Reference on EC 3.4.22.61 - caspase-8
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakajima, K.; Takahashi, A.; Yaoita, Y.
Structure, expression, and function of the Xenopus laevis caspase family
J. Biol. Chem.
275
10484-10491
2000
Xenopus laevis
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
Boldin, M.P.; Goncharov, T.M.; Goltsev, Y.V.; Wallach, D.
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
Cell
85
803-815
1996
Homo sapiens (Q14790)
Fernandes-Alnemri, T.; Armstrong, R.C.; Krebs, J.F.; Srinivasula, S.M.; Wang, L.; Bullrich, F.; Fritz, L.C.; Trapani, J.A.; Tomaselli, K.J.; Litwack, G.; Alnemri, E.S.
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
Proc. Natl. Acad. Sci. USA
93
7464-7469
1996
Homo sapiens (Q14790), Homo sapiens
Himeji, D.; Horiuchi, T.; Tsukamoto, H.; Hayashi, K.; Watanabe, T.; Harada, M.
Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade
Blood
99
4070-4078
2002
Homo sapiens (Q14790), Homo sapiens
Muzio, M.; Salvesen, G.S.; Dixit, V.M.
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
J. Biol. Chem.
272
2952-2956
1997
Homo sapiens (Q14790)
Ng, F.W.H.; Nguyen, M.; Kwan, T.; Branton, P.E.; Nicholson, D.W.; Cromlish, J.A.; Shore, G.C.
p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum
J. Cell Biol.
139
327-338
1997
Homo sapiens (Q14790), Homo sapiens
Blanchard, H.; Kodandapani, L.; Mittl, P.R.E.; Di Marco, S.; Krebs, J.F.; Wu, J.C.; Tomaselli, K.J.; Gruetter, M.G.
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis
Structure
7
1125-1133
1999
Homo sapiens (Q14790), Homo sapiens
Sakamaki, K.; Tsukumo, S.I.; Yonehara, S.
Molecular cloning and characterization of mouse caspase-8
Eur. J. Biochem.
253
399-405
1998
Mus musculus (O89110), Mus musculus, Mus musculus 129/SvJ (O89110)
Blanchard, H.; Donepudi, M.; Tschopp, M.; Kodandapani, L.; Wu, J.C.; Grutter, M.G.
Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-CHO complex
J. Mol. Biol.
302
9-16
2000
Homo sapiens (Q14790)
Humke, E.W.; Ni, J.; Dixit, V.M.
ERICE, a novel FLICE-activatable caspase
J. Biol. Chem.
273
15702-15707
1998
Homo sapiens
Li, H.; Zhu, H.; Xu, C.J.; Yuan, J.
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
Cell
94
491-501
1998
Homo sapiens
Watt, W.; Koeplinger, K.A.; Mildner, A.M.; Heinrikson, R.L.; Tomasselli, A.G.; Watenpaugh, K.D.
The atomic-resolution structure of human caspase-8, a key activator of apoptosis
Structure Fold. Des.
7
1135-1143
1999
Homo sapiens (Q14790), Homo sapiens
Xu, G.; Cirilli, M.; Huang, Y.; Rich, R.L.; Myszka, D.G.; Wu, H.
Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex
Nature
410
494-497
2001
Homo sapiens
Muzio, M.; Chinnaiyan, A.M.; Kischkel, F.C.; O`Rourke, K.; et al.
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
Cell
85
817-827
1996
Homo sapiens
Medema, J.P.; Scaffidi, C.; Kischkel, F.C.; Shevchenko, A.; Mann, M.; Krammer, P.H.; Peter, M.E.
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
EMBO J.
16
2794-2804
1997
Homo sapiens, Mus musculus
Srinivasula, S.M.; Ahmad, M.; Fernandes-Almeri, T.; Liwack, G.; Alnemri, E.S.
Molecular ordering of the Fas-apoptotic pathway: the fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteien proteases
Proc. Natl. Acad. Sci. USA
93
14486-14491
1996
Homo sapiens
Chang, D.W.; Xing, Z.; Capacio, V.L.; Peter, M.E.; Yang, X.
Inerdimer processing mechanism of procaspase-8 activation
EMBO J.
22
4132-4142
2003
Homo sapiens
Kahns, S.; Kalai, M.; Jakobsen, L.D.; Clark, B.F.; Vandenabeele, P.; Jensen, P.H.
Caspase-1 and caspase-8 cleave and inactivate cellular parkin
J. Biol. Chem.
278
23376-23380
2003
Homo sapiens
Breckenridge, D.G.; Nguyen, M.; Kuppig, S.; Reth, M.; Shore, G.C.
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum
Proc. Natl. Acad. Sci. USA
99
4331-4336
2002
Homo sapiens (Q14790)
Chun, H.J.; Zheng, L.; Ahman, M.; Wang, J.; Speirs, C.K.; Siegel, R.M.; Dale, J.K.; Puck, J.; Davis, J.; Hall, C.G.; Skoda-Smith, S.; Atkinson, T.P.; Straus, S.E.; Lenardo, M.J.
Pleiotrophic defects in lamphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
Nature
419
395-399
2002
Homo sapiens
Juo, P.; Kuo, C.J.; Yuan, J.; Blenis, J.
Essential requiremnt for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
Curr. Biol.
8
1001-1008
1998
Homo sapiens
Stennicke, H.R.; Jrgensmeier, J.M.; Shin, H.; et.al.
Pro-caspase-3 is major physiologic target of caspase-8
J. Biol. Chem.
273
27084-27099
1998
Homo sapiens
van de Craen, M.; Berx, G.; van den Brande, I.; Fiers, W.; Declercq, W.; Vandenabeele, P.
Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis
FEBS Lett.
458
167-170
1999
Mus musculus
Boatright, K.M.; Deis, C.; Denault, J.B.; Sutherlin, D.P.; Salvesen, G.S.
Activiation of caspases-8 and -10 by FLIP L
Biochem. J.
382
651-657
2004
Homo sapiens (Q14790)
Benoit, V.; Chariot, A.; Delacroix, L.; Deregowski, V.; Jacobs, N.; Merville, M.P.; Bours, V.
Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression
Cancer Res.
64
2684-2691
2004
Homo sapiens (Q14790), Homo sapiens
Afshar, G.; Jelluma, N.; Yang, X.; Basila, D.; Arvold, N.D.; Karlsson, A.; Yount, G.L.; Dansen, T.B.; Koller, E.; Haas-Kogan, D.A.
Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cells
Cancer Res.
66
4223-4232
2006
Homo sapiens (Q14790)
Helfer, B.; Boswell, B.C.; Finlay, D.; Cipres, A.; Vuori, K.; Bong Kang, T.; Wallach, D.; Dorfleutner, A.; Lahti, J.M.; Flynn, D.C.; Frisch, S.M.
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions
Cancer Res.
66
4273-4278
2006
Mus musculus (O89110)
Bidere, N.; Snow, A.L.; Sakai, K.; Zheng, L.; Lenardo, M.J.
Caspase-8 Regulation by Direct Interaction with TRAF6 in T Cell Receptor-Induced NF-kappaB Activation
Curr. Biol.
16
1666-1671
2006
Homo sapiens (Q14790)
Zhu, J.; Liu, M.; Kennedy, R.H.; Liu, S.J.
TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes
Cytokine
34
96-105
2006
Rattus norvegicus (Q9JHX4)
Su, C.L.; Huang, L.L.; Huang, L.M.; Lee, J.C.; Lin, C.N.; Won, S.J.
Caspase-8 acts as a key upstream executor of mitochondria during justicidin A-induced apoptosis in human hepatoma cells
FEBS Lett.
580
3185-3191
2006
Homo sapiens (Q14790), Homo sapiens
Jenkins, C.E.; Swiatoniowski, A.; Issekutz, A.C.; Lin, T.J.
Pseudomonas aeruginosa exotoxin A induces human mast cell apoptosis by a caspase-8 and -3-dependent mechanism
J. Biol. Chem.
279
37201-37207
2004
Homo sapiens (Q14790), Homo sapiens
Liedtke, C.; Groeger, N.; Manns, M.P.; Trautwein, C.
Interferon-alpha enhances TRAIL-mediated apoptosis by up-regulating caspase-8 transcription in human hepatoma cells
J. Hepatol.
44
342-349
2006
Homo sapiens (Q14790), Homo sapiens
Dohrman, A.; Kataoka, T.; Cuenin, S.; Russell, J.Q.; Tschopp, J.; Budd, R.C.
Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation
J. Immunol.
174
5270-5278
2005
Mus musculus (O89110)
Silva, E.M.; Guillermo, L.V.; Ribeiro-Gomes, F.L.; De Meis, J.; Pereira, R.M.; Wu, Z.; Calegari-Silva, T.C.; Seabra, S.H.; Lopes, U.G.; Siegel, R.M.; Dosreis, G.A.; Lopes, M.F.
Caspase-8 activity prevents type 2 cytokine responses and is required for protective T cell-mediated immunity against Trypanosoma cruzi infection
J. Immunol.
174
6314-6321
2005
Mus musculus (O89110), Mus musculus
Beisner, D.R.; Chen, I.L.; Kolla, R.V.; Hoffmann, A.; Hedrick, S.M.
Cutting edge: innate immunity conferred by B cells is regulated by caspase-8
J. Immunol.
175
3469-3473
2005
Mus musculus (O89110)
Takahashi, K.; Kawai, T.; Kumar, H.; Sato, S.; Yonehara, S.; Akira, S.
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
J. Immunol.
176
4520-4524
2006
Homo sapiens (Q14790), Homo sapiens
Zhu, J.; Xiong, L.; Yu, B.; Wu, J.
Apoptosis induced by a new member of saponin family is mediated through caspase-8-dependent cleavage of Bcl-2
Mol. Pharmacol.
68
1831-1838
2005
Cricetulus griseus
Fischer, U.; Stroh, C.; Schulze-Osthoff, K.
Unique and overlapping substrate specificities of caspase-8 and caspase-10
Oncogene
25
152-159
2006
Homo sapiens (Q14790)
Kanehara, I.; Nakata, B.; Hirakawa, K.
Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells
Oncol. Rep.
14
1249-1253
2005
Homo sapiens (Q14790)
Yu, L.; Alva, A.; Su, H.; Dutt, P.; Freundt, E.; Welsh, S.; Baehrecke, E.H.; Lenardo, M.J.
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
Science
304
1500-1502
2004
Mus musculus (O89110)
Papandile, A.; Tyas, D.; OMalley, D.M.; Warner, C.M.
Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes
Zygote
12
57-64
2004
Mus musculus (O89110), Mus musculus
Senft, J.; Helfer, B.; Frisch, S.M.
Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility
Cancer Res.
67
11505-11509
2007
Homo sapiens
Liadis, N.; Salmena, L.; Kwan, E.; Tajmir, P.; Schroer, S.A.; Radziszewska, A.; Li, X.; Sheu, L.; Eweida, M.; Xu, S.; Gaisano, H.Y.; Hakem, R.; Woo, M.
Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models
Diabetes
56
2302-2311
2007
Mus musculus
Qi, W.; Wu, H.; Yang, L.; Boyd, D.D.; Wang, Z.
A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression
EMBO J.
26
65-75
2007
Homo sapiens
Sakata, S.; Yan, Y.; Satou, Y.; Momoi, A.; Ngo-Hazelett, P.; Nozaki, M.; Furutani-Seiki, M.; Postlethwait, J.H.; Yonehara, S.; Sakamaki, K.
Conserved function of caspase-8 in apoptosis during bony fish evolution
Gene
396
134-148
2007
Danio rerio
Ben Moshe, T.; Barash, H.; Kang, T.B.; Kim, J.C.; Kovalenko, A.; Gross, E.; Schuchmann, M.; Abramovitch, R.; Galun, E.; Wallach, D.
Role of caspase-8 in hepatocyte response to infection and injury in mice
Hepatology
45
1014-1024
2007
Mus musculus
Bae, S.; Ha, T.S.; Yoon, Y.; Lee, J.; Cha, H.J.; Yoo, H.; Choe, T.B.; Li, S.; Sohn, I.; Kim, J.Y.; Kim, C.S.; Jin, H.O.; Lee, H.C.; Park, I.C.; Kim, C.S.; Jin, Y.W.; Ahn, S.K.
Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro
Int. J. Mol. Med.
21
381-386
2008
Mus musculus
Koike, K.; Takaki, A.; Tatsukawa, M.; Suzuki, M.; Shiraha, H.; Iwasaki, Y.; Sakaguchi, K.; Shiratori, Y.
Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines
Int. J. Oncol.
29
1253-1261
2006
Homo sapiens
Lemmers, B.; Salmena, L.; Bidere, N.; Su, H.; Matysiak-Zablocki, E.; Murakami, K.; Ohashi, P.S.; Jurisicova, A.; Lenardo, M.; Hakem, R.; Hakem, A.
Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling
J. Biol. Chem.
282
7416-7423
2007
Mus musculus
Barbero, S.; Barila, D.; Mielgo, A.; Stagni, V.; Clair, K.; Stupack, D.
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration
J. Biol. Chem.
283
13031-13034
2008
Homo sapiens
Reinehr, R.; Sommerfeld, A.; Keitel, V.; Grether-Beck, S.; Hauessinger, D.
Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes
J. Biol. Chem.
283
2211-2222
2008
Rattus norvegicus
Lehnardt, S.; Wennekamp, J.; Freyer, D.; Liedtke, C.; Krueger, C.; Nitsch, R.; Bechmann, I.; Weber, J.R.; Henneke, P.
TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia
J. Immunol.
179
6134-6143
2007
Mus musculus
Yun, C.Y.; Liu, S.; Lim, S.F.; Wang, T.; Chung, B.Y.; Jiat Teo, J.; Chuan, K.H.; Soon, A.S.; Goh, K.S.; Song, Z.
Specific inhibition of caspase-8 and -9 in CHO cells enhances cell viability in batch and fed-batch cultures
Metab. Eng.
9
406-418
2007
Cricetulus griseus
Calvaruso, G.; Giuliano, M.; Portanova, P.; De Blasio, A.; Vento, R.; Tesoriere, G.
Bortezomib induces in HepG2 cells IkappaBalpha degradation mediated by caspase-8
Mol. Cell. Biochem.
287
13-19
2006
Homo sapiens
Byun, H.S.; Song, J.K.; Kim, Y.R.; Piao, L.; Won, M.; Park, K.A.; Choi, B.L.; Lee, H.; Hong, J.H.; Park, J.; Seok, J.H.; Lee, Y.J.; Kang, S.W.; Hur, G.M.
Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes
Rheumatology
47
301-308
2008
Homo sapiens
Kuckleburg, C.J.; Tiwari, R.; Czuprynski, C.J.
Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species
Thromb. Haemost.
99
363-372
2008
Bos taurus
Sheng, Z.; Cao, X.; Peng, S.; Wang, C.; Li, Q.; Wang, Y.; Liu, M.
Ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway
Toxicol. Appl. Pharmacol.
226
119-127
2008
Oryctolagus cuniculus
Capper, D.; Gaiser, T.; Hartmann, C.; Habel, A.; Mueller, W.; Herold-Mende, C.; von Deimling, A.; Siegelin, M.D.
Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation
Acta Neuropathol.
117
445-456
2009
Homo sapiens
Fan, J.P.; Kim, H.S.; Han, G.D.
Induction of apoptosis by L-carnitine through regulation of two main pathways in Hepa1c1c 7 cells
Amino Acids
36
365-372
2009
Mus musculus
Abe, A.; Yamada, H.
Harmol induces apoptosis by caspase-8 activation independently on Fas/Fas ligand interaction in human lung carcinoma H596 cells
Anticancer Drugs
20
373-381
2009
Homo sapiens
Johnke, R.M.; Smith, E.S.; Cariveau, M.J.; Evans, M.J.; Kilburn, J.M.; Bakken, N.T.; Nangami, G.N.
Radioprotection of murine gastrointestinal epithelium by interleukin-1alpha involves down-regulation of the apoptotic response
Anticancer Res.
28
3601-3607
2009
Mus musculus, Mus musculus C57BL/6
Cheah, Y.H.; Nordin, F.J.; Tee, T.T.; Azimahtol, H.L.; Abdullah, N.R.; Ismail, Z.
Antiproliferative property and apoptotic effect of xanthorrhizol on MDA-MB-231 breast cancer cells
Anticancer Res.
28
3677-3689
2009
Homo sapiens
Ideo, A.; Hashimoto, K.; Shimada, J.; Kawase, M.; Sakagami, H.
Type of cell death induced by alpha-trifluoromethyl acyloins in oral squamous cell carcinoma
Anticancer Res.
29
175-181
2009
Homo sapiens
Calafat, M.; Larocca, L.; Roca, V.; Hauk, V.; Pregi, N.; Nesse, A.; Perez Leiros, C.
Vasoactive intestinal peptide inhibits tumor necrosis factor-alpha-induced apoptotic events in acinar cells from non-obese diabetic mice submandibular glands
Arthritis Res. Ther.
11
R53
2009
Mus musculus
Artwohl, M.; Lindenmair, A.; Roden, M.; Waldhaeusl, W.K.; Freudenthaler, A.; Klosner, G.; Ilhan, A.; Luger, A.; Baumgartner-Parzer, S.M.
Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure
Atherosclerosis
202
351-362
2009
Homo sapiens
Beurel, E.; Blivet-Van Eggelpoel, M.J.; Kornprobst, M.; Moritz, S.; Delelo, R.; Paye, F.; Housset, C.; Desbois-Mouthon, C.
Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells
Biochem. Pharmacol.
77
54-65
2009
Homo sapiens
Balsas, P.; Lopez-Royuela, N.; Galan-Malo, P.; Anel, A.; Marzo, I.; Naval, J.
Cooperation between Apo2L/TRAIL and bortezomib in multiple myeloma apoptosis
Biochem. Pharmacol.
77
804-812
2009
Homo sapiens
Chen, X.Y.; Yang, H.X.; Qu, S.F.; Liu, J.; Lv, P.; Xu, J.P.; Xu, K.S.
Involvement of p38 and c-Jun N-terminal protein kinase in cardiotoxin III-induced apoptosis of K562 cells
Biol. Pharm. Bull.
32
583-588
2009
Homo sapiens
Carlucci, F.; Marinello, E.; Tommassini, V.; Pisano, B.; Rosi, F.; Tabucchi, A.
A 57-gene expression signature in B-cell chronic lymphocytic leukemia
Biomed. Pharmacother.
63
663-671
2009
Homo sapiens
Bonofiglio, D.; Gabriele, S.; Aquila, S.; Qi, H.; Belmonte, M.; Catalano, S.; Ando, S.
Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells
Breast Cancer Res. Treat.
113
423-434
2009
Homo sapiens
Fuchs, O.; Provaznikova, D.; Marinov, I.; Kuzelova, K.; Spicka, I.
Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells
Cardiovasc. Hematol. Disord. Drug Targets
9
62-77
2009
Homo sapiens
Inoue, S.; Browne, G.; Melino, G.; Cohen, G.M.
Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway
Cell Death Differ.
16
1053-1061
2009
Homo sapiens
Choi, E.J.; Ahn, W.S.; Bae, S.M.
Equol induces apoptosis through cytochrome c-mediated caspases cascade in human breast cancer MDA-MB-453 cells
Chem. Biol. Interact.
177
7-11
2009
Homo sapiens
Goel, A.; Prasad, A.K.; Parmar, V.S.; Ghosh, B.; Saini, N.
Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-kappaB, Akt, ROS and MAP kinase pathway
Chem. Biol. Interact.
179
363-374
2009
Homo sapiens
Huang, S.; Okumura, K.; Sinicrope, F.A.
BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells
Clin. Cancer Res.
15
150-159
2009
Homo sapiens
Chen, Y.X.; Lv, W.G.; Chen, H.Z.; Ye, F.; Xie, X.
Methotrexate induces apoptosis of human choriocarcinoma cell line JAR via a mitochondrial pathway
Eur. J. Obstet. Gynecol. Reprod. Biol.
143
107-111
2009
Homo sapiens
Fuccio, C.; Luongo, C.; Capodanno, P.; Giordano, C.; Scafuro, M.A.; Siniscalco, D.; Lettieri, B.; Rossi, F.; Maione, S.; Berrino, L.
A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice
Eur. J. Pharmacol.
603
42-49
2009
Mus musculus
Jen, C.Y.; Lin, C.Y.; Leu, S.F.; Huang, B.M.
Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis through caspase-9 pathway
Evid. Based. Complement Alternat. Med.
2009
1-10
2009
Mus musculus
Jia, J.; Guan, D.; Zhu, W.; Alkayed, N.J.; Wang, M.M.; Hua, Z.; Xu, Y.
Estrogen inhibits Fas-mediated apoptosis in experimental stroke
Exp. Neurol.
215
48-52
2009
Mus musculus
French, C.J.; Spees, J.L.; Zaman, A.K.; Taatjes, D.J.; Sobel, B.E.
The magnitude and temporal dependence of apoptosis early after myocardial ischemia with or without reperfusion
FASEB J.
23
1177-1185
2009
Mus musculus, Mus musculus C57BL6
Chen, N.; Gong, J.; Chen, X.; Meng, W.; Huang, Y.; Zhao, F.; Wang, L.; Zhou, Q.
Caspases and inhibitor of apoptosis proteins in cutaneous and mucosal melanoma: expression profile and clinicopathologic significance
Hum. Pathol.
40
950-956
2009
Homo sapiens
Jin, D.; Ojcius, D.M.; Sun, D.; Dong, H.; Luo, Y.; Mao, Y.; Yan, J.
Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways
Infect. Immun.
77
799-809
2009
Homo sapiens, Mus musculus
Albrecht, E.A.; Sarma, J.V.; Ward, P.A.
Activation by C5a of endothelial cell caspase 8 and cFLIP
Inflamm. Res.
58
30-37
2009
Homo sapiens
Cardenas, M.G.; Zotta, E.; Marder, M.; Roguin, L.P.
In vitro induction of apoptosis and in vivo effects of a flavone nitroderivative in murine mammary adenocarcinoma cells
Int. J. Cancer
125
222-228
2009
Mus musculus, Mus musculus BALB/c
Hu, G.; Barnes, B.J.
IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway
J. Biol. Chem.
284
2767-2777
2009
Homo sapiens
Kadohara, K.; Nagumo, M.; Asami, S.; Tsukumo, Y.; Sugimoto, H.; Igarashi, M.; Nagai, K.; Kataoka, T.
Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells
J. Biol. Chem.
284
5478-5487
2009
Homo sapiens
Anathy, V.; Aesif, S.W.; Guala, A.S.; Havermans, M.; Reynaert, N.L.; Ho, Y.S.; Budd, R.C.; Janssen-Heininger, Y.M.
Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas
J. Cell Biol.
184
241-252
2009
Homo sapiens
Alam, M.M.; Mohammad, A.A.; Shuaib, U.; Wang, C.; Ghani, U.; Schwindt, B.; Todd, K.G.; Shuaib, A.
Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis
J. Cereb. Blood Flow Metab.
29
157-165
2009
Homo sapiens
An, J.; Li, P.; Li, J.; Dietz, R.; Donath, S.
ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity
J. Mol. Med.
87
401-410
2009
Rattus norvegicus
Delloye-Bourgeois, C.; Brambilla, E.; Coissieux, M.M.; Guenebeaud, C.; Pedeux, R.; Firlej, V.; Cabon, F.; Brambilla, C.; Mehlen, P.; Bernet, A.
Interference with netrin-1 and tumor cell death in non-small cell lung cancer
J. Natl. Cancer Inst.
101
237-247
2009
Homo sapiens
Ho, C.C.; Rideout, H.J.; Ribe, E.; Troy, C.M.; Dauer, W.T.
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
J. Neurosci.
29
1011-1016
2009
Homo sapiens
Heo, S.K.; Yun, H.J.; Park, W.H.; Park, S.D.
Rhein inhibits TNF-alpha-induced human aortic smooth muscle cell proliferation via mitochondrial-dependent apoptosis
J. Vasc. Res.
46
375-386
2009
Homo sapiens
Gupta, S.; Agrawal, S.; Gollapudi, S.
Differential effect of human herpesvirus 6A on cell division and apoptosis among naive and central and effector memory CD4+ and CD8+ T-cell subsets
J. Virol.
83
5442-5450
2009
Homo sapiens
Chen, Y.W.; Lin, G.J.; Chia, W.T.; Lin, C.K.; Chuang, Y.P.; Sytwu, H.K.
Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo
Oral Oncol.
45
562-568
2009
Homo sapiens
Kamimatsuse, A.; Matsuura, K.; Moriya, S.; Fukuba, I.; Yamaoka, H.; Fukuda, E.; Kamei, N.; Hiyama, K.; Sueda, T.; Hiyama, E.
Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array
Pediatr. Blood Cancer
52
777-783
2009
Homo sapiens
Gajate, C.; Gonzalez-Camacho, F.; Mollinedo, F.
Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells
PLoS ONE
4
e5044
2009
Homo sapiens
Guerleyen, H.; Christiansen, H.; Tello, K.; Dudas, J.; Hermann, R.M.; Rave-Fraenk, M.; Hess, C.F.; Ramadori, G.; Saile, B.
Irradiation leads to sensitization of hepatocytes to TNF-alpha-mediated apoptosis by upregulation of IkappaB expression
Radiat. Environ. Biophys.
48
85-94
2009
Rattus norvegicus
Garcia, S.; Mera, A.; Gomez-Reino, J.J.; Conde, C.
Poly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis
Rheumatology
48
483-489
2009
Homo sapiens
Chattopadhyay, R.; Bhattacharyya, A.; Crowe, S.E.
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection
Cancer Res.
70
2799-2808
2010
Homo sapiens
Chaopatchayakul, P.; Jearanaikoon, P.; Yuenyao, P.; Limpaiboon, T.
Aberrant DNA methylation of apoptotic signaling genes in patients responsive and nonresponsive to therapy for cervical carcinoma
Am. J. Obstet. Gynecol.
202
281e1-281e9
2010
Homo sapiens
Christensen, H.M.; Dikranian, K.; Li, A.; Baysac, K.C.; Walls, K.C.; Olney, J.W.; Roth, K.A.; Harris, D.A.
A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death
Am. J. Pathol.
176
2695-2706
2010
Mus musculus
Esaki, S.; Goshima, F.; Katsumi, S.; Watanabe, D.; Ozaki, N.; Murakami, S.; Nishiyama, Y.
Apoptosis induction after herpes simplex virus infection differs according to cell type in vivo
Arch. Virol.
155
1235-1245
2010
Mus musculus
Esposti, D.D.; Domart, M.C.; Sebagh, M.; Harper, F.; Pierron, G.; Brenner, C.; Lemoine, A.
Autophagy is induced by ischemic preconditioning in human livers formerly treated by chemotherapy to limit necrosis
Autophagy
6
172-174
2010
Homo sapiens
Ghavami, S.; Mutawe, M.M.; Hauff, K.; Stelmack, G.L.; Schaafsma, D.; Sharma, P.; McNeill, K.D.; Hynes, T.S.; Kung, S.K.; Unruh, H.; Klonisch, T.; Hatch, G.M.; Los, M.; Halayko, A.J.
Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c
Biochim. Biophys. Acta
1803
452-467
2010
Homo sapiens
Chauhan, D.; Singh, A.V.; Ciccarelli, B.; Richardson, P.G.; Palladino, M.A.; Anderson, K.C.
Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
Blood
115
834-845
2010
Homo sapiens
Chang, K.C.; Lo, C.W.; Fan, T.C.; Chang, M.D.; Shu, C.W.; Chang, C.H.; Chung, C.T.; Fang, S.L.; Chao, C.C.; Tsai, J.J.; Lai, Y.K.
TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells
BMC Cell Biol.
11
6-6
2010
Homo sapiens
Grisendi, G.; Bussolari, R.; Cafarelli, L.; Petak, I.; Rasini, V.; Veronesi, E.; De Santis, G.; Spano, C.; Tagliazzucchi, M.; Barti-Juhasz, H.; Scarabelli, L.; Bambi, F.; Frassoldati, A.; Rossi, G.; Casali, C.; Morandi, U.; Horwitz, E.M.; Paolucci, P.; Conte, P.; Dominici, M.
Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy
Cancer Res.
70
3718-3729
2010
Homo sapiens
Assayag, M.; Gerstenblith, G.; Stern, M.D.; Horowitz, M.
Long- but not short-term heat acclimation produces an apoptosis-resistant cardiac phenotype: a lesson from heat stress and ischemic/reperfusion insults
Cell Stress Chaperones
15
651-664
2010
Rattus norvegicus
Boehme, L.; Albrecht, M.; Riede, O.; Rudel, T.
Chlamydia trachomatis-infected host cells resist dsRNA-induced apoptosis
Cell. Microbiol.
12
1340-1351
2010
Homo sapiens
Eley, H.L.; Russell, S.T.; Tisdale, M.J.
Mechanism of activation of dsRNA-dependent protein kinase (PKR) in muscle atrophy
Cell. Signal.
22
783-790
2010
Mus musculus
Ahmed, K.; Wei, Z.L.; Zhao, Q.L.; Nakajima, N.; Matsunaga, T.; Ogasawara, M.; Kondo, T.
Role of fatty acid chain length on the induction of apoptosis by newly synthesized catechin derivatives
Chem. Biol. Interact.
185
182-188
2010
Homo sapiens
Bidle, K.A.; Haramaty, L.; Baggett, N.; Nannen, J.; Bidle, K.D.
Tantalizing evidence for caspase-like protein expression and activity in the cellular stress response of Archaea
Environ. Microbiol.
12
1161-1172
2010
Homo sapiens (Q14790), Homo sapiens
Bai, J.; Meng, Z.
Expression of caspase and apoptotic signal pathway induced by sulfur dioxide
Environ. Mol. Mutagen.
51
112-122
2010
Rattus norvegicus (Q9JHX4), Rattus norvegicus
Cagnol, S.; Chambard, J.C.
ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence
FEBS J.
277
2-21
2010
Homo sapiens
Ding, D.; Jiang, H.; Salvi, R.J.
Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid
Hear. Res.
259
16-23
2010
Chinchilla lanigera
Brugnon, F.; Janny, L.; Communal, Y.; Darcha, C.; Szczepaniak, C.; Pellestor, F.; Vago, P.; Pons-Rejraji, H.; Artonne, C.; Grizard, G.
Apoptosis and meiotic segregation in ejaculated sperm from Robertsonian translocation carrier patients
Hum. Reprod.
25
1631-1642
2010
Homo sapiens
Binet, F.; Chiasson, S.; Girard, D.
Arsenic trioxide induces endoplasmic reticulum stress-related events in neutrophils
Int. Immunopharmacol.
10
508-512
2010
Homo sapiens
Darvas, K.; Rosenberger, S.; Brenner, D.; Fritsch, C.; Gmelin, N.; Krammer, P.H.; Roesl, F.
Histone deacetylase inhibitor-induced sensitization to TNFalpha/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression
Int. J. Cancer
127
1384-1392
2010
Homo sapiens
Gallego, B.; Kaluderovic, M.R.; Kommera, H.; Paschke, R.; Hey-Hawkins, E.; Remmerbach, T.W.; Kaluderovic, G.N.; Gomez-Ruiz, S.
Cytotoxicity, apoptosis and study of the DNA-binding properties of bi- and tetranuclear gallium(III) complexes with heterocyclic thiolato ligands
Invest. New Drugs
29
932-944
2011
Homo sapiens
Couturier, J.; Morel, M.; Pontcharraud, R.; Gontier, V.; Fauconneau, B.; Paccalin, M.; Page, G.
Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice
J. Biol. Chem.
285
1272-1282
2010
Mus musculus
Bleicken, S.; Classen, M.; Padmavathi, P.V.; Ishikawa, T.; Zeth, K.; Steinhoff, H.J.; Bordignon, E.
Molecular details of Bax activation, oligomerization, and membrane insertion
J. Biol. Chem.
285
6636-6647
2010
Homo sapiens
Chen, M.C.; Yu, C.H.; Wang, S.W.; Pu, H.F.; Kan, S.F.; Lin, L.C.; Chi, C.W.; Ho, L.L.; Lee, C.H.; Wang, P.S.
Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO
J. Cell. Biochem.
110
1495-1503
2010
Homo sapiens
Chang, S.H.; Bae, J.H.; Hong, D.P.; Choi, K.D.; Kim, S.C.; Her, E.; Kim, S.H.; Kang, C.D.
Dryopteris crassirhizoma has anti-cancer effects through both extrinsic and intrinsic apoptotic pathways and G0/G1 phase arrest in human prostate cancer cells
J. Ethnopharmacol.
130
248-254
2010
Homo sapiens
Bai, X.; Kim, S.H.; Azam, T.; McGibney, M.T.; Huang, H.; Dinarello, C.A.; Chan, E.D.
IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages
J. Immunol.
184
3830-3840
2010
Homo sapiens
Al-Dhaheri, R.S.; Douglas, L.J.
Apoptosis in Candida biofilms exposed to amphotericin B
J. Med. Microbiol.
59
149-157
2010
Candida albicans, Candida albicans GDH 2346, Candida parapsilosis, Candida parapsilosis AAHB 4479, Pichia kudriavzevii, Pichia kudriavzevii Glasgow
Camina-Tato, M.; Fernandez, M.; Morcillo-Suarez, C.; Navarro, A.; Julia, E.; Edo, M.C.; Montalban, X.; Comabella, M.
Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis
J. Neuroimmunol.
222
70-75
2010
Homo sapiens
Chae, S.S.; Yoo, C.B.; Jo, C.; Yun, S.M.; Jo, S.A.; Koh, Y.H.
Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis
J. Neurosci. Res.
88
1926-1933
2010
Homo sapiens
George, J.; Banik, N.L.; Ray, S.K.
Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells
J. Neurosci. Res.
88
877-886
2010
Homo sapiens
Calenic, B.; Yaegaki, K.; Murata, T.; Imai, T.; Aoyama, I.; Sato, T.; Ii, H.
Oral malodorous compound triggers mitochondrial-dependent apoptosis and causes genomic DNA damage in human gingival epithelial cells
J. Periodontal Res.
45
31-37
2010
Homo sapiens
Barry, G.; Fragkoudis, R.; Ferguson, M.C.; Lulla, A.; Merits, A.; Kohl, A.; Fazakerley, J.K.
Semliki Forest virus induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells
J. Virol.
84
7369-7377
2010
Mus musculus
Aguzzi, M.S.; Fortugno, P.; Giampietri, C.; Ragone, G.; Capogrossi, M.C.; Facchiano, A.
Intracellular targets of RGDS peptide in melanoma cells
Mol. Cancer
9
84
2010
Homo sapiens
Bijangi-Vishehsaraei, K.; Saadatzadeh, M.R.; Huang, S.; Murphy, M.P.; Safa, A.R.
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells
Mol. Cell. Biochem.
342
133-142
2010
Homo sapiens
Apolloni, S.; Finocchi, P.; DAgnano, I.; Alloisio, S.; Nobile, M.; DAmbrosi, N.; Volonte, C.
UDP exerts cytostatic and cytotoxic actions in human neuroblastoma SH-SY5Y cells over-expressing P2Y6 receptor
Neurochem. Int.
56
670-678
2010
Homo sapiens
Barca, O.; Carneiro, C.; Costoya, J.A.; Senaris, R.M.; Arce, V.M.
Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8
Neurosci. Lett.
479
206-210
2010
Rattus norvegicus
Banerjee, M.; Datta, M.; Majumder, P.; Mukhopadhyay, D.; Bhattacharyya, N.P.
Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1
Nucleic Acids Res.
38
878-892
2010
Homo sapiens
Aoyama, M.; Kotani, J.; Usami, M.
Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways
Nutrition
26
653-661
2010
Homo sapiens
Giotakis, J.; Gomatos, I.P.; Alevizos, L.; Georgiou, A.N.; Leandros, E.; Konstadoulakis, M.M.; Manolopoulos, L.
Bax, cytochrome c, and caspase-8 staining in parotid cancer patients: markers of susceptibility in radiotherapy?
Otolaryngol. Head Neck Surg.
142
605-611
2010
Homo sapiens
Cho, S.; Lee, J.H.; Cho, S.B.; Yoon, K.W.; Park, S.Y.; Lee, W.S.; Park, C.H.; Joo, Y.E.; Kim, H.S.; Choi, S.K.; Rew, J.S.
Epigenetic methylation and expression of caspase 8 and survivin in hepatocellular carcinoma
Pathol. Int.
60
203-211
2010
Homo sapiens
Ceron, J.M.; Contreras-Moreno, J.; Puertollano, E.; Cienfuegos, G.A.; Puertollano, M.A.; de Pablo, M.A.
The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells
Peptides
31
1494-1503
2010
Homo sapiens
Gauster, M.; Huppertz, B.
The paradox of caspase 8 in human villous trophoblast fusion
Placenta
31
82-88
2010
Homo sapiens
Danelishvili, L.; Yamazaki, Y.; Selker, J.; Bermudez, L.E.
Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis
PLoS ONE
5
e10474
2010
Homo sapiens
Gonzalvez, F.; Pariselli, F.; Jalmar, O.; Dupaigne, P.; Sureau, F.; Dellinger, M.; Hendrickson, E.A.; Bernard, S.; Petit, P.X.
Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin
PLoS ONE
5
e9342
2010
Mus musculus
Chen, S.C.; Chen, C.H.; Tioh, Y.L.; Zhong, P.Y.; Lin, Y.S.; Chye, S.M.
Para-phenylenediamine induced DNA damage and apoptosis through oxidative stress and enhanced caspase-8 and -9 activities in Mardin-Darby canine kidney cells
Toxicol. In Vitro
24
1197-1202
2010
Canis lupus familiaris
Chan, K.M.; Rajab, N.F.; Siegel, D.; Din, L.B.; Ross, D.; Inayat-Hussain, S.H.
Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway
Toxicol. Sci.
116
533-548
2010
Homo sapiens
Fang, X.; Feng, Y.; Wang, J.; Dai, J.
Perfluorononanoic acid-induced apoptosis in rat spleen involves oxidative stress and the activation of caspase-independent death pathway
Toxicology
267
54-59
2010
Rattus norvegicus
Bertollo, C.M.; Correa, C.R.; Gomes, D.A.; Souza-Fagundes, E.M.; Goes, A.M.
Effect of radiation treatment on newly established human breast cancer cell lines MACL-1 and MGSO-3
Tumour Biol.
31
189-197
2010
Homo sapiens
Pop, C.; Oberst, A.; Drag, M.; Van Raam, B.J.; Riedl, S.J.; Green, D.R.; Salvesen, G.S.
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
Biochem. J.
433
447-457
2011
Mus musculus
Wang, Z.; Watt, W.; Brooks, N.A.; Harris, M.S.; Urban, J.; Boatman, D.; McMillan, M.; Kahn, M.; Heinrikson, R.L.; Finzel, B.C.; Wittwer, A.J.; Blinn, J.; Kamtekar, S.; Tomasselli, A.G.
Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors
Biochim. Biophys. Acta
1804
1817-1831
2010
Homo sapiens
Kantari, C.; Walczak, H.
Caspase-8 and Bid: caught in the act between death receptors and mitochondria
Biochim. Biophys. Acta
1813
558-563
2011
Homo sapiens
van Raam, B.J.; Salvesen, G.S.
Proliferative versus apoptotic functions of caspase-8 hetero or homo: the caspase-8 dimer controls cell fate
Biochim. Biophys. Acta
1824
113-122
2012
Homo sapiens, Mus musculus
Kober, A.M.; Legewie, S.; Pforr, C.; Fricker, N.; Eils, R.; Krammer, P.H.; Lavrik, I.N.
Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation
Cell Death Dis.
2
e212
2011
Homo sapiens
Wu, Y.; Wang, D.; Wang, X.; Wang, Y.; Ren, F.; Chang, D.; Chang, Z.; Jia, B.
Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells
Cell. Physiol. Biochem.
27
539-546
2011
Homo sapiens
Edelmann, B.; Bertsch, U.; Tchikov, V.; Winoto-Morbach, S.; Perrotta, C.; Jakob, M.; Adam-Klages, S.; Kabelitz, D.; Schuetze, S.
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes
EMBO J.
30
379-394
2011
Homo sapiens
Guicciardi, M.E.; Mott, J.L.; Bronk, S.F.; Kurita, S.; Fingas, C.D.; Gores, G.J.
Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
Exp. Cell Res.
317
107-116
2011
Homo sapiens (Q14790), Homo sapiens
Akagi, T.; Shimizu, K.; Takahama, S.; Iwasaki, T.; Sakamaki, K.; Endo, Y.; Sawasaki, T.
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling
FEBS Lett.
585
1835-1840
2011
Homo sapiens
Zhao, Y.; Sui, X.; Ren, H.
From procaspase-8 to caspase-8: revisiting structural functions of caspase-8
J. Cell. Physiol.
225
316-320
2010
Homo sapiens
O'Donnell, M.A.; Perez-Jimenez, E.; Oberst, A.; Ng, A.; Massoumi, R.; Xavier, R.; Green, D.R.; Ting, A.T.
Caspase 8 inhibits programmed necrosis by processing CYLD
Nat. Cell Biol.
13
1437-1442
2011
Homo sapiens, Mus musculus
Oberst, A.; Green, D.R.
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
Nat. Rev. Mol. Cell Biol.
12
757-763
2011
Homo sapiens
Oral, O.; Oz-Arslan, D.; Itah, Z.; Naghavi, A.; Deveci, R.; Karacali, S.; Gozuacik, D.
Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death
Apoptosis
17
810-820
2012
Homo sapiens (Q14790)
Ahmad, K.; Khan, S.; Adil, M.; Saeed, M.; Srivastava, A.K.
Structure based molecular inhibition of Caspase-8 for treatment of multi-neurodegenerative diseases using known natural compounds
Bioinformation
10
191-195
2014
Homo sapiens (Q14790)
Beaudouin, J.; Liesche, C.; Aschenbrenner, S.; Hoerner, M.; Eils, R.
Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis
Cell Death Differ.
20
599-610
2013
Homo sapiens
Li, X.; Zhao, Y.; Zhang, Y.; Du, N.; Ren, H.
Tumor necrosis factor alpha stimulates Her-2 cleavage by activated caspase-8
Cell. Physiol. Biochem.
30
889-897
2012
Homo sapiens
Zhang, D.; Wang, H.W.; Yao, C.L.
Molecular and acute temperature stress response characterizations of caspase-8 gene in two mussels, Mytilus coruscus and Mytilus galloprovincialis
Comp. Biochem. Physiol. B
177-178
10-20
2014
Mytilus galloprovincialis (A0A097BW92), Mytilus galloprovincialis, Mytilus coruscus (A0A097BW98), Mytilus coruscus
Cuda, C.M.; Misharin, A.V.; Gierut, A.K.; Saber, R.; Haines, G.K.; Hutcheson, J.; Hedrick, S.M.; Mohan, C.; Budinger, G.S.; Stehlik, C.; Perlman, H.
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation
J. Immunol.
192
5548-5560
2014
Mus musculus (O89110)
Shen, C.; Yue, H.; Pei, J.; Guo, X.; Wang, T.; Quan, J.M.
Crystal structure of the death effector domains of caspase-8
Biochem. Biophys. Res. Commun.
463
297-302
2015
Homo sapiens (Q14790)
Park, H.H.
Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain
Cell Death Differ.
26
1213-1220
2019
Homo sapiens (Q14790)
Horn, S.; Hughes, M.A.; Schilling, R.; Sticht, C.; Tenev, T.; Ploesser, M.; Meier, P.; Sprick, M.R.; MacFarlane, M.; Leverkus, M.
Caspase-10 negatively regulates caspase-8-mediated cell death, switching the response to CD95L in favor of NF-kappaB activation and cell survival
Cell Rep.
19
785-797
2017
Homo sapiens (Q14790)
Saavedra, E.; Del Rosario, H.; Brouard, I.; Quintana, J.; Estevez, F.
6-Benzyloxy-4-bromo-2-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis
Chem. Biol. Interact.
298
137-145
2019
Homo sapiens (Q14790)
Carrillo, I.; Droguett, D.; Castillo, C.; Liempi, A.; Munoz, L.; Maya, J.D.; Galanti, N.; Kemmerling, U.
Caspase-8 activity is part of the BeWo trophoblast cell defense mechanisms against Trypanosoma cruzi infection
Exp. Parasitol.
168
9-15
2016
Homo sapiens (Q14790)
Sun, S.; Ge, X.; Zhu, J.; Zhang, W.; Zhang, Q.
Molecular cloning, immunohistochemical localization, characterization and expression analysis of caspase-8 from the blunt snout bream (Megalobrama amblycephala) exposed to ammonia
Fish Shellfish Immunol.
47
645-654
2015
Megalobrama amblycephala
Wei, X.; Li, Q.; Han, Z.; Lin, D.; Yu, P.
Differences in caspase-8 and -9 activity and sperm motility in infertile males of Li nationality in China
Int. J. Clin. Exp. Med.
8
4721-4726
2015
Homo sapiens (Q14790), Homo sapiens
Huang, K.; Zhang, J.; ONeill, K.L.; Gurumurthy, C.B.; Quadros, R.M.; Tu, Y.; Luo, X.
Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein Bid during TRAIL-induced apoptosis
J. Biol. Chem.
291
11843-11851
2016
Homo sapiens (Q14790)
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