4.1.1.22: histidine decarboxylase
This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.22
-
4.1.1.22
-
high-dose
-
mast
-
autologous
-
histaminergic
-
mucosa
-
stomach
-
gastrin
-
marrow
-
alpha-fluoromethylhistidine
-
hypothalamus
-
hematopoietic
-
enterochromaffin-like
-
cyclophosphamide
-
oxyntic
-
allergic
-
etoposide
-
biogenic
-
relapsed
-
chromogranin
-
thiotepa
-
basophil
-
decarboxylases
-
melphalan
-
cimetidine
-
tuberomammillary
-
carboplatin
-
pyrilamine
-
stem-cell
-
omeprazole
-
event-free
-
hypergastrinemia
-
h1-receptors
-
morganii
-
morganella
-
thioperamide
-
mucositis
-
carmustine
-
standard-dose
-
busulfan
-
pentagastrin
-
tourette
-
mepyramine
-
sleep-wake
-
fundic
-
mastocytoma
-
reinfusion
-
cell-deficient
-
drug development
-
medicine
-
aminergic
-
diagnostics
-
nutrition
-
chlorpheniramine
-
snell
- 4.1.1.22
-
high-dose
-
mast
-
autologous
-
histaminergic
- mucosa
- stomach
- gastrin
- marrow
- alpha-fluoromethylhistidine
- hypothalamus
-
hematopoietic
-
enterochromaffin-like
- cyclophosphamide
-
oxyntic
-
allergic
- etoposide
-
biogenic
-
relapsed
-
chromogranin
-
thiotepa
-
basophil
- decarboxylases
- melphalan
- cimetidine
-
tuberomammillary
- carboplatin
-
pyrilamine
-
stem-cell
- omeprazole
-
event-free
-
hypergastrinemia
-
h1-receptors
- morganii
- morganella
- thioperamide
- mucositis
- carmustine
-
standard-dose
-
busulfan
- pentagastrin
- tourette
-
mepyramine
-
sleep-wake
- fundic
- mastocytoma
-
reinfusion
-
cell-deficient
- drug development
- medicine
-
aminergic
- diagnostics
- nutrition
-
chlorpheniramine
-
snell
Reaction
Synonyms
DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92
ECTree
Advanced search results
Crystallization
Crystallization on EC 4.1.1.22 - histidine decarboxylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
core domain, to 1.8 A resolution. Three dimers per asymmetric unit. Molecular replacement carried out using the AroDC structure as a model
in complex with the inhibitor histidine methyl ester, to 1.8 A resolution. Cofactor pyridoxal 5'-phosphate is located in the large domain. The pyridine ring of pyridoxal 5'-phosphate is sandwiched between the methyl group of Ala275 and the imidazole ring of His194. Residue Ser354 is a key residue for substrate specificity
crystal structure of active HDC at pH 4.8 at 2.5 A resolution, crystal structure of less active HDC at pH 8.0 at 2.7 A resolution, crystals are grown at room temperatur by hanging-drop vapor diffusion, drops contain 0.004 ml HDC at 12.5 mg/ml, 0.001 ml n-dodecyl-beta-D-maltoside and 0.005 ml precipitant solution from the well containing 25% polyethylene glycol 400, 8% polyethylene glycol 400, 100 mM Tris pH 8.0, and 100 mM sodium acetate, enzyme activity is regulated by pH-induced structural changes
modeling of complex with inhibitor epigallocatechin-3-gallate. The presence of epigallocatechin-3-gallate contiguous to the active site entrance leads to the movement of several residues in the active site. Epigallocatechin-3-gallate occludes the entrance channel to the enzyme active site and establishes new interactions with residues in the active site. These residues turn outward when the active site collapses
-