Literature summary for 3.4.22.61 extracted from

Chun, H.J.; Zheng, L.; Ahman, M.; Wang, J.; Speirs, C.K.; Siegel, R.M.; Dale, J.K.; Puck, J.; Davis, J.; Hall, C.G.; Skoda-Smith, S.; Atkinson, T.P.; Straus, S.E.; Lenardo, M.J.
Pleiotrophic defects in lamphocyte activation caused by caspase-8 mutations lead to human immunodeficiency (2002), Nature, 419, 395-399.

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Application

Application	Comment	Organism
medicine	caspase-8 may be a potentially useful target for a new class of antiinflammatory and immunosuppressive therapeutics	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	caspase-8 has a postnatal role in immune activation of native lymphocytes	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	caspase-8 has a postnatal role in immune activation of native lymphocytes	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)