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4.1.1.22: histidine decarboxylase

This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.22

Reaction

L-histidine
=
histamine
+
CO2

Synonyms

DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.22 histidine decarboxylase

Activating Compound

Activating Compound on EC 4.1.1.22 - histidine decarboxylase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Butyrate
-
highly activating for the wild-type enzyme
C/EBPbeta
-
essential for the HDC induction
-
ethanol
gastrin
-
increase of steady-state levels of 6 HDC isoforms
HdcB
-
HdcB catalyses the maturation of pyruvoyl-dependent histidine decarboxylase by cleavage of the proenzyme which results in the formation of the pyruvoyl prosthetic group
-
lipopolysaccharide
-
excreted from Escherichia coli after oral infection, stimulates the enzyme in dental pulp and gingiva, tissue-specific effects, oveview
monosodium urate
monosodium urate crystals injected into the air pouch lead to a highly upregulated mRNA level of HDC
-
pyridoxal 5'-phosphate
pyruvate
SH-groups
-
wild type and mutant enzyme each contain two SH groups per alpha-chain
toluene 2,4-diisocyanate
additional information
-