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Literature summary for 4.1.1.22 extracted from
- Pyruvoyl-dependent histidine decarboxylase from Clostridium perfringens and Lactobacillus buchneri (1983), J. Biol. Chem., 258, 439-444.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| pyruvate | pyruvoyl-group is covalently bound to the alpha-subunit and undergoes Schiff base formation with histamine | Lentilactobacillus buchneri |  |
| pyruvate | pyruvoyl-group is covalently bound to the alpha-subunit and undergoes Schiff base formation with histamine | Clostridium perfringens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cyanoborohydride | NaCNBH3 | Clostridium perfringens | |
| histamine | - |
Clostridium perfringens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
L-His | - |
Clostridium perfringens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 | Clostridium perfringens | |
| K2SO4 | maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 | Clostridium perfringens | |
| KCl | maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 | Clostridium perfringens | |
| MgCl2 | maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 | Clostridium perfringens | |
| NaBr | maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 | Clostridium perfringens | |
| NaCl | maximal activity is observed only in the presence of high concentrations of various salts: KCl, NaCl, NaBr, K2SO4, CaCl2 or MgCl2 | Clostridium perfringens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 9000 | - |
6 * 27000, alpha, + 6 * 9000, beta, SDS-PAGE | Clostridium perfringens |
| 27000 | - |
6 * 27000, alpha, + 6 * 9000, beta, SDS-PAGE | Clostridium perfringens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium perfringens | - |
- |
- |
| Lentilactobacillus buchneri | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Clostridium perfringens |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Clostridium perfringens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-His | - |
Lentilactobacillus buchneri | Histamine + CO2 | - |
? | |
| L-His | - |
Clostridium perfringens | Histamine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dodecamer | 6 * 27000, alpha, + 6 * 9000, beta, SDS-PAGE | Clostridium perfringens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
- |
Clostridium perfringens |
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Release 2023.1 (January 2023)
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