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Literature summary for 3.4.22.61 extracted from
- Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells (2010), J. Neurosci. Res., 88, 877-886.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Bid peptide + H2O | Homo sapiens | - |
truncated Bid peptide + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| SK-N-DZ cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Bid peptide + H2O | - |
Homo sapiens | truncated Bid peptide + ? | - |
? | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | genistein triggers the receptor-mediated apoptotic pathway through activation of caspase-8, the highest activation of caspase-8 occurs after treatment with the combination of Bcl-2 siRNA and genistein (0.01 mM) | up |
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