3.4.22.61: caspase-8
This is an abbreviated version!
For detailed information about caspase-8, go to the full flat file.
Word Map on EC 3.4.22.61
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3.4.22.61
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caspase-9
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bcl-2
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necrosis
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extrinsic
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bid
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tnf
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trail
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apoptosis-inducing
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parp
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pro-apoptotic
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anti-apoptotic
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leukemia
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fas-associated
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trail-induced
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tunel
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fasl
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annexin
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death-inducing
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factor-related
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caspase-dependent
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c-flips
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apoptosis-related
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xiap
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fas-mediated
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flip
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receptor-mediated
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nf-kappab
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polyadp-ribose
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jurkat
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necroptosis
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anti-fas
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deoxynucleotidyl
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adp-ribose
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pan-caspase
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z-vad-fmk
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tnf-related
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deltapsim
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mitochondria-dependent
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fas-induced
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survivin
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receptor-induced
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tnf-induced
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receptor-interacting
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mlkl
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mitochondria-mediated
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ripk1
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sub-g1
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apaf-1
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executioner
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drug development
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procaspase-3
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medicine
- 3.4.22.61
- caspase-9
- bcl-2
- necrosis
-
extrinsic
- bid
- tnf
-
trail
-
apoptosis-inducing
- parp
-
pro-apoptotic
-
anti-apoptotic
- leukemia
-
fas-associated
-
trail-induced
-
tunel
- fasl
-
annexin
-
death-inducing
-
factor-related
-
caspase-dependent
- c-flips
-
apoptosis-related
- xiap
-
fas-mediated
- flip
-
receptor-mediated
- nf-kappab
-
polyadp-ribose
-
jurkat
-
necroptosis
-
anti-fas
-
deoxynucleotidyl
- adp-ribose
-
pan-caspase
- z-vad-fmk
-
tnf-related
-
deltapsim
-
mitochondria-dependent
-
fas-induced
- survivin
-
receptor-induced
-
tnf-induced
-
receptor-interacting
- mlkl
-
mitochondria-mediated
- ripk1
-
sub-g1
- apaf-1
-
executioner
- drug development
- procaspase-3
- medicine
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala) =
Synonyms
apoptotic cysteine protease, apoptotic protease Mch-5, C14.004, CAP4, Casp8, caspase 8, caspase-8, cysteine aspartic acid protease 8, cysteine aspartic acid-specific protease, cysteine protease caspase-8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLICE/MACH, ICE-like apoptotic protease 5, MACH, Mch5, More, MORT1-associated CED-3 homolog
ECTree
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Cloned
Cloned on EC 3.4.22.61 - caspase-8
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determination of hypermethylation of CASP8 promoter in stem-cell-like glioma cells, whereas non-stem-cell-like glioma cells exhibit a non-methylated CASP8 promoter, expression analysis, overview
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expression analysis of caspase-8 in absence and presence of poly(ADP-ribose) polymerase 1, PARP-1, expression, the caspase-8 expression is not influenced
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expression analysis of caspase-8 in B-cell chronic lymphocytic leukemia compared to healthy B-cells, overview
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expression in Escherichia coli
expression of FK506-binding protein-caspase-8 fusion protein mutants in Escherichia coli BL21(DE3) as N-terminal His-tagged constructs using pET28b. Co-expression of caspase-8 and FLIPL in HeLa cells, the active-site cleft is restricted in caspase-8-FLIPL heterodimers
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gene CASP8, expression analysis, analysis of promoter methylation status, hypermethylation of the CASP8 promoter in stem-cell-like glioma cells
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gene CASP8, located at chromosome 2q33-q34, DNA and amino acid sequence determination and analysis, quantitative expression analysis in neuroblastoma cells by RT-PCR, determination of methylation status of a CpG island located between exons 2 and 3 of caspase 8 in neuroblastomas, methylation inactivates the geneoverview
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proMch5 lacking the two N-terminal FADD-like domains are subcloned in the bacterial expression vector pET21b in frame with an N-terminal T7 tag and a C-terminal His6tag. Bacterial expression generates a mature enzyme composed of two subunits, which are derived from the precursor by processing at Asp227, Asp233, Asp391 and Asp401
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transient coexpression of caspase wild-type parkin in HEK-293 cells identifies caspase-1, caspase-3 and caspase-8 as efficient inducers of parkin cleavage
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