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4.1.1.22: histidine decarboxylase

This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.22

Reaction

L-histidine
=
histamine
+
CO2

Synonyms

DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.22 histidine decarboxylase

Substrates Products

Substrates Products on EC 4.1.1.22 - histidine decarboxylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-methyl-DL-histidine
1-methylhistamine + CO2
show the reaction diagram
1-Methylhistidine
1-Methylhistamine
show the reaction diagram
-
very poor substrate
-
-
?
2-Thiolhistidine
1-Thiolhistamine
show the reaction diagram
-
very poor substrate
-
-
?
3,4-Dihydroxyphenylalanine
Dopamine + CO2
show the reaction diagram
no substrate for wild-type. Mutant S354G acquires the ability to decarboxylate 3,4-dihydroxyphenylalanine
-
-
?
3-Methylhistidine
2-Methylhistamine
show the reaction diagram
-
very poor substrate
-
-
?
beta-(1,2,4-Triazole-3)-Ala
?
show the reaction diagram
-
very poor substrate
-
-
?
beta-(Pyridyl-2)-Ala
?
show the reaction diagram
beta-(Thiazole-2)-Ala
?
show the reaction diagram
-
very poor substrate
-
-
?
L-His
Histamine + CO2
show the reaction diagram
L-histidin
histamine + CO2
show the reaction diagram
-
-
-
?
L-histidine
histamine + CO2
show the reaction diagram
Npi-Methylhistidine
?
show the reaction diagram
additional information
?
-