3.4.21.B7: mannan-binding lectin-associated serine protease 1
This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.
Word Map on EC 3.4.21.B7
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3.4.21.B7
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masp-3
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silk
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spider
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ficolins
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dragline
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c1s
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ampullate
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spidroins
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convertase
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collagen-like
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clavipes
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collectins
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m-ficolin
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autoactivation
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nephila
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subcomponents
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complement-activating
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c1-inhibitor
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latrodectus
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pattern-recognition
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widow
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fibrinogen-like
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protease-2
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opsonin
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extensibility
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urochord
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c1-inh
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hesperus
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medicine
- 3.4.21.B7
- masp-3
-
silk
- spider
- ficolins
-
dragline
- c1s
-
ampullate
-
spidroins
-
convertase
-
collagen-like
- clavipes
-
collectins
- m-ficolin
-
autoactivation
- nephila
-
subcomponents
-
complement-activating
- c1-inhibitor
- latrodectus
-
pattern-recognition
- widow
-
fibrinogen-like
-
protease-2
-
opsonin
-
extensibility
-
urochord
-
c1-inh
- hesperus
- medicine
Reaction
endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =
Synonyms
mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198
ECTree
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Inhibitors
Inhibitors on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1
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ACTRKLCW
a Schistocerca gregaria protease inhibitor-1 P4-P4' sequence mutant
alpha2-Macroglobulin
may be a physiological inhibitor, 1-3fold molar excess, forms a stable complex with the enzyme
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antithrombin III
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inhibitory in the presence of heparin on activity of MASP-1
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EDTA
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inhibits binding of MASP-1 to immobilized mannan-binding lectin and L-ficolin/P35, when substituted for Ca2+
lectin pathway C1-inhibitor
the inhibitor is not specific for MASP-1 versus MASP-2
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MCTRKLCW
a Schistocerca gregaria protease inhibitor-1 P4-P4' sequence mutant
MCTRKLCY
a Schistocerca gregaria protease inhibitor-1 P4-P4' sequence mutant
Schistocerca gregaria protease inhibitor-2 variant FCTRKLCY
randomization of positions P4, P2, P1, P1', P2', and P4' of the protease binding loop while keeping the structurally indispensable Cys at P3 and P3' leads to monospecific MASP inhibitors. Inhibitor variant FCTRKLCY is specific for isoform MASP-1, treatment completely blocks the lectin pathway activation, demonstrating that MASP-1 is not an auxiliary but an essential pathway component
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SGMI-1
selective MASP-1 inhibitor, based on the Schistocerca gregaria protease inhibitor scaffold
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VCTRLWCE
a sunflower MASP inhibitor-2 P4-P4' sequence mutant, only slight inhibition
VCTRLWCN
a sunflower MASP inhibitor-2 P4-P4' sequence mutant, only slight inhibition
VCTRLYCN
a sunflower MASP inhibitor-2 P4-P4' sequence mutant, only slight inhibition
C1-inhibitor
completely blocks enzyme activity, 1-3fold molar excess, forms a stable complex with the enzyme
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SGMI-1, sequence P4-P4' is FCTRKLCY, the structure of the MASP-1-SGMI-1 complex does not support the induced fit or conformational selection substrate-binding model, structure analysis, detailed overview
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Schistocerca gregaria protease inhibitor-1
SGMI-1, specific inhibition of MASP-1 isozyme
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additional information
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MASP-1 is not inhibited by sunflower MASP inhibitor-2
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additional information
no inhibition by Schistocerca gregaria protease inhibitor-2, SGMI-2, and sunflower MASP inhibitor-2, SFMI-2, but slight inhibition by inhibitor mutants, overview; Schistocerca gregaria protease inhibitor-2 variant VCTKLWCN is specific for isoform MASP-2 and not inhibitory for isoform MASP-1
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