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Literature summary for 3.4.22.61 extracted from

  • Himeji, D.; Horiuchi, T.; Tsukamoto, H.; Hayashi, K.; Watanabe, T.; Harada, M.
    Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade (2002), Blood, 99, 4070-4078.
    View publication on PubMed
Search for more literature for 3.4.22.61

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-8L acts as an inhibitor of caspase-8 by interfering with the binding of caspase-8 to FADD, i.e. Fas-associated protein with death domain, and is involved in the regulation of Fas-mediated apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-
peripheral blood lymphocyte caspase-8L is generated by the alternative splicing of human caspase-8 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IETD-4-nitroanilide + H2O
-
 Homo sapiens IETD + 4-nitroaniline
-
 ?
additional information caspase-8L acts as an inhibitor of caspase-8 by interfering with the binding of caspase-8 to FADD, i.e. Fas-associated protein with death domain, and is involved in the regulation of Fas-mediated apoptosis Homo sapiens ?
-
 ?