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Literature summary for 3.4.21.B7 extracted from

  • Degn, S.; Jensenius, J.; Thiel, S.
    The pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function (2014), J. Immunol., 192, 5447-5448.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-factor D + H2O Homo sapiens
-
factor D + ?
-
?
pro-factor D + H2O Mus musculus
-
factor D + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P48740
-
-
Mus musculus P48740
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-factor D + H2O
-
Homo sapiens factor D + ?
-
?
pro-factor D + H2O
-
Mus musculus factor D + ?
-
?

Synonyms

Synonyms Comment Organism
MASP-1
-
Homo sapiens
MASP-1
-
Mus musculus
MBL-associated serine protease-1
-
Homo sapiens
MBL-associated serine protease-1
-
Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
at physiological ionic strength, alternative pathway activity is observed, high ionic strength buffer suppresses the weaker alternative pathway activity of the Masp1 knockout mouse to background levels Mus musculus

General Information

General Information Comment Organism
malfunction presence of a functional alternative pathway in a human patient with Malpuech-Michels-Mingarelli-Carnevale (3MC) syndrome caused by a genetic defect in the MASP1 gene, which abolishes the production of all three splice products of this gene: mannan-binding lectin-associated serine proteases 1 and 3, and MBL-associated protein of 44 kDa, a human complement Homo sapiens
metabolism influence of buffer composition on the activity of the alternative pathway of complement activation in mice in the presence and the absence of the Masp1 gene products: MASP-1, MASP-3, and MAp44 Mus musculus
physiological function the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function, overview Mus musculus
physiological function the pro-factor D cleaving activity of MASP-1/-3 is not required for alternative pathway function, overview. In humans, neither MASP-1 nor MASP-3 are required for alternative pathway function, overview Homo sapiens