Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.21.B7: mannan-binding lectin-associated serine protease 1

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.

Word Map on EC 3.4.21.B7

Reaction

endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =

Synonyms

mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B7 mannan-binding lectin-associated serine protease 1

Inhibitors

Inhibitors on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTRKLCW
a Schistocerca gregaria protease inhibitor-1 P4-P4' sequence mutant
alpha-2-Macroglobulin
-
-
-
alpha2-Macroglobulin
may be a physiological inhibitor, 1-3fold molar excess, forms a stable complex with the enzyme
-
antithrombin
the inhibitor is not specific for MASP-1 versus MASP-2
-
antithrombin III
-
inhibitory in the presence of heparin on activity of MASP-1
-
C1 inhibitor
-
C1-inhibitor
-
cyclic GICSRSLPPICIPD
-
-
EDTA
-
inhibits binding of MASP-1 to immobilized mannan-binding lectin and L-ficolin/P35, when substituted for Ca2+
GICSRSLPPICIPD
-
-
lectin pathway C1-inhibitor
the inhibitor is not specific for MASP-1 versus MASP-2
-
MCTRKLCW
a Schistocerca gregaria protease inhibitor-1 P4-P4' sequence mutant
MCTRKLCY
a Schistocerca gregaria protease inhibitor-1 P4-P4' sequence mutant
pefabloc
-
i.e. 4-(2-aminoethyl)-benzenesulphonyl fluoride
plasmaprotease C1-inhibitor
-
-
Schistocerca gregaria protease inhibitor-1
-
Schistocerca gregaria protease inhibitor-2 variant FCTRKLCY
randomization of positions P4, P2, P1, P1', P2', and P4' of the protease binding loop while keeping the structurally indispensable Cys at P3 and P3' leads to monospecific MASP inhibitors. Inhibitor variant FCTRKLCY is specific for isoform MASP-1, treatment completely blocks the lectin pathway activation, demonstrating that MASP-1 is not an auxiliary but an essential pathway component
-
SGMI-1
selective MASP-1 inhibitor, based on the Schistocerca gregaria protease inhibitor scaffold
-
sunflower MASP inhibitor-1
SFMI-1, sequence P4-P4' is ICSRSLPP
VCTRLWCE
a sunflower MASP inhibitor-2 P4-P4' sequence mutant, only slight inhibition
VCTRLWCN
a sunflower MASP inhibitor-2 P4-P4' sequence mutant, only slight inhibition
VCTRLYCN
a sunflower MASP inhibitor-2 P4-P4' sequence mutant, only slight inhibition
additional information
-