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Literature summary for 3.4.22.61 extracted from
- Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma (2010), Blood, 115, 834-845.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| IETD-fluoromethylketone | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| multiple myeloma cell | - |
Homo sapiens | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | NPI-0052 plus lenalidomide-induced apoptosis is associated with activation of caspase-8 | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | NPI-0052 plus lenalidomide-triggered apoptosis is primarily dependent on caspase-8 signaling | Homo sapiens |
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Release 2023.1 (January 2023)
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