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4.1.1.22: histidine decarboxylase

This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.22

Reaction

L-histidine
=
histamine
+
CO2

Synonyms

DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.22 histidine decarboxylase

Source Tissue

Source Tissue on EC 4.1.1.22 - histidine decarboxylase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
the posterodorsal medial amygdala has high levels of histidine decarboxylase
Manually annotated by BRENDA team
-
in basophilic leukemia
Manually annotated by BRENDA team
-
HDC expression is significantly increased in carcinoma cells
Manually annotated by BRENDA team
terminal
Manually annotated by BRENDA team
-
in the acute phase of infection of mice infected with Leishmania major, detected in both strains the resistant C57BL/6 and the susceptible BALB/c. Only susceptible mice known to be unable to control parasite dissemination show induction of histidine decarboxylase in their distant periaortic lymph nodes as well. During the chronic phase of infection only the heavily parasitized organs of BALB/c mice show high expression of histidine decarboxylase gene
Manually annotated by BRENDA team
-
immature, low expression level in basophilic leukemia
Manually annotated by BRENDA team
human oxyntic mucosa contains four major types of neuroendocrine cells: ECL, ghrelin, serotonin and somatostatin cells
Manually annotated by BRENDA team
-
histidine decarboxylase is induced upon infiltration of polymorphonuclear leukocytes into mouse peritoneal cavity. Histamine is synthesized by the enzyme attached to the granule membrane of polymorphonuclear leukocytes
Manually annotated by BRENDA team
additional information