3.4.21.B7: mannan-binding lectin-associated serine protease 1
This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.
Word Map on EC 3.4.21.B7
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3.4.21.B7
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masp-3
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silk
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spider
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ficolins
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dragline
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c1s
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ampullate
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spidroins
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convertase
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collagen-like
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clavipes
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collectins
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m-ficolin
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autoactivation
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nephila
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subcomponents
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complement-activating
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c1-inhibitor
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latrodectus
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pattern-recognition
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widow
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fibrinogen-like
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protease-2
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opsonin
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extensibility
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urochord
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c1-inh
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hesperus
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medicine
- 3.4.21.B7
- masp-3
-
silk
- spider
- ficolins
-
dragline
- c1s
-
ampullate
-
spidroins
-
convertase
-
collagen-like
- clavipes
-
collectins
- m-ficolin
-
autoactivation
- nephila
-
subcomponents
-
complement-activating
- c1-inhibitor
- latrodectus
-
pattern-recognition
- widow
-
fibrinogen-like
-
protease-2
-
opsonin
-
extensibility
-
urochord
-
c1-inh
- hesperus
- medicine
Reaction
endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =
Synonyms
mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198
ECTree
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Temperature Stability
Temperature Stability on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1
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37
mutant R504Q catalytic fragment, the mutant is resistant to autolysis and preserves its enzymatic activity during prolonged incubation, estimated half-life of several hours in plasma at 37°C
37
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95% loss of C4-cleaving activity after 30 min in 130 mM NaCl, 2 mM CaCl2, 20 mM Tris, pH8