3.4.21.B7: mannan-binding lectin-associated serine protease 1
This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.
Word Map on EC 3.4.21.B7
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3.4.21.B7
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masp-3
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silk
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spider
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ficolins
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dragline
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c1s
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ampullate
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spidroins
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convertase
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collagen-like
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clavipes
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collectins
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m-ficolin
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autoactivation
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nephila
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subcomponents
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complement-activating
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c1-inhibitor
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latrodectus
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pattern-recognition
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widow
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fibrinogen-like
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protease-2
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opsonin
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extensibility
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urochord
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c1-inh
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hesperus
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medicine
- 3.4.21.B7
- masp-3
-
silk
- spider
- ficolins
-
dragline
- c1s
-
ampullate
-
spidroins
-
convertase
-
collagen-like
- clavipes
-
collectins
- m-ficolin
-
autoactivation
- nephila
-
subcomponents
-
complement-activating
- c1-inhibitor
- latrodectus
-
pattern-recognition
- widow
-
fibrinogen-like
-
protease-2
-
opsonin
-
extensibility
-
urochord
-
c1-inh
- hesperus
- medicine
Reaction
endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =
Synonyms
mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198
ECTree
3.4.21.B7 mannan-binding lectin-associated serine protease 1Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
high-molecular weight kininogen + H2O
bradykinin + ?
a noncomplement substrate, activation
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-
?
low-molecular-weight kininogen + H2O
?
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the cleavage rate of low-molecular-weight kininogen by MASP-1 is about 5times lower than that of kininogen
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?
MASP-2 zymogen + H2O
mature MASP-2 + ?
MASP-2 is a key enzyme that cleaves C4 and C2 to assemble a C3 convertase
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-
?
proform coagulation factor XIII + H2O
mature coagulation factor XIII + ?
a noncomplement substrate, activation
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-
?
proform mannan-binding lectin-associated serine protease 1 + H2O
mature mannan-binding lectin-associated serine protease 1 + ?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
proform mannan-binding lectin-associated serine protease 3 + H2O
mature mannan-binding lectin-associated serine protease 3 + ?
a complement substrate, activation
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-
?
proform protease activated receptor 4 + H2O
mature protease activated receptor 4 + ?
activation
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?
proform thrombin-activatable fibrinolysis inhibitor + H2O
mature thrombin-activatable fibrinolysis inhibitor + ?
activation
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?
protease activated receptor 4 + H2O
?
PAR4, a noncomplement substrate, activation
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?
prothrombin + H2O
thrombin a + ?
enzyme MASP-1 cleaves prothrombinat three cleavage sites, MASP-1 gives rise to an alternative active form of thrombin by cleaving at the cleavage site R393
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?
fibrinogen + H2O
fibrin + ?
MASP-1-induced fibrin formation and activation is thrombin-dependent, in plasma environment fibrin formation is not directly induced by MASP-1 in the absence of prothrombin
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-
?
proform mannan-binding lectin-associated serine protease 1 + H2O
mature mannan-binding lectin-associated serine protease 1 + ?
autocatalytic cleavage, a complement substrate, activation
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-
?
proform mannan-binding lectin-associated serine protease 1 + H2O
mature mannan-binding lectin-associated serine protease 1 + ?
-
autocatalytic cleavage, a complement substrate, activation
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-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
a complement substrate, activation
-
-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
-
a complement substrate, activation
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-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
enzyme MASP-1 is the main activator of MASP-2
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?
prothrombin + H2O
thrombin + ?
a noncomplement substrate, activation
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?
additional information
?
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complexes with mannose-binding lectin in the presence of Ca2+, involved in activation of complement cascade
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?
additional information
?
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involved in activation of complement cascade
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?
additional information
?
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involved in activation of complement cascade
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?
additional information
?
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involved in activation of complement cascade, circulates in serum complexed with mannose-binding protein
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?
additional information
?
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involved in activation of complement cascade, forms a complex with mannose-binding lectin
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?
additional information
?
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involved in activation of complement cascade, smallest functional unit for complement activation consists of serum mannose-binding protein dimers bound to MASP-1 homodimers
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?
additional information
?
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MASP-1 shows no activity toward complement C4. MASP-1 collaborates with MASP-2 in the generation of C3 convertase, a process observable at high serum concentration, but not at low serum concentration
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?
additional information
?
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MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII
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?
additional information
?
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MASP-1 cannot cleave complement component C4, recombinant MASP-1 does not activate plasma prekallikrein
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?
additional information
?
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involved in activation of complement cascade
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?
additional information
?
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involved in activation of complement cascade
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?
additional information
?
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involved in activation of complement cascade, enzyme is complexed with the mannose-binding protein
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?
additional information
?
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involved in activation of complement cascade, enzyme is complexed with the mannose-binding protein
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?
additional information
?
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involved in activation of complement cascade, forms a complex with mannose-binding lectin
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?
additional information
?
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MASP-1 contributes to the activation of the lectin pathway, probably through the activation of MASP-2
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?
additional information
?
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MASP-1 contributes to the activation of the lectin pathway, probably through the activation of MASP-2
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?
additional information
?
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involved in activation of complement cascade, enzyme is complexed with the mannose-binding protein
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?
additional information
?
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involved in activation of complement cascade, circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a MASP homodimer bound to two mannose-binding protein trimeric subunits
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?
