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Literature summary for 3.4.22.61 extracted from

  • Ben Moshe, T.; Barash, H.; Kang, T.B.; Kim, J.C.; Kovalenko, A.; Gross, E.; Schuchmann, M.; Abramovitch, R.; Galun, E.; Wallach, D.
    Role of caspase-8 in hepatocyte response to infection and injury in mice (2007), Hepatology, 45, 1014-1024.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-8 participates in regulation of the cellular response to infection and injury. It does so by affecting various cellular functions, including cell death, cell proliferation, and induction of inflammation ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte caspase-8 deficiency in hepatocytes facilitates infection of the liver by Listeria monocytogenes, attenuates the hepatocyte proliferation wave during the first 48 hours after partial hepatectomy and, depending on the genetic background of the mice, prompts a chronic inflammatory response to the hepatectomy, as a result of which the proliferation of hepatocytes, although initially suppressed, might later be persistently enhanced, resulting in significant hepatomegaly Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-8 participates in regulation of the cellular response to infection and injury. It does so by affecting various cellular functions, including cell death, cell proliferation, and induction of inflammation Mus musculus ?
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