4.1.1.22: histidine decarboxylase
This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.22
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4.1.1.22
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high-dose
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mast
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autologous
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histaminergic
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mucosa
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stomach
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gastrin
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marrow
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alpha-fluoromethylhistidine
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hypothalamus
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hematopoietic
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enterochromaffin-like
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cyclophosphamide
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oxyntic
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allergic
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etoposide
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biogenic
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relapsed
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chromogranin
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thiotepa
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basophil
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decarboxylases
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melphalan
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cimetidine
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tuberomammillary
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carboplatin
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pyrilamine
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stem-cell
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omeprazole
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event-free
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hypergastrinemia
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h1-receptors
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morganii
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morganella
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thioperamide
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mucositis
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carmustine
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standard-dose
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busulfan
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pentagastrin
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tourette
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mepyramine
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sleep-wake
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fundic
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mastocytoma
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reinfusion
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cell-deficient
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drug development
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medicine
-
aminergic
-
diagnostics
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nutrition
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chlorpheniramine
-
snell
- 4.1.1.22
-
high-dose
-
mast
-
autologous
-
histaminergic
- mucosa
- stomach
- gastrin
- marrow
- alpha-fluoromethylhistidine
- hypothalamus
-
hematopoietic
-
enterochromaffin-like
- cyclophosphamide
-
oxyntic
-
allergic
- etoposide
-
biogenic
-
relapsed
-
chromogranin
-
thiotepa
-
basophil
- decarboxylases
- melphalan
- cimetidine
-
tuberomammillary
- carboplatin
-
pyrilamine
-
stem-cell
- omeprazole
-
event-free
-
hypergastrinemia
-
h1-receptors
- morganii
- morganella
- thioperamide
- mucositis
- carmustine
-
standard-dose
-
busulfan
- pentagastrin
- tourette
-
mepyramine
-
sleep-wake
- fundic
- mastocytoma
-
reinfusion
-
cell-deficient
- drug development
- medicine
-
aminergic
- diagnostics
- nutrition
-
chlorpheniramine
-
snell
Reaction
Synonyms
DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 4.1.1.22 - histidine decarboxylase
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proteolytic modification
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enzyme undergoes processing with a major processed band of 59 kDa being observed in addition to a number of minor bands. Processing to the 59 kDa band is caspase-6 dependent
proteolytic modification
the processing to the active form of mammalian HDC relies on the proteinase activity of caspase 9 and the tandem aspartate residues Asp517-Asp518, Asp550-Asp551
proteolytic modification
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the 74000 Da precursor form is converted into the mature 53000 Da form
proteolytic modification
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post-translational cleavage by caspase-9 in a mouse mastocytoma P-815, residues D547-D551 and D517-K527 are important, overview
proteolytic modification
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post-translational cleavage by caspase-9 in a mouse mastocytoma P-815, residues D547-D551 and D517-K527 are important, overview
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proteolytic modification
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74000 Da precursor is most probably processed to a carboxy truncated form of 53000-58000 Da
proteolytic modification
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at least three isoforms with molecular masses of 74000 Da, 63000 Da and 53000 Da, the latter two forms derive from the 74000 Da form by carboxyl-terminal truncation, 63000 Da isoform is probably the active form
proteolytic modification
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post-translational processing of 74000 Da HDC is required for activity, carboxyl-terminal processing generates an active 55000 Da isoform and additional isoforms with molecular weights higher than 55000 Da
proteolytic modification
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C-terminal processing of the about 74 kDa full-length protein occurs naturally in vivo, with the production of multiple truncated isoforms. The 74 kDa full-length isoform is deficient in substrate binding, the C-terminally truncated isoforms with molecular masses between 70 kDa and 58 kDa have gradually increasing specific activities
proteolytic modification
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the protein is processed into major 63, 54 and 58/59 kDa doublet bands. Processing at the HDC SKD 501/502/503 site is likely to be caspase-dependent