3.4.22.61: caspase-8

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For detailed information about caspase-8, go to the full flat file.

Word Map on EC 3.4.22.61

3.4.22.61

caspase-9

bcl-2

necrosis

extrinsic

bid

tnf

trail

apoptosis-inducing

parp

pro-apoptotic

anti-apoptotic

leukemia

fas-associated

trail-induced

tunel

fasl

annexin

death-inducing

factor-related

caspase-dependent

c-flips

apoptosis-related

xiap

fas-mediated

flip

receptor-mediated

nf-kappab

polyadp-ribose

jurkat

necroptosis

anti-fas

deoxynucleotidyl

adp-ribose

pan-caspase

z-vad-fmk

tnf-related

deltapsim

mitochondria-dependent

fas-induced

survivin

receptor-induced

tnf-induced

receptor-interacting

mlkl

mitochondria-mediated

ripk1

sub-g1

apaf-1

executioner

drug development

procaspase-3

medicine

Reaction

strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala) =

Synonyms

apoptotic cysteine protease, apoptotic protease Mch-5, C14.004, CAP4, Casp8, caspase 8, caspase-8, cysteine aspartic acid protease 8, cysteine aspartic acid-specific protease, cysteine protease caspase-8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLICE/MACH, ICE-like apoptotic protease 5, MACH, Mch5, More, MORT1-associated CED-3 homolog

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.61 caspase-8

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Results	in table
57	Activating Compound
41	AA Sequence
18	Application
1	CAS Registry Number
29	Cloned(Commentary)
6	Crystallization (Commentary)
7917	Disease/ Diagnostics
40	Expression
67	General Information
1	General Stability
11	IC50 Value
123	Inhibitors
8	Ki Value [mM]
9	KM Value [mM]
31	Localization
20	Molecular Weight [Da]
111	Natural Substrates/ Products (Substrates)
394	Organism
45	PDB ID
12	pH Optimum
3	pI Value
33	Posttranslational Modification
19	Protein Variants
6	Purification (Commentary)
1	Reaction
2	Reaction Type
191	Reference
1	Renatured (Commentary)
275	Source Tissue
4	Specific Activity [micromol/min/mg]
233	Substrates and Products (Substrate)
25	Subunits
73	Synonyms
15	Temperature Optimum [°C]
5	Turnover Number [1/s]

Synonyms

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Synonyms on EC 3.4.22.61 - caspase-8

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apoptotic cysteine protease

apoptotic protease Mch-5

C14.004

CAP4

Casp8

2 entries

caspase 8

7 entries

caspase-8

4 entries

cysteine aspartic acid protease 8

Homo sapiens

698264

cysteine aspartic acid-specific protease

2 entries

cysteine protease caspase-8

Homo sapiens

698976

FADD-homologous ICE/CED-3-like protease

FADD-like ICE

FLICE

2 entries

FLICE/MACH

ICE-like apoptotic protease 5

MACH

Mch5

MORT1-associated CED-3 homolog

additional information

2 entries