3.4.21.B7: mannan-binding lectin-associated serine protease 1

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For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.

Reaction

endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =

Synonyms

mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B7 mannan-binding lectin-associated serine protease 1

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Results	in table
4	Activating Compound
3	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
6	Crystallization (Commentary)
199	Disease/ Diagnostics
3	Expression
31	General Information
1	General Stability
32	Inhibitors
8	kcat/KM [mM/s]
12	Ki Value [mM]
9	KM Value [mM]
3	Localization
6	Metals/Ions
27	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
59	Organism
3	pH Optimum
1	pH Range
1	pI Value
5	Posttranslational Modification
9	Protein Variants
16	Purification (Commentary)
1	Reaction
24	Reaction Type
59	Reference
1	Renatured (Commentary)
35	Source Tissue
129	Substrates and Products (Substrate)
15	Subunits
69	Synonyms
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
6	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000027

ACTRKLCW

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057

0.000275

cyclic GICSRSLPPICIPD

Homo sapiens

-

in 20 mM HEPES, 145 mM NaCl, 5 mM CaCl2, and 0.05% (v/v) Triton X-100, at pH 7.6 and 22°C

717934

0.000065

GICSRSLPPICIPD

Homo sapiens

-

in 20 mM HEPES, 145 mM NaCl, 5 mM CaCl2, and 0.05% (v/v) Triton X-100, at pH 7.6 and 22°C

717934

0.00002

MCTRKLCW

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057

0.000014

MCTRKLCY

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057

0.000007

Schistocerca gregaria protease inhibitor-1

2 entries

-

0.000007

Schistocerca gregaria protease inhibitor-2 variant FCTRKLCY

Homo sapiens

P48740

pH not specified in the publication, temperature not specified in the publication

732057

-

0.000065

sunflower MASP inhibitor-1

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057

0.153

VCTRLWCE

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057

0.087

VCTRLWCN

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057

0.176

VCTRLYCN

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057

0.000007

Schistocerca gregaria protease inhibitor-1

Homo sapiens

P48740

pH and temperature not specified in the publication, recombinant enzyme

732057, 732520

-

0.000007

Schistocerca gregaria protease inhibitor-1

Homo sapiens

-

pH and temperature not specified in the publication, recombinant enzyme

732520

-