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3.4.22.61: caspase-8

This is an abbreviated version!
For detailed information about caspase-8, go to the full flat file.

Word Map on EC 3.4.22.61

Reaction

strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-/-(Gly/Ser/Ala) =

Synonyms

apoptotic cysteine protease, apoptotic protease Mch-5, C14.004, CAP4, Casp8, caspase 8, caspase-8, cysteine aspartic acid protease 8, cysteine aspartic acid-specific protease, cysteine protease caspase-8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLICE/MACH, ICE-like apoptotic protease 5, MACH, Mch5, More, MORT1-associated CED-3 homolog

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.61 caspase-8

Molecular Weight

Molecular Weight on EC 3.4.22.61 - caspase-8

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11000
alpha2beta2, 2 * 18000 + 2 * 11000, crystallographic data
18000
28000
activated heterodimer, gel filtration
31000
monomer, non-cleavable caspase-8, SDS-PAGE
41000
-
x * 41000 + x * 43000, cleaved caspase-8, SDS-PAGE
43000
54000
monomer, pro-caspase-8, SDS-PAGE
55000
55820
x * 55820, calculated from amino acid sequence
56180
x * 56180, calculated from amino acid sequence
57000