3.4.22.61: caspase-8
This is an abbreviated version!
For detailed information about caspase-8, go to the full flat file.
Word Map on EC 3.4.22.61
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3.4.22.61
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caspase-9
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bcl-2
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necrosis
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extrinsic
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bid
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tnf
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trail
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apoptosis-inducing
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parp
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pro-apoptotic
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anti-apoptotic
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leukemia
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fas-associated
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trail-induced
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tunel
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fasl
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annexin
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death-inducing
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factor-related
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caspase-dependent
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c-flips
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apoptosis-related
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xiap
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fas-mediated
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flip
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receptor-mediated
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nf-kappab
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polyadp-ribose
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jurkat
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necroptosis
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anti-fas
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deoxynucleotidyl
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adp-ribose
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pan-caspase
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z-vad-fmk
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tnf-related
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deltapsim
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mitochondria-dependent
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fas-induced
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survivin
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receptor-induced
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tnf-induced
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receptor-interacting
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mlkl
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mitochondria-mediated
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ripk1
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sub-g1
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apaf-1
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executioner
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drug development
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procaspase-3
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medicine
- 3.4.22.61
- caspase-9
- bcl-2
- necrosis
-
extrinsic
- bid
- tnf
-
trail
-
apoptosis-inducing
- parp
-
pro-apoptotic
-
anti-apoptotic
- leukemia
-
fas-associated
-
trail-induced
-
tunel
- fasl
-
annexin
-
death-inducing
-
factor-related
-
caspase-dependent
- c-flips
-
apoptosis-related
- xiap
-
fas-mediated
- flip
-
receptor-mediated
- nf-kappab
-
polyadp-ribose
-
jurkat
-
necroptosis
-
anti-fas
-
deoxynucleotidyl
- adp-ribose
-
pan-caspase
- z-vad-fmk
-
tnf-related
-
deltapsim
-
mitochondria-dependent
-
fas-induced
- survivin
-
receptor-induced
-
tnf-induced
-
receptor-interacting
- mlkl
-
mitochondria-mediated
- ripk1
-
sub-g1
- apaf-1
-
executioner
- drug development
- procaspase-3
- medicine
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala) =
Synonyms
apoptotic cysteine protease, apoptotic protease Mch-5, C14.004, CAP4, Casp8, caspase 8, caspase-8, cysteine aspartic acid protease 8, cysteine aspartic acid-specific protease, cysteine protease caspase-8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLICE/MACH, ICE-like apoptotic protease 5, MACH, Mch5, More, MORT1-associated CED-3 homolog
ECTree
3.4.22.61 caspase-8Advanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.22.61 - caspase-8
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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cleaved caspase-8 is detected in apoptotic cells in the adrenal gland
the levels of caspase-3 and caspase-8 in plasma are both significantly higher than in sperm
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ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway
OCUM-2M, OCUM-1, OCUM-8, OCUM-9, NUGC3, NIGC4, MKN45, MKN74, FU97, MKN7
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caspase-8 is the most important factor that controls interferon and 5-fluorouracil-induced apoptosis in hepatoma cell lines
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casp8 is maternally expressed, and transcripts continue to be present throughout embryogenesis and into larval stages
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expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview
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expression patterns of the major caspases, CASP3, 6, 7, 8, 9, and 10, and inhibitor of apoptosis proteins, survivin, CIAP1, CIAP2, XIAP, and livin, overview
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caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility
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Casp8 is essential for beta-cell apoptosis in type 1 and type 2 diabetes models and in regulating beta-cell mass and insulin secretion under physiological conditions
caspase-8L is generated by the alternative splicing of human caspase-8
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caspase-8 is the most important factor that controls interferon and 5-fluorouracil-induced apoptosis in hepatoma cell lines
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activation of caspase-8 is essential for triggering resveratrol-induced apoptotic signalling via the involvement of the mitochondrial pathway in rheumatoid arthritis fibroblast-like synoviocytes. Resveratrol causes activation of caspase-8, which in turn results in modulation of mitochondrial apoptotic machinery to promote apoptosis of rheumatoid arthritis fibroblast-like synoviocytes
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caspase-8 expression is increased in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve, prevented by ozone
increase in caspase-8 transcript levels and activity after irradiation
increase in caspase-8 transcript levels and activity after irradiation
additional information
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caspase-8 is dispensable for B-cell development, but its loss in B cells results in attenuated antibody production upon in vivo viral infection. Important role for caspase-8 in maintaining B-cell survival following stimulation of the Toll-like receptor (TLR)2, -3, and -4
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healthy and Parkinson disease brains, caspase-8 is selectively activated in brain tissue from patients with LRRK2 Parkinson disease
the activity increases in the acute phase after hypoxia in the brain of piglets
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inhibition of caspase-8 enhances the viability of the CHO cells in both batch and fed-batch suspension cultures. Caspase-8 is possible involved in the apoptotic cell death in batch and fed-batch cultures of CHO cells
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casp8 is maternally expressed, and transcripts continue to be present throughout embryogenesis and into larval stages
caspase-8 is developmentally regulated, expression level at 9.5 days is approximately twofold higher than at 17.5 days
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caspase-8 is developmentally regulated, expression level at 9.5 days is approximately twofold higher than at 17.5 days
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stem-cell-like glioma cell, low enzyme expression levels due to hypermethylation of the CASP8 promoter, also expressed in non-stem-like glioma cell
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caspase-8 activity is similar in healthy and myocardial ischemic hearts
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caspase-8 is the most important factor that controls interferon and 5-fluorouracil-induced apoptosis in hepatoma cell lines
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caspase-8 can be involved in the control of IkappaBalpha level. In addition, the activation of caspase-8 can exert, at least in the first phase of treatment with bortezomib, a protective effect in HepG2 cells, favouring the activation of the survival factor NF-kappaB
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caspase-8 is the most important factor that controls interferon and 5-fluorouracil-induced apoptosis in hepatoma cell lines
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caspase-8 deficiency in hepatocytes facilitates infection of the liver by Listeria monocytogenes, attenuates the hepatocyte proliferation wave during the first 48 hours after partial hepatectomy and, depending on the genetic background of the mice, prompts a chronic inflammatory response to the hepatectomy, as a result of which the proliferation of hepatocytes, although initially suppressed, might later be persistently enhanced, resulting in significant hepatomegaly
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caspase-8 is the most important factor that controls interferon and 5-fluorouracil-induced apoptosis in hepatoma cell lines
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caspase-8 transcripts are detected in liver after exposure to ammonia
MCF7 A/Z breast adenocarcinoma cell defective for nuclear factor kappa-B activation
