Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.22.61: caspase-8

This is an abbreviated version!
For detailed information about caspase-8, go to the full flat file.

Word Map on EC 3.4.22.61

Reaction

strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala) =

Synonyms

apoptotic cysteine protease, apoptotic protease Mch-5, C14.004, CAP4, Casp8, caspase 8, caspase-8, cysteine aspartic acid protease 8, cysteine aspartic acid-specific protease, cysteine protease caspase-8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLICE/MACH, ICE-like apoptotic protease 5, MACH, Mch5, More, MORT1-associated CED-3 homolog

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.61 caspase-8

Cloned

Cloned on EC 3.4.22.61 - caspase-8

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
CASP8, expression analysis in melanoma cells
-
determination of hypermethylation of CASP8 promoter in stem-cell-like glioma cells, whereas non-stem-cell-like glioma cells exhibit a non-methylated CASP8 promoter, expression analysis, overview
-
expressed in CV-1 cells
-
expressed in HeLa cells
-
expressed in Neuro-2A and HeLa cells
-
expression analysis of caspase-8 in absence and presence of poly(ADP-ribose) polymerase 1, PARP-1, expression, the caspase-8 expression is not influenced
-
expression analysis of caspase-8 in B-cell chronic lymphocytic leukemia compared to healthy B-cells, overview
-
expression in COS-7 cells
expression in Escherichia coli
expression in HEK293T cells
expression in Saccharomyces cerevisiae
-
expression of FK506-binding protein-caspase-8 fusion protein mutants in Escherichia coli BL21(DE3) as N-terminal His-tagged constructs using pET28b. Co-expression of caspase-8 and FLIPL in HeLa cells, the active-site cleft is restricted in caspase-8-FLIPL heterodimers
-
gene CASP8, expression analysis, analysis of promoter methylation status, hypermethylation of the CASP8 promoter in stem-cell-like glioma cells
-
gene CASP8, located at chromosome 2q33-q34, DNA and amino acid sequence determination and analysis, quantitative expression analysis in neuroblastoma cells by RT-PCR, determination of methylation status of a CpG island located between exons 2 and 3 of caspase 8 in neuroblastomas, methylation inactivates the geneoverview
-
overexpression of zebrafish Casp8 in HeLa cells
-
proMch5 lacking the two N-terminal FADD-like domains are subcloned in the bacterial expression vector pET21b in frame with an N-terminal T7 tag and a C-terminal His6tag. Bacterial expression generates a mature enzyme composed of two subunits, which are derived from the precursor by processing at Asp227, Asp233, Asp391 and Asp401
-
transient coexpression of caspase wild-type parkin in HEK-293 cells identifies caspase-1, caspase-3 and caspase-8 as efficient inducers of parkin cleavage
-