3.4.22.61: caspase-8
This is an abbreviated version!
For detailed information about caspase-8, go to the full flat file.
Word Map on EC 3.4.22.61
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3.4.22.61
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caspase-9
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bcl-2
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necrosis
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extrinsic
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bid
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tnf
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trail
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apoptosis-inducing
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parp
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pro-apoptotic
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anti-apoptotic
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leukemia
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fas-associated
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trail-induced
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tunel
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fasl
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annexin
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death-inducing
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factor-related
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caspase-dependent
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c-flips
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apoptosis-related
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xiap
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fas-mediated
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flip
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receptor-mediated
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nf-kappab
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polyadp-ribose
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jurkat
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necroptosis
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anti-fas
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deoxynucleotidyl
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adp-ribose
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pan-caspase
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z-vad-fmk
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tnf-related
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deltapsim
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mitochondria-dependent
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fas-induced
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survivin
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receptor-induced
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tnf-induced
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receptor-interacting
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mlkl
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mitochondria-mediated
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ripk1
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sub-g1
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apaf-1
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executioner
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drug development
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procaspase-3
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medicine
- 3.4.22.61
- caspase-9
- bcl-2
- necrosis
-
extrinsic
- bid
- tnf
-
trail
-
apoptosis-inducing
- parp
-
pro-apoptotic
-
anti-apoptotic
- leukemia
-
fas-associated
-
trail-induced
-
tunel
- fasl
-
annexin
-
death-inducing
-
factor-related
-
caspase-dependent
- c-flips
-
apoptosis-related
- xiap
-
fas-mediated
- flip
-
receptor-mediated
- nf-kappab
-
polyadp-ribose
-
jurkat
-
necroptosis
-
anti-fas
-
deoxynucleotidyl
- adp-ribose
-
pan-caspase
- z-vad-fmk
-
tnf-related
-
deltapsim
-
mitochondria-dependent
-
fas-induced
- survivin
-
receptor-induced
-
tnf-induced
-
receptor-interacting
- mlkl
-
mitochondria-mediated
- ripk1
-
sub-g1
- apaf-1
-
executioner
- drug development
- procaspase-3
- medicine
Reaction
strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala) =
Synonyms
apoptotic cysteine protease, apoptotic protease Mch-5, C14.004, CAP4, Casp8, caspase 8, caspase-8, cysteine aspartic acid protease 8, cysteine aspartic acid-specific protease, cysteine protease caspase-8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLICE/MACH, ICE-like apoptotic protease 5, MACH, Mch5, More, MORT1-associated CED-3 homolog
ECTree
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drug development
medicine
gastric cancer might be a good target of TRAIL therapy because the majority of tumor cells have intact caspase-8 expression. The anticancer efficacy may be predicted by the degree of caspase-8 activation after TRAIL treatment
drug development
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caspase-8 ia a target for structure-based drug design approach
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caspase-8 may be a potentially useful target for a new class of antiinflammatory and immunosuppressive therapeutics
medicine
caspase-8 activation mediates p53-independent apoptosis of glioma cells
medicine
caspase-8 activity prevents type 2 cytokinine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection
medicine
caspase-8 is potentially metastasis promoting in other tumor types than neuroblastoma because it stimulates cell migration
medicine
caspase-8 mediates NF-kappa-B-dependent inflammatory responses in antiviral signaling
medicine
caspase-8 plays an important role in Pseudomonas aeruginosa Exotoxin A-induced mast cell apoptosis
medicine
clinical therapies involving caspase inhibitors may arrest apoptosis, but also have the effect of promoting autophagic cell death
medicine
HER-2 cleavage contributes to the TNF-alpha-induced apoptosis pathway
medicine
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aberrant methylation of caspase 8 apoptotic signaling gene results in acquired resistance to therapy in cervical cancer
medicine
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CASP8 is a candidate gene for multiple sclerosis risk. CASP8 polymorphisms are associated with increased risk for disease susceptibility in primary progressive multiple sclerosis patients and act as genetic modifiers of the progression of multiple sclerosis in patients with this clinical form
medicine
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caspase-8 protein expression fails to independently predict survival in parotid cancer patients
medicine
compound 6'-benzyloxy-4-bromo-2'-hydroxychalcone displays potent cytotoxic properties against human leukaemia cells U-937, HL-60, K-562, NALM-6 and MOLT-3. Application results in significant activation of caspase-8 after 24 h of treatment
medicine
infection by Trypanosoma cruzi induces caspase-8 activity and caspase-8 inhibition increases trophoblast cells infection while decreases parasite-induced cellular differentiation and apoptotic cell death, but not cellular proliferation
medicine
levels of caspase-8 and caspase-9 in sperm and plasma are significantly negatively correlated with sperm concentration, motility and A % (motility grade A). The level of caspase-8 in plasma is significantly negatively correlated with sperm concentration. Compared with the healthy fertile controls, only the oligoasxadthenoteratozoospermia group exhibited significantly increased level of caspase-8 in sperm