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4.1.1.22: histidine decarboxylase

This is an abbreviated version!
For detailed information about histidine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.22

Reaction

L-histidine
=
histamine
+
CO2

Synonyms

DCHS, Decarboxylase, histidine, HDC, HdcA, HisDCase, histamine-forming enzyme, L-Histidine decarboxylase, pyruvoyl-dependent decarboxylase, pyruvoyl-dependent histidine decarboxylase, TOM92

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.22 histidine decarboxylase

Localization

Localization on EC 4.1.1.22 - histidine decarboxylase

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
acrosomes of spermatids and spermatozoa
-
Manually annotated by BRENDA team
the C-terminus is probably required for sorting the enzyme to the endoplasmic reticulum (ER), after which it can be removed to render the active form of the enzyme located in ER lumen
Manually annotated by BRENDA team
-
N-terminal membrane localization of the precursor 74-kDa form of the enzyme, which has neither an amino terminal signal sequence nor a hydrophobic membrane anchor, but a large C-terminal cytosolic portion, overview
Manually annotated by BRENDA team
additional information
-
granules of elicited mouse polymorphonuclear leukocytes. Histamine is synthesized by the enzyme attached to the granule membrane of polymorphonuclear leukocytes
-
Manually annotated by BRENDA team