4.1.1.22: histidine decarboxylase
This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.22
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4.1.1.22
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high-dose
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mast
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autologous
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histaminergic
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mucosa
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stomach
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gastrin
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marrow
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alpha-fluoromethylhistidine
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hypothalamus
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hematopoietic
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enterochromaffin-like
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cyclophosphamide
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oxyntic
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allergic
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etoposide
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biogenic
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relapsed
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chromogranin
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thiotepa
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basophil
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decarboxylases
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melphalan
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cimetidine
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tuberomammillary
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carboplatin
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pyrilamine
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stem-cell
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omeprazole
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event-free
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hypergastrinemia
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h1-receptors
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morganii
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morganella
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thioperamide
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mucositis
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carmustine
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standard-dose
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busulfan
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pentagastrin
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tourette
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mepyramine
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sleep-wake
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fundic
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mastocytoma
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reinfusion
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cell-deficient
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drug development
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medicine
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aminergic
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diagnostics
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nutrition
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chlorpheniramine
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snell
- 4.1.1.22
-
high-dose
-
mast
-
autologous
-
histaminergic
- mucosa
- stomach
- gastrin
- marrow
- alpha-fluoromethylhistidine
- hypothalamus
-
hematopoietic
-
enterochromaffin-like
- cyclophosphamide
-
oxyntic
-
allergic
- etoposide
-
biogenic
-
relapsed
-
chromogranin
-
thiotepa
-
basophil
- decarboxylases
- melphalan
- cimetidine
-
tuberomammillary
- carboplatin
-
pyrilamine
-
stem-cell
- omeprazole
-
event-free
-
hypergastrinemia
-
h1-receptors
- morganii
- morganella
- thioperamide
- mucositis
- carmustine
-
standard-dose
-
busulfan
- pentagastrin
- tourette
-
mepyramine
-
sleep-wake
- fundic
- mastocytoma
-
reinfusion
-
cell-deficient
- drug development
- medicine
-
aminergic
- diagnostics
- nutrition
-
chlorpheniramine
-
snell
Reaction
Synonyms
DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92
ECTree
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Substrates Products
Substrates Products on EC 4.1.1.22 - histidine decarboxylase
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REACTION DIAGRAM
3,4-Dihydroxyphenylalanine
Dopamine + CO2
no substrate for wild-type. Mutant S354G acquires the ability to decarboxylate 3,4-dihydroxyphenylalanine
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L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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-
?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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-
?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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-
?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
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-
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?
L-histidine
histamine + CO2
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HDC is the key enzyme involved in histamine production
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?
L-histidine
histamine + CO2
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histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator
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L-histidine
histamine + CO2
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rate-limiting step in histamine biosynthesis, enzyme activity is increased in pre-eclampsia, a complex of disorder of pregnancy involving a systemic inflammatory response and endothelial activation within the maternal vascular system, overview
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L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
the binding site of HDC does not tolerate groups other than the imidazole side chain of histidine
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L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
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expression of hdc is also mediated by the bacterial growth phase, overview
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?
L-histidine
histamine + CO2
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expression of hdc is also mediated by the bacterial growth phase, overview
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?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
histamine-producing bacteria, such as Morganella morganii, possess histidine decarboxylase, which is responsible for histamine fish poisoning due to to the ingestion of fish containing high levels of histamine produced by the bacteria
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?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
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?
L-histidine
histamine + CO2
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HDC induction may contribute to the replenishment of the reduced pool of mast cell histamine in the anaphylactic period
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L-histidine
histamine + CO2
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HDC is the rate-limiting enzyme for histamine synthesis
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L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
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HDC is the rate-limiting enzyme for histamine synthesis
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?
L-histidine
histamine + CO2
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expression of hdc is also mediated by the bacterial growth phase, overview
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?
L-histidine
histamine + CO2
-
expression of hdc is also mediated by the bacterial growth phase, overview
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-
?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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-
?
L-histidine
histamine + CO2
-
expression of hdc is also mediated by the bacterial growth phase, overview
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-
?
L-histidine
histamine + CO2
-
expression of hdc is also mediated by the bacterial growth phase, overview
-
-
?
L-histidine
histamine + CO2
histamine-producing bacteria, such as Photobacterium damselae, possess histidine decarboxylase, which is responsible for histamine fish poisoning due to to the ingestion of fish containing high levels of histamine produced by the bacteria
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?
L-histidine
histamine + CO2
histamine-producing bacteria, such as Photobacterium damselae, possess histidine decarboxylase, which is responsible for histamine fish poisoning due to to the ingestion of fish containing high levels of histamine produced by the bacteria
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?
L-histidine
histamine + CO2
histamine-producing bacteria, such as Photobacterium phosphoreum, possess histidine decarboxylase, which is responsible for histamine fish poisoning due to to the ingestion of fish containing high levels of histamine produced by the bacteria
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?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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-
?
L-histidine
histamine + CO2
histamine-producing bacteria, such as Photobacterium phosphoreum, possess histidine decarboxylase, which is responsible for histamine fish poisoning due to to the ingestion of fish containing high levels of histamine produced by the bacteria
-
-
?
L-histidine
histamine + CO2
histamine-producing bacteria, such as Photobacterium phosphoreum, possess histidine decarboxylase, which is responsible for histamine fish poisoning due to to the ingestion of fish containing high levels of histamine produced by the bacteria
-
-
?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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-
?
L-histidine
histamine + CO2
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histamine-producing bacteria, such as Raoultella planticola, possess histidine decarboxylase, which is responsible for histamine fish poisoning due to to the ingestion of fish containing high levels of histamine produced by the bacteria
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?
L-histidine
histamine + CO2
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the enzyme has roles in inflammatory and neurological diseases, and in progression of several cancer types
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L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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L-histidine
histamine + CO2
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the enzyme is a group II pyridoxal 5-phosphate-dependent L-amino acid decarboxylase, L-aaDCII
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L-histidine
histamine + CO2
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L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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?
L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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L-histidine
histamine + CO2
structure-function relationship, molecular modeling, overview
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additional information
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enzyme immunoassay for detection of histamine production
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additional information
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enzyme immunoassay for detection of histamine production
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additional information
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mast cells are known to produce histamine through a difference mechanism than HDC induction
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additional information
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biocomputational analysis of the evolutionary specificity-determinants in decreasing order: Y279, D315, P85, M97, S77, L132, R361, Y83, D348, S112, Q150, G40, L377, R415, A82, W75, P70, R286, L285, and I430, overview
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additional information
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HDC is the key enzyme for histamine biosynthesis
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additional information
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no substrates: lysine, arginine, tyrosine, tryptophan or ornithine
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additional information
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no substrates: lysine, arginine, tyrosine, tryptophan or ornithine
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