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Literature summary for 3.4.22.61 extracted from

  • Carlucci, F.; Marinello, E.; Tommassini, V.; Pisano, B.; Rosi, F.; Tabucchi, A.
    A 57-gene expression signature in B-cell chronic lymphocytic leukemia (2009), Biomed. Pharmacother., 63, 663-671.
    View publication on PubMed
Search for more literature for 3.4.22.61

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis of caspase-8 in B-cell chronic lymphocytic leukemia compared to healthy B-cells, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information nitric oxide synthase activity in leukocytes seems to inhibit Fas-induced apoptosis preventing caspase-8 activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-8 expression is reduced in B-cell chronic lymphocytic leukemia ?
-
 ?
procaspase-3 + H2O Homo sapiens cleavage of caspases 3 and 6 by caspase-8 results in apoptosis caspase-3 + ?
-
 ?
procaspase-6 + H2O Homo sapiens cleavage of caspases 3 and 6 by caspase-8 results in apoptosis caspase-6 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification ligation of the death receptor Fas, i.e. CD95, by Fas ligand results in cleavage of procaspase 8 with the consequent generation of active caspase 8 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-8 expression is reduced in B-cell chronic lymphocytic leukemia Homo sapiens ?
-
 ?
procaspase-3 + H2O activation Homo sapiens caspase-3 + ?
-
 ?
procaspase-3 + H2O cleavage of caspases 3 and 6 by caspase-8 results in apoptosis Homo sapiens caspase-3 + ?
-
 ?
procaspase-6 + H2O activation Homo sapiens caspase-6 + ?
-
 ?
procaspase-6 + H2O cleavage of caspases 3 and 6 by caspase-8 results in apoptosis Homo sapiens caspase-6 + ?
-
 ?

Synonyms

Synonyms Comment Organism
caspase 8
-
 Homo sapiens