Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-factor D + H2O | Homo sapiens | - |
factor D + ? | - |
? | |
pro-factor D + H2O | Mus musculus | - |
factor D + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P48740 | - |
- |
Mus musculus | P48740 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-factor D + H2O | - |
Homo sapiens | factor D + ? | - |
? | |
pro-factor D + H2O | - |
Mus musculus | factor D + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MASP-1 | - |
Homo sapiens |
MASP-1 | - |
Mus musculus |
MBL-associated serine protease-1 | - |
Homo sapiens |
MBL-associated serine protease-1 | - |
Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
at physiological ionic strength, alternative pathway activity is observed, high ionic strength buffer suppresses the weaker alternative pathway activity of the Masp1 knockout mouse to background levels | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | presence of a functional alternative pathway in a human patient with Malpuech-Michels-Mingarelli-Carnevale (3MC) syndrome caused by a genetic defect in the MASP1 gene, which abolishes the production of all three splice products of this gene: mannan-binding lectin-associated serine proteases 1 and 3, and MBL-associated protein of 44 kDa, a human complement | Homo sapiens |
metabolism | influence of buffer composition on the activity of the alternative pathway of complement activation in mice in the presence and the absence of the Masp1 gene products: MASP-1, MASP-3, and MAp44 | Mus musculus |
physiological function | the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function, overview | Mus musculus |
physiological function | the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function, overview. In humans, neither MASP-1 nor MASP-3 are required for alternative pathway function, overview | Homo sapiens |