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Literature summary for 3.4.22.61 extracted from
- TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes (2006), Cytokine, 34, 96-105.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| tumor necrosis factor-alpha | increases activity after 24 h exposure | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Z-IETD-fluoromethyl ketone | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q9JHX4 | adult male Sprague-Dawley rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| myocyte | adult ventricular myocyte | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| FLICE + H2O | 37°C | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caspase-8 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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