4.1.1.22: histidine decarboxylase
This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.22
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4.1.1.22
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high-dose
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mast
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autologous
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histaminergic
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mucosa
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stomach
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gastrin
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marrow
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alpha-fluoromethylhistidine
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hypothalamus
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hematopoietic
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enterochromaffin-like
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cyclophosphamide
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oxyntic
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allergic
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etoposide
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biogenic
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relapsed
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chromogranin
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thiotepa
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basophil
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decarboxylases
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melphalan
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cimetidine
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tuberomammillary
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carboplatin
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pyrilamine
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stem-cell
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omeprazole
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event-free
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hypergastrinemia
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h1-receptors
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morganii
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morganella
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thioperamide
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mucositis
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carmustine
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standard-dose
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busulfan
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pentagastrin
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tourette
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mepyramine
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sleep-wake
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fundic
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mastocytoma
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reinfusion
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cell-deficient
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drug development
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medicine
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aminergic
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diagnostics
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nutrition
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chlorpheniramine
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snell
- 4.1.1.22
-
high-dose
-
mast
-
autologous
-
histaminergic
- mucosa
- stomach
- gastrin
- marrow
- alpha-fluoromethylhistidine
- hypothalamus
-
hematopoietic
-
enterochromaffin-like
- cyclophosphamide
-
oxyntic
-
allergic
- etoposide
-
biogenic
-
relapsed
-
chromogranin
-
thiotepa
-
basophil
- decarboxylases
- melphalan
- cimetidine
-
tuberomammillary
- carboplatin
-
pyrilamine
-
stem-cell
- omeprazole
-
event-free
-
hypergastrinemia
-
h1-receptors
- morganii
- morganella
- thioperamide
- mucositis
- carmustine
-
standard-dose
-
busulfan
- pentagastrin
- tourette
-
mepyramine
-
sleep-wake
- fundic
- mastocytoma
-
reinfusion
-
cell-deficient
- drug development
- medicine
-
aminergic
- diagnostics
- nutrition
-
chlorpheniramine
-
snell
Reaction
Synonyms
DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92
ECTree
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Activating Compound
Activating Compound on EC 4.1.1.22 - histidine decarboxylase
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HdcB
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HdcB catalyses the maturation of pyruvoyl-dependent histidine decarboxylase by cleavage of the proenzyme which results in the formation of the pyruvoyl prosthetic group
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lipopolysaccharide
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excreted from Escherichia coli after oral infection, stimulates the enzyme in dental pulp and gingiva, tissue-specific effects, oveview
monosodium urate
monosodium urate crystals injected into the air pouch lead to a highly upregulated mRNA level of HDC
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SH-groups
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wild type and mutant enzyme each contain two SH groups per alpha-chain
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does not increase hdc gene expression or activity in cells, but increases HDC activity, 122% activity at 10% ethanol
ethanol
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does not increase hdc gene expression or activity in cells, but increases HDC activity
ethanol
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does not increase hdc gene expression or activity in cells, but increases HDC activity
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activates, but does not influence the enzyme expression level
pyridoxal 5'-phosphate
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activates, but does not influence the enzyme expression level
pyridoxal 5'-phosphate
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activates, but does not influence the enzyme expression level
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pyruvoyl-group is covalently bound to the alpha-subunit and undergoes Schiff base formation with histamine
pyruvate
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contains several functionally essential pyruvate residues, covalently bound through an amide linkage to a Phe residue of the peptide chain. The free carbonyl group of these pyruvate residues undergoes Schiff base formation with His as part of the catalytic process
pyruvate
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pyruvoyl-group is covalently bound to the alpha-subunit and undergoes Schiff base formation with histamine
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toluene 2,4-diisocyanate provocation causes acute allergy-like behaviors along with significant up-regulation of HDC mRNA expression and increased HDC activity
toluene 2,4-diisocyanate
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toluene 2,4-diisocyanate provocation shows a significant up-regulation of histidine decarboxylase gene expression in rats, prolonged pre-treatment of Sho-seiryu-to significantly suppresses the mRNA level of HDC upregulated by toluene 2,4-diisocyanate
12-O-tetradecanoylphorbol-13-acetate induces the enzyme
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additional information
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12-O-tetradecanoylphorbol-13-acetate induces the enzyme
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additional information
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L-histidine induces the expression of the histidine decarboxylase gene hdc
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additional information
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tartaric acid, L-lactic acid, and sulfur dioxide have no effect on enzyme synthesis and activity
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additional information
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intraperitoneal or oral administration of aspirin, dexamethasone or indomethacin elevates histidine decarboxylase activity in the stomach
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additional information
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antigen challenge induces HDC in both mast cell-dependent and mast cell-independent ways at a postanaphylactic time in the liver, lung, spleen, and ears, enzyme activity is increased in atissue-dependent manner after sensitization of wild-type mice by ovalbumin, overview
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additional information
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L-histidine induces the expression of the histidine decarboxylase gene hdc
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additional information
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tartaric acid, L-lactic acid, and sulfur dioxide have no effect on enzyme synthesis and activity
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additional information
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L-histidine induces the expression of the histidine decarboxylase gene hdc
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additional information
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tartaric acid, L-lactic acid, and sulfur dioxide have no effect on enzyme synthesis and activity
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