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4.1.1.22: histidine decarboxylase

This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.22

Reaction

L-histidine
=
histamine
+
CO2

Synonyms

DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.22 histidine decarboxylase

Cloned

Cloned on EC 4.1.1.22 - histidine decarboxylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
2 enzyme forms: 74000 Da and 74000 Da, expression in Escherichia coli
-
cDNA encodes a protein of about 74000 Da, expression in Sf9 cells
-
cDNA encoding for residues 1-512 of HDC
-
cDNA expression in AGS-B cells
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DNA and amino acid sequence analysis and comparison, intron-exon relationships, phylogenetic analysis, overview
DNA and amino acid sequence analysis, phylogenetic tree, biocomputational analysis of the evolutionary specificity-determinants in decreasing order: Y279, D315, P85, M97, S77, L132, R361, Y83, D348, S112, Q150, G40, L377, R415, A82, W75, P70, R286, L285, and I430, overview
-
enzyme expression analysis
expressed in Escherichia coli DH5alpha cells
expressed in Escherichia coli JM109 (DE3) cells
expressed in Lactococcus lactis strain NZ9000 and Escherichia coli DH5alpha cells
-
expression in COS-7 cells
-
expression in COS-7 cells as Myc- or EGFP-tagged constructs, targeting of the endoplasmic reticulum membranes, subcellular distribution pattern, overview
-
expression in COS7 cell
expression in Escherichia coli
expression in Sf9 insect cells
-
expression of 5'-3fold FLAG-tagged and 3'-HA-tagged enzyme in 293FT and P-815 cells using a lentiviral expression system
-
expression of cDNA in COS-7 cells
-
gene hdc, cDNA is cloned from chicken hypothalamic mRNA, sequence comparisons, quantitative real-time PCR enzyme expression analysis, DNA and amino acid sequence determination and anlysis, recombinant expression, the expressed protein shows high enzymatic activity
gene hdc, DNA and amino acid sequence determination and analysis
gene hdc, located on chromosome 15q21.2, different splicing products, sequence comparisons, regulatory cis elements in the human HDC promoter (TATA, GC, CACC, Sp1 and GATA boxes): two cis-elements are located between the positions -855 and -821 with respect to the transcription start point that regulates the transcription of the HDC in human basophilic cells. Other regulatory elements are located in position -500 and between positions -532 and -497. The HDC promoter also contains a CpG island involved in epigenetic regulation of its expression during the differentiation of histamine-producing cells
gene hdc, recombinant expression of His-tagged enzyme in Escherichia coli
mutant enzymes expressed in Escherichia coli
-
quantitative expression analysis in mast cells of different maturation stage of patients with systemic mastocytosis, overview
-
quantitative PCR enzyme expression analysis