
-
6 * 28000, alpha, + 6 * 8000, beta, SDS-PAGE
28800
-
alpha6beta6, 6 * 28800 + 6 * 13400, SDS-PAGE
29700
-
x * 9000 + x * 29700, the larger subunit contains a pyruvate residue
34200
pi chain of HDC
37000
-
x * 37000, uncleaved proenzyme, SDS-PAGE
42500
43000
-
4 * 43000, SDS-PAGE
50000
-
2 * 50000, SDS-PAGE
53000
53000 - 55000
active enzyme form
54000
55000
66000
-
1 * 145000, alpha, + 1 * 66000, beta, SDS-PAGE
74000
8000
-
6 * 28000, alpha, + 6 * 8000, beta, SDS-PAGE
8840
-
6 * 25380, alpha, + 6 * 8840, beta, synthesized as a precursor proHDC pi6 of MW 205000. A cleavage between Ser81 and Ser82 generates the alpha and beta chains, calculation from nucleotide sequence
8856
-
6 * 24892, alpha, + 6 * 8856, beta, calculation from amino acid sequence
95000
-
enzyme form 1, 2 and 3, gel filtration
additional information