3.4.21.B7: mannan-binding lectin-associated serine protease 1

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.

Word Map on EC 3.4.21.B7

3.4.21.B7

masp-3

silk

spider

ficolins

dragline

c1s

ampullate

spidroins

convertase

collagen-like

clavipes

collectins

m-ficolin

autoactivation

nephila

subcomponents

complement-activating

c1-inhibitor

latrodectus

pattern-recognition

widow

fibrinogen-like

protease-2

opsonin

extensibility

urochord

c1-inh

hesperus

medicine

Reaction

endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =

Synonyms

mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B7 mannan-binding lectin-associated serine protease 1

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Results	in table
4	Activating Compound
3	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
6	Crystallization (Commentary)
199	Disease/ Diagnostics
3	Expression
31	General Information
1	General Stability
32	Inhibitors
8	kcat/KM [mM/s]
12	Ki Value [mM]
9	KM Value [mM]
3	Localization
6	Metals/Ions
27	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
59	Organism
3	pH Optimum
1	pH Range
1	pI Value
5	Posttranslational Modification
9	Protein Variants
16	Purification (Commentary)
1	Reaction
24	Reaction Type
59	Reference
1	Renatured (Commentary)
35	Source Tissue
129	Substrates and Products (Substrate)
15	Subunits
69	Synonyms
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
6	Turnover Number [1/s]

Purification

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Purification on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1

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4 entries

by affinity chromatography

2 entries

mannan-agarose column chromatography

Homo sapiens

708697

MBL-derivatized Sepharose column chromatography

partial

recombinant wild-type and mutant MASP-1 catalytic fragments encoding the complement control protein domains 1 and 2, CCP1-CCP2-SP, region from Escherichia coli by repeated anion exchange chromatography and gel filtration

Homo sapiens

P48740

732519

refolded recombinant chitin-binding domain-tagged MAPS-1 CUB1-EGF-CUB2 by anion echange chromatography and gel filtration

Homo sapiens

P48740

732518