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Literature summary for 3.4.21.B7 extracted from

  • Chen, C.B.; Wallis, R.
    Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases (2004), J. Biol. Chem., 279, 26058-26065.
    View publication on PubMed

Application

Application Comment Organism
additional information MASP-1 enhances complement activation triggered by mannose-binding protein-MASP-2 complexes, but cannot initiate activation itself Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information MASP-1 ent, catalytically active form of MASP-1 produced by substituting residues 425Lys-His-Ile-Ser-Arg Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
8.9
-
benzoyl-L-arginine p-nitroanilide cleavage by activated MASP-1 ent Rattus norvegicus
13
-
complement C2 cleavage by activated MASP-1 ent Rattus norvegicus
13
-
complement C2 complement component C2 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C2 + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by affinity chromatography Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-L-arginine p-nitroanilide + H2O
-
Rattus norvegicus benzoyl-L-arginine + 4-nitroaniline
-
?
complement component C2 + H2O
-
Rattus norvegicus ?
-
?
additional information no cleavage of complement C4 and N-alpha-carbobenzoxy-L-lysine p-nitropenhyl ester Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
MASP-1
-
Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.9
-
Complement component C2 cleavage by activated MASP-1 ent Rattus norvegicus
4.3
-
benzoyl-L-arginine p-nitroanilide cleavage by activated MASP-1 ent Rattus norvegicus