4.1.1.22: histidine decarboxylase
This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.22
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4.1.1.22
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high-dose
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mast
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autologous
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histaminergic
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mucosa
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stomach
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gastrin
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marrow
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alpha-fluoromethylhistidine
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hypothalamus
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hematopoietic
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enterochromaffin-like
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cyclophosphamide
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oxyntic
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allergic
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etoposide
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biogenic
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relapsed
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chromogranin
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thiotepa
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basophil
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decarboxylases
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melphalan
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cimetidine
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tuberomammillary
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carboplatin
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pyrilamine
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stem-cell
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omeprazole
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event-free
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hypergastrinemia
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h1-receptors
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morganii
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morganella
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thioperamide
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mucositis
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carmustine
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standard-dose
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busulfan
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pentagastrin
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tourette
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mepyramine
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sleep-wake
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fundic
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mastocytoma
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reinfusion
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cell-deficient
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drug development
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medicine
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aminergic
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diagnostics
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nutrition
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chlorpheniramine
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snell
- 4.1.1.22
-
high-dose
-
mast
-
autologous
-
histaminergic
- mucosa
- stomach
- gastrin
- marrow
- alpha-fluoromethylhistidine
- hypothalamus
-
hematopoietic
-
enterochromaffin-like
- cyclophosphamide
-
oxyntic
-
allergic
- etoposide
-
biogenic
-
relapsed
-
chromogranin
-
thiotepa
-
basophil
- decarboxylases
- melphalan
- cimetidine
-
tuberomammillary
- carboplatin
-
pyrilamine
-
stem-cell
- omeprazole
-
event-free
-
hypergastrinemia
-
h1-receptors
- morganii
- morganella
- thioperamide
- mucositis
- carmustine
-
standard-dose
-
busulfan
- pentagastrin
- tourette
-
mepyramine
-
sleep-wake
- fundic
- mastocytoma
-
reinfusion
-
cell-deficient
- drug development
- medicine
-
aminergic
- diagnostics
- nutrition
-
chlorpheniramine
-
snell
Reaction
Synonyms
DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92
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Application
Application on EC 4.1.1.22 - histidine decarboxylase
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diagnostics
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HDC can be used as an immunohistochemical marker for the detection of immature neoplastic mast cells in patients with mast cell-proliferative disorders
drug development
HDC is a potential target to attenuate histamine production in certain pathological states using structure-based inhibitors, design, synthesis, and test of potentially membrane-permeable pyridoxyl-substrate conjugates as inhibitors for human HDC and modeling of an active site for hHDC, which is compatible with the experimental data, overview
medicine
nutrition
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confirmatory test for identification of Enterobacter aerogenes
medicine
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histamine-mediated signaling contributes to malaria pathogenesis, histidine decarboxylase-deficient mice are highly resistant to severe malaria and display resistance to Plasmodium berghei strains ANKA and NK65
medicine
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histidine decarboxylase-deficient mice present a numerical and functional deficit in invariant NK T cells as evidenced by a drastic decrease of IL-4 and IFN-gamma production
medicine
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loss of HDC is a marker of malignant transformation and dedifferentiation of B-cells infiltrating the skin
medicine
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suppression of histamine signaling by inhibition of HDC may be a novel target of probiotics in preventing allergic diseases
dairy products must be dedicated to a thorough risk analysis and development of strategies to contrast the presence of histaminogenic Streptococcus thermophilus strains in products from raw or mildly heat-treated milk. The HdcA enzyme in crude cell-free extracts is mostly active at acidic pH values common in dairy products. NaCl concentrations lower than 5% do not affect its activity. The enzyme is quite resistant to heat treatments resembling low pasteurization, but is inactivated at 75°C for 2 min
nutrition
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dairy products must be dedicated to a thorough risk analysis and development of strategies to contrast the presence of histaminogenic Streptococcus thermophilus strains in products from raw or mildly heat-treated milk. The HdcA enzyme in crude cell-free extracts is mostly active at acidic pH values common in dairy products. NaCl concentrations lower than 5% do not affect its activity. The enzyme is quite resistant to heat treatments resembling low pasteurization, but is inactivated at 75°C for 2 min
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