3.4.21.B7: mannan-binding lectin-associated serine protease 1
This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.
Word Map on EC 3.4.21.B7
-
3.4.21.B7
-
masp-3
-
silk
-
spider
-
ficolins
-
dragline
-
c1s
-
ampullate
-
spidroins
-
convertase
-
collagen-like
-
clavipes
-
collectins
-
m-ficolin
-
autoactivation
-
nephila
-
subcomponents
-
complement-activating
-
c1-inhibitor
-
latrodectus
-
pattern-recognition
-
widow
-
fibrinogen-like
-
protease-2
-
opsonin
-
extensibility
-
urochord
-
c1-inh
-
hesperus
-
medicine
- 3.4.21.B7
- masp-3
-
silk
- spider
- ficolins
-
dragline
- c1s
-
ampullate
-
spidroins
-
convertase
-
collagen-like
- clavipes
-
collectins
- m-ficolin
-
autoactivation
- nephila
-
subcomponents
-
complement-activating
- c1-inhibitor
- latrodectus
-
pattern-recognition
- widow
-
fibrinogen-like
-
protease-2
-
opsonin
-
extensibility
-
urochord
-
c1-inh
- hesperus
- medicine
Reaction
endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =
Synonyms
mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198
ECTree
3.4.21.B7 mannan-binding lectin-associated serine protease 1Advanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
benzoyl-L-arginine p-nitroanilide + H2O
benzoyl-L-arginine + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
activates complement C3
-
?
complement-activating component of Ra-reactive factor + H2O
?
cleavage at Arg448-/-Ile449
-
-
?
D-Phe-Pip-Arg-4-nitroanilide + H2O
D-Phe-Pip-Arg + 4-nitroaniline
a chromogenic thrombin substrate, recombinant human mannose-binding lectin alone fails to cleave the substrate, but cleavage is restored when the recombinant enzyme MASP-1 is added to either MASP-1/-3 KO sera or rhMBL
-
-
?
factor XIII A-chain + H2O
?
catalytic activity for factor XIII and fibrinogen cleavage is much lower than that of thrombin
-
-
?
fibrinogen beta-chain + H2O
?
cleavage at R44-/-G45 and other sites
-
-
?
high-molecular weight kininogen + H2O
bradykinin + ?
a noncomplement substrate, activation
-
-
?
low-molecular-weight kininogen + H2O
?
-
the cleavage rate of low-molecular-weight kininogen by MASP-1 is about 5times lower than that of kininogen
-
-
?
MASP1 mannan-binding lectin serine protease 1 isoform 1 precursor + H2O
?
autodegradation pattern of the MASP-1 CCP1-CCP2-SP fragment. Cleavage occurs at the Arg504-Asp505 bond, which results in the removal of a 6000 Da fragment from the active enzyme. The autolysis of the MASP-1 CCP1-CCP2-SP fragment causes the loss of its enzymatic activity due to the removal of the histidine from the catalytic triad
-
-
?
N-carbobenzoxy-L-lysine-4-nitrophenyl ester + H2O
N-carbobenzoxy-L-Lys + 4-nitrophenol
-
-
-
?
proform mannan-binding lectin-associated serine protease 1 + H2O
mature mannan-binding lectin-associated serine protease 1 + ?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
proform mannan-binding lectin-associated serine protease 3 + H2O
mature mannan-binding lectin-associated serine protease 3 + ?
proform protease activated receptor 4 + H2O
mature protease activated receptor 4 + ?
activation
-
-
?
proform thrombin-activatable fibrinolysis inhibitor + H2O
mature thrombin-activatable fibrinolysis inhibitor + ?
complement component C2 + H2O
?
digested by the MASP-1 CCP1-CCP2-SP fragment at a moderate rate
-
-
?
complement component C3 + H2O
?
cleavage with appearance of the alpha-chain
-
-
?
complement component C3i + H2O
?
cleavage of intact C3i (C3 with a reacted thiolester bond) by the MASP-1 CCP1-CCP2-SP fragment with a low but significant efficiency
-
-
?
Fibrinogen + H2O
?
rMASP1 cleavage of fibrinogen leads to the release of the proinflammatory peptide fibrinopeptide B. Catalytic activity for factor XIII and fibrinogen cleavage is much lower than that of thrombin
-
-
?
fibrinogen + H2O
fibrin + ?
MASP-1-induced fibrin formation and activation is thrombin-dependent, in plasma environment fibrin formation is not directly induced by MASP-1 in the absence of prothrombin
-
-
?
MASP-2 zymogen + H2O
mature MASP-2 + ?
MASP-2 is a key enzyme that cleaves C4 and C2 to assemble a C3 convertase
-
-
?
proform coagulation factor XIII + H2O
mature coagulation factor XIII + ?
-
-
-
?
proform coagulation factor XIII + H2O
mature coagulation factor XIII + ?
a noncomplement substrate, activation
-
-
?
proform factor XIII + H2O
mature factor XIII + ?
the Val34 variant is a better substrate than the Leu34 variant
-
-
?
proform mannan-binding lectin-associated serine protease 1 + H2O
mature mannan-binding lectin-associated serine protease 1 + ?
autocatalytic cleavage, a complement substrate, activation
-
-
?
proform mannan-binding lectin-associated serine protease 1 + H2O
mature mannan-binding lectin-associated serine protease 1 + ?
-
autocatalytic cleavage, a complement substrate, activation
-
-
?
proform mannan-binding lectin-associated serine protease 1 + H2O
mature mannan-binding lectin-associated serine protease 1 + ?
autocatalytic cleavage
-
-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
-
-
-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
activation
-
-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
a complement substrate, activation
-
-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
-
a complement substrate, activation
-
-
?
proform mannan-binding lectin-associated serine protease 2 + H2O
mature mannan-binding lectin-associated serine protease 2 + ?
enzyme MASP-1 is the main activator of MASP-2
-
-
?
proform mannan-binding lectin-associated serine protease 3 + H2O
mature mannan-binding lectin-associated serine protease 3 + ?
-
-
-
?
proform mannan-binding lectin-associated serine protease 3 + H2O
mature mannan-binding lectin-associated serine protease 3 + ?
a complement substrate, activation
-
-
?
proform thrombin-activatable fibrinolysis inhibitor + H2O
mature thrombin-activatable fibrinolysis inhibitor + ?
-
-
-
?
proform thrombin-activatable fibrinolysis inhibitor + H2O
mature thrombin-activatable fibrinolysis inhibitor + ?
activation
-
-
?
protease activated receptor 4 + H2O
?
PAR4, a noncomplement substrate, activation
-
-
?
prothrombin + H2O
thrombin + ?
a noncomplement substrate, activation
-
-
?
prothrombin + H2O
thrombin a + ?
enzyme MASP-1 cleaves prothrombinat three cleavage sites, MASP-1 gives rise to an alternative active form of thrombin by cleaving at the cleavage site R393
-
-
?
prothrombin + H2O
thrombin a + ?
enzyme MASP-1 cleaves prothrombinant three cleavage sites
-
-
?
additional information
?
-
-
complexes with mannose-binding lectin in the presence of Ca2+, involved in activation of complement cascade
-
?
additional information
?
-
involved in activation of complement cascade
-
?
additional information
?
-
-
involved in activation of complement cascade
-
?
additional information
?
-
-
involved in activation of complement cascade, circulates in serum complexed with mannose-binding protein
-
?
additional information
?
-
-
involved in activation of complement cascade, forms a complex with mannose-binding lectin
-
?
additional information
?
-
-
involved in activation of complement cascade, smallest functional unit for complement activation consists of serum mannose-binding protein dimers bound to MASP-1 homodimers
-
?
additional information
?
-
-
no cleavage of complement C4 by purified MASP-1
-
-
?
additional information
?
-
-
MASP-1 shows no activity toward complement C4. MASP-1 collaborates with MASP-2 in the generation of C3 convertase, a process observable at high serum concentration, but not at low serum concentration
-
-
?
additional information
?
-
autoactivation by cleavage of R448-/-I449. The enzyme is relatively unspecific
-
-
?
additional information
?
-
complement component C4, similar to C3, is basically resistant to the proteolytic activity of MASP-1. MASP-1 shows extreme Arg selectivity
-
-
?
additional information
?
-
-
MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII
-
-
?
additional information
?
-
-
MASP-1 cannot cleave complement component C4, recombinant MASP-1 does not activate plasma prekallikrein
-
-
?
additional information
?
-
no activity with complement component C4. Direct activation of C3 convertase by MASP-1 occurs with very low catalytic efficiency and is not of physiological relevance
-
-
?
additional information
?
-
the enzyme MASP-1 shows a more relaxed substrate specificity. MASP-1 zymogen is fairly active on small substrates, and itautoactivates rapidly due to its relatively fast zymogen autoacti-vation step
-
-
?
additional information
?
-
-
the enzyme MASP-1 shows a more relaxed substrate specificity. MASP-1 zymogen is fairly active on small substrates, and itautoactivates rapidly due to its relatively fast zymogen autoacti-vation step
-
-
?
additional information
?
-
-
involved in activation of complement cascade
-
?
additional information
?
-
-
involved in activation of complement cascade
-
?
additional information
?
-
involved in activation of complement cascade, enzyme is complexed with the mannose-binding protein
-
?
additional information
?
-
-
involved in activation of complement cascade, enzyme is complexed with the mannose-binding protein
-
?
additional information
?
-
-
involved in activation of complement cascade, forms a complex with mannose-binding lectin
-
?
additional information
?
-
MASP-1 contributes to the activation of the lectin pathway, probably through the activation of MASP-2
-
-
?
additional information
?
-
-
MASP-1 contributes to the activation of the lectin pathway, probably through the activation of MASP-2
-
-
?
additional information
?
-
involved in activation of complement cascade, enzyme is complexed with the mannose-binding protein
-
?
additional information
?
-
-
involved in activation of complement cascade, circulates as a complex with mannose-binding protein, minimal functional unit for complement activation is a MASP homodimer bound to two mannose-binding protein trimeric subunits
-
?
additional information
?
-
-
no cleavage of complement C4 and N-alpha-carbobenzoxy-L-lysine p-nitropenhyl ester
-
-
?
