Literature summary for 4.1.1.22 extracted from

Snell, E.E.; Guirard, B.M.
Pyridoxal phosphate-dependent histidine decarboxylase from Morganella AM-15 (1986), Methods Enzymol., 122, 139-143.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-Hydrazino-3-(4-imidazolyl)propionic acid	-	Morganella morganii
alpha-Fluoromethylhistidine	-	Morganella morganii
alpha-Methylhistidine	-	Morganella morganii
carnosine	-	Morganella morganii
epsilon-N-Pyridoxyllysine	-	Morganella morganii
Imidazoleacetic acid	-	Morganella morganii
L-Histidine ethyl ester	-	Morganella morganii
L-histidine methyl ester	-	Morganella morganii
Urocanic acid	-	Morganella morganii

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.2	-	L-His	pH 6.5-6.7	Morganella morganii

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
170000	-	gel filtration	Morganella morganii

Organism

Organism	UniProt	Comment	Textmining
Morganella morganii	-	-	-
Morganella morganii AM-15	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Morganella morganii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Morganella morganii

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-His	-	Morganella morganii	Histamine + CO2	-	?
L-His	-	Morganella morganii AM-15	Histamine + CO2	-	?

Subunits

Subunits	Comment	Organism
tetramer	-	Morganella morganii

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Morganella morganii

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Release 2023.1 (January 2023)